Genetic transformation is the process by which a recipient bacterial cell takes up naked DNA from its environment and integrates this DNA into the recipient's genome by recombination. In N. meningitidis, DNA transformation requires the presence of short DUS (10-12 mers residing in coding and intergenic regions) of the donor DNA. Specific recognition of DUSs is mediated by a type IV pilin.[2] Davidsen et al.[3] reported that in N. meningitidis DUSs occur at a significantly higher density in genes involved in DNA repair and recombination (as well as in restriction-modification and replication) than in other annotated gene groups. These authors proposed that the over-representation of DUS in DNA repair and recombination genes may reflect the benefit of maintaining the integrity of the DNA repair and recombination machinery by preferentially taking up genome maintenance genes that could replace their damaged counterparts in the recipient cell's genome. Uptake of such genes could provide a mechanism for facilitating recovery from DNA damage after genotoxic stress.
References
^Frye SA, Nilsen M, Tønjum T, Ambur OH (2013). "Dialects of the DNA uptake sequence in Neisseriaceae". PLOS Genet. 9 (4): 3065–70. doi:10.1371/journal.pgen.1003458. PMC3630211. PMID 23637627.
^Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic V (2013). "Specific DNA recognition mediated by a type IV pilin". Proc. Natl. Acad. Sci. U.S.A. 110 (8): 3065–70. Bibcode:2013PNAS..110.3065C. doi:10.1073/pnas.1218832110. PMC3581936. PMID 23386723.
^Davidsen T, Rødland EA, Lagesen K, Seeberg E, Rognes T, Tønjum T (2004). "Biased distribution of DNA uptake sequences towards genome maintenance genes". Nucleic Acids Res. 32 (3): 1050–8. doi:10.1093/nar/gkh255. PMC373393. PMID 14960717.
External links
Bakkali, M.; Chen, T.-Y.; Lee, H. C.; Redfield, R. J. (2004). "Evolutionary stability of DNA uptake signal sequences in the Pasteurellaceae". Proceedings of the National Academy of Sciences. 101 (13): 4513–4518. Bibcode:2004PNAS..101.4513B. doi:10.1073/pnas.0306366101. PMC384778. PMID 15070749.
Bakkali, Mohammed (2007). Fairhead, Cecile (ed.). "Genome Dynamics of Short Oligonucleotides: The Example of Bacterial DNA Uptake Enhancing Sequences". PLoS ONE. 2 (8): e741. Bibcode:2007PLoSO...2..741B. doi:10.1371/journal.pone.0000741. PMC1939737. PMID 17710141.
This genetics article is a stub. You can help Wikipedia by expanding it.
uptake, signal, sequence, short, sequences, preferentially, taken, competent, bacteria, family, pasteurellaceae, haemophilus, influenzae, similar, sequences, called, uptake, sequences, found, species, family, neisseriaceae, including, neisseria, meningitidis, . Uptake signal sequences USS are short DNA sequences preferentially taken up by competent bacteria of the family Pasteurellaceae e g Haemophilus influenzae Similar sequences called DNA uptake sequences DUS are found in species of the family Neisseriaceae including Neisseria meningitidis and Neisseria gonorrhoeae 1 Neisseria meningitidis EditGenetic transformation is the process by which a recipient bacterial cell takes up naked DNA from its environment and integrates this DNA into the recipient s genome by recombination In N meningitidis DNA transformation requires the presence of short DUS 10 12 mers residing in coding and intergenic regions of the donor DNA Specific recognition of DUSs is mediated by a type IV pilin 2 Davidsen et al 3 reported that in N meningitidis DUSs occur at a significantly higher density in genes involved in DNA repair and recombination as well as in restriction modification and replication than in other annotated gene groups These authors proposed that the over representation of DUS in DNA repair and recombination genes may reflect the benefit of maintaining the integrity of the DNA repair and recombination machinery by preferentially taking up genome maintenance genes that could replace their damaged counterparts in the recipient cell s genome Uptake of such genes could provide a mechanism for facilitating recovery from DNA damage after genotoxic stress References Edit Frye SA Nilsen M Tonjum T Ambur OH 2013 Dialects of the DNA uptake sequence in Neisseriaceae PLOS Genet 9 4 3065 70 doi 10 1371 journal pgen 1003458 PMC 3630211 PMID 23637627 Cehovin A Simpson PJ McDowell MA Brown DR Noschese R Pallett M Brady J Baldwin GS Lea SM Matthews SJ Pelicic V 2013 Specific DNA recognition mediated by a type IV pilin Proc Natl Acad Sci U S A 110 8 3065 70 Bibcode 2013PNAS 110 3065C doi 10 1073 pnas 1218832110 PMC 3581936 PMID 23386723 Davidsen T Rodland EA Lagesen K Seeberg E Rognes T Tonjum T 2004 Biased distribution of DNA uptake sequences towards genome maintenance genes Nucleic Acids Res 32 3 1050 8 doi 10 1093 nar gkh255 PMC 373393 PMID 14960717 External links EditBakkali M Chen T Y Lee H C Redfield R J 2004 Evolutionary stability of DNA uptake signal sequences in the Pasteurellaceae Proceedings of the National Academy of Sciences 101 13 4513 4518 Bibcode 2004PNAS 101 4513B doi 10 1073 pnas 0306366101 PMC 384778 PMID 15070749 Bakkali Mohammed 2007 Fairhead Cecile ed Genome Dynamics of Short Oligonucleotides The Example of Bacterial DNA Uptake Enhancing Sequences PLoS ONE 2 8 e741 Bibcode 2007PLoSO 2 741B doi 10 1371 journal pone 0000741 PMC 1939737 PMID 17710141 This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Uptake signal sequence amp oldid 1086286834, wikipedia, wiki, book, books, library,
