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Victor Darley-Usmar

Victor Darley-Usmar (born in Worksop, Nottinghamshire, England in 1956) is a free-radical biologist and biochemist, the UAB Endowed Professor in Mitochondrial Medicine and Pathology at the University of Alabama at Birmingham.[1] Darley-Usmar also contributed to a book titled Microbes, Bugs & Wonder Drugs (by Fran Balkwill and Mic Rolph, with Victor Darley-Usmar), a science book written for young readers and their families.[2][3]

Scientific background edit

Dr. Darley-Usmar got his B.Sc. from Essex University in Biochemistry in 1976, and followed that by getting a PhD from Essex University in 1980. He then did a postdoctoral fellowship at the University of Oregon from 1980-1983. Darley-Usmar then accepted a position as an assistant professor at the University of Tsukuba Medical School in Ibaraki, Japan, where he taught for 2 years. He then moved to Beckenham, Kent, England to be a Senior Biochemist at Wellcome Research Laboratories, where he stayed for 10 years. In 1995, he was recruited to University of Alabama at Birmingham, where he is now a professor.[4]

Darley-Usmar has held several leadership positions during his time at UAB. He has been the Graduate Program Director for the Department of Pathology, the Associate Dean for the Office of Post-Doctoral Education, the Chair of the Conflict of Interest Review Board, and has been the Interim Director for the Division of Molecular and Cellular Pathology twice. He is currently the Director of the Centre for Free Radical Biology and the Vice-Chair of Research for the Department of Pathology.

Darley-Usmar is also past President of the Society for Free Radical Biology and Medicine,[4] and is one of the two editors-in-chief of the journal Redox Biology.[1]

Awards edit

  • 2012 Lifetime Achievement Award, Society for Free Radical Biology and Medicine.[5]
  • 2009: Deans Award for Excellence in Mentoring
  • 2006: Award from the UAB Post Doctoral Association for Outstanding Contribution to Post Doctoral Education
  • 1998, 2003, 2005: Most Valued Faculty Member: Awarded by graduate students in the Molecular and Cellular Pathology Program.
  • 2001: Outstanding volunteer for the Oxygen Society.
  • 1996: Highly Commended Award for the British Medical Association Medical Book Competition for Microbes Bugs and Wonder Drugs.

Research interests edit

Among the most serious diseases that effect developed nations are those involving the cardiovascular system. Typical examples include atherosclerosis and the vascular complications of hypertension and diabetes. It is now known that this is mainly due to the production of free radicals and their interactions in the cells of the artery wall. The focus of Darley-Usmar's laboratory is to understand how the signaling pathways are altered in vascular disease and how free radicals play a part in this.

Two areas are of particular interest to Darley-Usmar. 1) Those involving oxidized lipoproteins and 2) the free radical signaling molecule nitric oxide. Nitric oxide is one of the beneficial free radicals in the artery wall and in a series of studies over the last few years he has been determining how it exerts protection over the vasculature.[6] Dr. Darley-Usmar is particularly interested in how the interaction of mitochondria with NO can modulate cell signaling. With an extensive network of collaborators at UAB and at other national and international institutions, he is defining the molecular events which control NO signaling pathways in the diseased vessel wall. Darley-Usmar's approach is to use his insight into the biochemistry of free radicals to understand events at the cellular level. Recently, he has found that NO activates a previously uncharacterized signaling pathway in the mitochondrion that increases synthesis of intracellular antioxidants in the cell in addition to directly inactivating damaging free radicals. His lab uses molecular biology, proteomics, and cellular approaches to address these problems.

Selected publications edit

  • Sruti Shiva, Paul S. Brookes, Rakesh P. Patel, Peter G. Anderson, and Victor M. Darley-Usmar. Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. PNAS 2001. [1].
  • Paul S. Brookes, David W. Kraus, Sruti Shiva, Jeannette E. Doeller, Maria-Cecilia Barone, Rakesh P. Patel, Jack R. Lancaster, Jr., and Victor Darley-Usmar. Control of Mitochondrial Respiration by NO, Effects of Low Oxygen and Respiratory State. JBC 2003. [2]

References edit

  1. ^ a b V.M. Darley-Usmar, Editors-in-Chief, Redox Biology, Elsevier, retrieved 2013-05-19.
  2. ^ "Review : Bugs and bangs . . .", New Scientist, 11 May 1996.
  3. ^ Review of Microbes, Bugs & Wonder Drugs by J K Candlish (1995), Biochemical Education 23 (4): 221–222, doi:10.1016/0307-4412(95)90172-8.
  4. ^ a b "President's interview" (PDF), SFRBMdot, 1 (1), Fall 2008.
  5. ^ Awards for Senior Investigators, SFRBM, retrieved 2013-05-19.
  6. ^ Shiva et al. 2001; Brookes et al. 2003.

