Van Wyk and Grumbach syndrome is a medical condition defined by a combination of hypothyroidism, precocious puberty (usually with delayed bone age) and ovarian cysts in pre- and post-pubertal girls.
The presumed pathogenesis is that primary hypothyroidism causes enlargement and hyperstimulation of the pituitary gland which in turn cause ovarian hyperstimulation, ovarian cysts and precocious puberty.[citation needed]
Diagnosis
Diagnosis is made by imaging/sonography and thyroid hormone tests.[citation needed]
Treatment
The syndrome usually responds well to thyroid hormone replacement with complete resolution of symptoms.[citation needed]
^Browne, L. P.; Boswell, H. B.; Crotty, E. J.; O'Hara, S. M.; Birkemeier, K. L.; Guillerman, R. P. (2008). "Van Wyk and Grumbach syndrome revisited: Imaging and clinical findings in pre- and postpubertal girls". Pediatric Radiology. 38 (5): 538–42. doi:10.1007/s00247-008-0777-1. PMID 18283448. S2CID 10001906.
^Patni, N; Cervantes, L. F.; Diaz, A (2012). "Elevated alpha-fetoprotein levels in Van Wyk-Grumbach syndrome: A case report and review of literature". Journal of Pediatric Endocrinology & Metabolism. 25 (7–8): 761–7. doi:10.1515/jpem-2012-0112. PMID 23155707. S2CID 70369330.
^Hunold, A; Alzen, G; Wudy, S. A.; Bluetters-Sawatzki, R; Landmann, E; Reiter, A; Wagner, H. J. (2009). "Ovarian tumor in a 12-year old female with severe hypothyroidism: A case of Van Wyk and Grumbach syndrome". Pediatric Blood & Cancer. 52 (5): 677–9. doi:10.1002/pbc.21920. PMID 19127572. S2CID 21495694.
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grumbach, syndrome, medical, condition, defined, combination, hypothyroidism, precocious, puberty, usually, with, delayed, bone, ovarian, cysts, post, pubertal, girls, specialtyendocrine, contents, presentation, mechanism, diagnosis, treatment, history, refere. Van Wyk and Grumbach syndrome is a medical condition defined by a combination of hypothyroidism precocious puberty usually with delayed bone age and ovarian cysts in pre and post pubertal girls Van Wyk and Grumbach syndromeSpecialtyEndocrine Contents 1 Presentation 2 Mechanism 3 Diagnosis 4 Treatment 5 History 6 ReferencesPresentation EditSymptoms are ascites pleural and pericardial effusions elevated ovarian tumour markers enlarged pituitary gland and elevated prolactin and alpha fetoprotein levels citation needed Mechanism EditThe presumed pathogenesis is that primary hypothyroidism causes enlargement and hyperstimulation of the pituitary gland which in turn cause ovarian hyperstimulation ovarian cysts and precocious puberty citation needed Diagnosis EditDiagnosis is made by imaging sonography and thyroid hormone tests citation needed Treatment EditThe syndrome usually responds well to thyroid hormone replacement with complete resolution of symptoms citation needed History EditThe syndrome was described in 1960 by Van Wyk and Melvin M Grumbach 1 2 3 References Edit Browne L P Boswell H B Crotty E J O Hara S M Birkemeier K L Guillerman R P 2008 Van Wyk and Grumbach syndrome revisited Imaging and clinical findings in pre and postpubertal girls Pediatric Radiology 38 5 538 42 doi 10 1007 s00247 008 0777 1 PMID 18283448 S2CID 10001906 Patni N Cervantes L F Diaz A 2012 Elevated alpha fetoprotein levels in Van Wyk Grumbach syndrome A case report and review of literature Journal of Pediatric Endocrinology amp Metabolism 25 7 8 761 7 doi 10 1515 jpem 2012 0112 PMID 23155707 S2CID 70369330 Hunold A Alzen G Wudy S A Bluetters Sawatzki R Landmann E Reiter A Wagner H J 2009 Ovarian tumor in a 12 year old female with severe hypothyroidism A case of Van Wyk and Grumbach syndrome Pediatric Blood amp Cancer 52 5 677 9 doi 10 1002 pbc 21920 PMID 19127572 S2CID 21495694 This article about an endocrine nutritional or metabolic disease is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Van Wyk and Grumbach syndrome amp oldid 1099309596, wikipedia, wiki, book, books, library,