External links edit

  • University of Alabama at Birmingham
  • Center for Free Radical Biology
  • Society for Free Radical Biology and Medicine
  • Seahorse Bioscience

victor, darley, usmar, born, worksop, nottinghamshire, england, 1956, free, radical, biologist, biochemist, endowed, professor, mitochondrial, medicine, pathology, university, alabama, birmingham, darley, usmar, also, contributed, book, titled, microbes, bugs,. Victor Darley Usmar born in Worksop Nottinghamshire England in 1956 is a free radical biologist and biochemist the UAB Endowed Professor in Mitochondrial Medicine and Pathology at the University of Alabama at Birmingham 1 Darley Usmar also contributed to a book titled Microbes Bugs amp Wonder Drugs by Fran Balkwill and Mic Rolph with Victor Darley Usmar a science book written for young readers and their families 2 3 Contents 1 Scientific background 2 Awards 3 Research interests 4 Selected publications 5 References 6 External linksScientific background editDr Darley Usmar got his B Sc from Essex University in Biochemistry in 1976 and followed that by getting a PhD from Essex University in 1980 He then did a postdoctoral fellowship at the University of Oregon from 1980 1983 Darley Usmar then accepted a position as an assistant professor at the University of Tsukuba Medical School in Ibaraki Japan where he taught for 2 years He then moved to Beckenham Kent England to be a Senior Biochemist at Wellcome Research Laboratories where he stayed for 10 years In 1995 he was recruited to University of Alabama at Birmingham where he is now a professor 4 Darley Usmar has held several leadership positions during his time at UAB He has been the Graduate Program Director for the Department of Pathology the Associate Dean for the Office of Post Doctoral Education the Chair of the Conflict of Interest Review Board and has been the Interim Director for the Division of Molecular and Cellular Pathology twice He is currently the Director of the Centre for Free Radical Biology and the Vice Chair of Research for the Department of Pathology Darley Usmar is also past President of the Society for Free Radical Biology and Medicine 4 and is one of the two editors in chief of the journal Redox Biology 1 Awards edit2012 Lifetime Achievement Award Society for Free Radical Biology and Medicine 5 2009 Deans Award for Excellence in Mentoring 2006 Award from the UAB Post Doctoral Association for Outstanding Contribution to Post Doctoral Education 1998 2003 2005 Most Valued Faculty Member Awarded by graduate students in the Molecular and Cellular Pathology Program 2001 Outstanding volunteer for the Oxygen Society 1996 Highly Commended Award for the British Medical Association Medical Book Competition for Microbes Bugs and Wonder Drugs Research interests editAmong the most serious diseases that effect developed nations are those involving the cardiovascular system Typical examples include atherosclerosis and the vascular complications of hypertension and diabetes It is now known that this is mainly due to the production of free radicals and their interactions in the cells of the artery wall The focus of Darley Usmar s laboratory is to understand how the signaling pathways are altered in vascular disease and how free radicals play a part in this Two areas are of particular interest to Darley Usmar 1 Those involving oxidized lipoproteins and 2 the free radical signaling molecule nitric oxide Nitric oxide is one of the beneficial free radicals in the artery wall and in a series of studies over the last few years he has been determining how it exerts protection over the vasculature 6 Dr Darley Usmar is particularly interested in how the interaction of mitochondria with NO can modulate cell signaling With an extensive network of collaborators at UAB and at other national and international institutions he is defining the molecular events which control NO signaling pathways in the diseased vessel wall Darley Usmar s approach is to use his insight into the biochemistry of free radicals to understand events at the cellular level Recently he has found that NO activates a previously uncharacterized signaling pathway in the mitochondrion that increases synthesis of intracellular antioxidants in the cell in addition to directly inactivating damaging free radicals His lab uses molecular biology proteomics and cellular approaches to address these problems Selected publications editSruti Shiva Paul S Brookes Rakesh P Patel Peter G Anderson and Victor M Darley Usmar Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase PNAS 2001 1 Paul S Brookes David W Kraus Sruti Shiva Jeannette E Doeller Maria Cecilia Barone Rakesh P Patel Jack R Lancaster Jr and Victor Darley Usmar Control of Mitochondrial Respiration by NO Effects of Low Oxygen and Respiratory State JBC 2003 2 References edit a b V M Darley Usmar Editors in Chief Redox Biology Elsevier retrieved 2013 05 19 Review Bugs and bangs New Scientist 11 May 1996 Review of Microbes Bugs amp Wonder Drugs by J K Candlish 1995 Biochemical Education 23 4 221 222 doi 10 1016 0307 4412 95 90172 8 a b President s interview PDF SFRBMdot 1 1 Fall 2008 Awards for Senior Investigators SFRBM retrieved 2013 05 19 Shiva et al 2001 Brookes et al 2003 External links editUniversity of Alabama at Birmingham Center for Free Radical Biology Society for Free Radical Biology and Medicine Seahorse Bioscience Retrieved from https en wikipedia org w index php title Victor Darley Usmar amp oldid 1084407899, wikipedia, wiki, book, books, library,

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