Type V collagen is a part of the family of collagen proteins consisting of Collagen I- Collagen XXVIII. Collagen proteins are often associated with the strengthening and support of many tissues including skin, bones, muscles, and ligaments. There are some studies that suggest that Type V collagen is responsible for the formation of other collagen fibrils in different tissues within the body.[3] According to studies, Collagen V regulates the heterotypic fiber diameter.[4] Type V Collagen is considered a regulatory fibril forming collagen.[5] Collagen V is associated with the COL5A1 gene which is the gene which provides instructions to produce Collagen V. Type V Collagen, like other collagens, is made up of procollagen molecules.
Collagen V molecular isoforms are α1(V)α2(V)α3(V), α1(V)3, and α1(V)2 α2(V). These procollagen molecules are made up of three different α -polypeptide chains.[5] These α -polypeptide chains are α1(V), α2(V), and α3(V). Different combinations of these chains form the Type V collagen Isoforms. Procollagen molecules then form mature collagen with the help of enzymes. After the chains are formed, they arrange into thin fibrils. These collagen fibrils then assort with type I collagen fibrils.[3]
Type V collagen is a part of the Extracellular Matrix (ECM).[5] Collagen V is gene expression modulated by TGF-β. Type V collagen has shown that it is resistant to digestion by interstitial collagenases. Denatured collagen V on the other hand, can be degraded by gelatinases as well as metalloproteinases.[5]
Type V collagen has a few alternative names alpha 1 These include: type V collagen preproprotein, CO5A1_HUMAN, and collagen type V alpha.[3] Type V collagen can also be abbreviated to COLV or collagen V.
Diseases associated with type V collagenedit
Some studies show that a mutation in the gene that codes for Type V collagen is linked as the cause of a form of Ehlers Danlos Syndrome. Ehlers Danlos Syndrome Classical Type is the result of mutations of the COL5A1 gene which codes Type V Collagen. This form of the Ehlers Danlos- Syndrome (classical type) is associated with hypermobility, scarring and elasticity of the skin and other tissues. Researchers discovered the cause of this form of Ehlers Danlos is due to the mutation that produces less chains from the three chains that make up Type V Collagen. Over 100 mutations to the gene COL5A1 have been identified. These mutations result in the underproduction of pro-α1(V) chains. With these mutations, Type V Collagen fibrils are not fully developed and disorganized. This results in the different symptoms of Ehlers Danlos Syndrome.[3]
Healthedit
Type V Collagen studies show that Collagen V plays some other roles in different parts of the body. These roles can be both beneficial and harmful.
Beneficial roles that Type V collagen plays in the body are:
Neoepitopes of Type V collagen have shown to be a useful noninvasive serum biomarker for assessing fibrotic progression and resolution in experimental hepatic fibrosis.[5]
Type V Collagens isoform which contains the α3(V) chain is involved in mediating pancreatic islet cell functions.[5]
Type V Collagens will arrange with Type I Collagen and form heterotypic fibrils in the skin dermis and cornea. Together, Collagen V and Collagen I acts as a dominant regulator of collagen fibrillogenesis.[5]
Type V Collagens interacts with matrix collagens and structural proteins. This interaction improves structural integrity to tissue scaffolds.[5]
Harmful roles that Type V collagen can play in the body.
Having a Type V Collagen deficiency has been associated with loss of corneal transparency and classic Ehlers-Danlos syndrome.[5]
Studies have shown that an overexpression of Type V Collagen can lead to harmful responses in the body. Collagen V overexpression has been found in cancer, granulation tissue, inflammation and atherosclerosis. It is also linked to fibrosis of the lungs, skin, kidneys, adipose tissue, and liver.[5]
Increases in Type V Collagen are associated with both early and advanced hepatic fibrosis.[5]
Studies show that increased synthesis of abnormal Type V Collagen is linked to the pathogenesis of Systemic Sclerosis[4]
Autoimmunity against type V collagen is associated with lung transplant failure.[6][7][8]
^Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE (December 2004). "Type V collagen controls the initiation of collagen fibril assembly". The Journal of Biological Chemistry. 279 (51): 53331–53337. doi:10.1074/jbc.M409622200. PMID 15383546.
^Malfait F, Wenstrup R, De Paepe A (1993). Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.). "Ehlers-Danlos Syndrome, Classic Type". GeneReviews. Seattle (WA): University of Washington, Seattle. PMID 20301422.
^ abMartin, Patricia; Teodoro, Walcy R.; Velosa, Ana Paula P.; de Morais, Jymenez; Carrasco, Solange; Christmann, Romy B.; Goldenstein-Schainberg, Cláudia; Parra, Edwin R.; Katayama, Maria Lúcia; Sotto, Mirian N.; Capelozzi, Vera L.; Yoshinari, Natalino H. (September 2012). "Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis". Autoimmunity Reviews. 11 (11): 827–835. doi:10.1016/j.autrev.2012.02.017. ISSN 1873-0183. PMID 22406224.
^ abcdefghijkMak, Ki M.; Png, Chien Yi M.; Lee, Danielle J. (May 2016). "Type V Collagen in Health, Disease, and Fibrosis". Anatomical Record (Hoboken, N.J.: 2007). 299 (5): 613–629. doi:10.1002/ar.23330. ISSN 1932-8494. PMID 26910848.
^"Studies on Collagen". www.collagencomplete.com. Retrieved 2016-07-13.
^Haque MA, Mizobuchi T, Yasufuku K, Fujisawa T, Brutkiewicz RR, Zheng Y, et al. (August 2002). "Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection". Journal of Immunology. 169 (3): 1542–1549. doi:10.4049/jimmunol.169.3.1542. PMID 12133982.
^Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, et al. (October 2008). "Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction". Journal of Immunology. 181 (8): 5738–5747. doi:10.4049/jimmunol.181.8.5738. PMC2997998. PMID 18832733.
type, collagen, form, fibrillar, collagen, associated, with, classical, ehlers, danlos, syndrome, found, within, dermal, epidermal, junction, placental, tissues, well, association, with, tissues, containing, type, collagen, part, family, collagen, proteins, co. Type V collagen is a form of fibrillar 1 collagen associated with classical Ehlers Danlos syndrome It is found within the dermal epidermal junction placental tissues as well as in association with tissues containing type I collagen 2 Type V collagen is a part of the family of collagen proteins consisting of Collagen I Collagen XXVIII Collagen proteins are often associated with the strengthening and support of many tissues including skin bones muscles and ligaments There are some studies that suggest that Type V collagen is responsible for the formation of other collagen fibrils in different tissues within the body 3 According to studies Collagen V regulates the heterotypic fiber diameter 4 Type V Collagen is considered a regulatory fibril forming collagen 5 Collagen V is associated with the COL5A1 gene which is the gene which provides instructions to produce Collagen V Type V Collagen like other collagens is made up of procollagen molecules Collagen V molecular isoforms are a1 V a2 V a3 V a1 V 3 and a1 V 2 a2 V These procollagen molecules are made up of three different a polypeptide chains 5 These a polypeptide chains are a1 V a2 V and a3 V Different combinations of these chains form the Type V collagen Isoforms Procollagen molecules then form mature collagen with the help of enzymes After the chains are formed they arrange into thin fibrils These collagen fibrils then assort with type I collagen fibrils 3 Type V collagen is a part of the Extracellular Matrix ECM 5 Collagen V is gene expression modulated by TGF b Type V collagen has shown that it is resistant to digestion by interstitial collagenases Denatured collagen V on the other hand can be degraded by gelatinases as well as metalloproteinases 5 Contents 1 Alternative names 2 Diseases associated with type V collagen 3 Health 4 Genes 5 References 6 External linksAlternative names editType V collagen has a few alternative names alpha 1 These include type V collagen preproprotein CO5A1 HUMAN and collagen type V alpha 3 Type V collagen can also be abbreviated to COLV or collagen V Diseases associated with type V collagen editSome studies show that a mutation in the gene that codes for Type V collagen is linked as the cause of a form of Ehlers Danlos Syndrome Ehlers Danlos Syndrome Classical Type is the result of mutations of the COL5A1 gene which codes Type V Collagen This form of the Ehlers Danlos Syndrome classical type is associated with hypermobility scarring and elasticity of the skin and other tissues Researchers discovered the cause of this form of Ehlers Danlos is due to the mutation that produces less chains from the three chains that make up Type V Collagen Over 100 mutations to the gene COL5A1 have been identified These mutations result in the underproduction of pro a1 V chains With these mutations Type V Collagen fibrils are not fully developed and disorganized This results in the different symptoms of Ehlers Danlos Syndrome 3 Health editType V Collagen studies show that Collagen V plays some other roles in different parts of the body These roles can be both beneficial and harmful Beneficial roles that Type V collagen plays in the body are Neoepitopes of Type V collagen have shown to be a useful noninvasive serum biomarker for assessing fibrotic progression and resolution in experimental hepatic fibrosis 5 Type V Collagens isoform which contains the a3 V chain is involved in mediating pancreatic islet cell functions 5 Type V Collagens will arrange with Type I Collagen and form heterotypic fibrils in the skin dermis and cornea Together Collagen V and Collagen I acts as a dominant regulator of collagen fibrillogenesis 5 Type V Collagens interacts with matrix collagens and structural proteins This interaction improves structural integrity to tissue scaffolds 5 Harmful roles that Type V collagen can play in the body Having a Type V Collagen deficiency has been associated with loss of corneal transparency and classic Ehlers Danlos syndrome 5 Studies have shown that an overexpression of Type V Collagen can lead to harmful responses in the body Collagen V overexpression has been found in cancer granulation tissue inflammation and atherosclerosis It is also linked to fibrosis of the lungs skin kidneys adipose tissue and liver 5 Increases in Type V Collagen are associated with both early and advanced hepatic fibrosis 5 Studies show that increased synthesis of abnormal Type V Collagen is linked to the pathogenesis of Systemic Sclerosis 4 Autoimmunity against type V collagen is associated with lung transplant failure 6 7 8 Genes editCOL5A1 COL5A2 COL5A3References edit Wenstrup RJ Florer JB Brunskill EW Bell SM Chervoneva I Birk DE December 2004 Type V collagen controls the initiation of collagen fibril assembly The Journal of Biological Chemistry 279 51 53331 53337 doi 10 1074 jbc M409622200 PMID 15383546 Malfait F Wenstrup R De Paepe A 1993 Adam MP Mirzaa GM Pagon RA Wallace SE Bean LJ Gripp KW Amemiya A eds Ehlers Danlos Syndrome Classic Type GeneReviews Seattle WA University of Washington Seattle PMID 20301422 a b c d COL5A1 gene MedlinePlus Genetics medlineplus gov Retrieved 2023 04 26 a b Martin Patricia Teodoro Walcy R Velosa Ana Paula P de Morais Jymenez Carrasco Solange Christmann Romy B Goldenstein Schainberg Claudia Parra Edwin R Katayama Maria Lucia Sotto Mirian N Capelozzi Vera L Yoshinari Natalino H September 2012 Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis Autoimmunity Reviews 11 11 827 835 doi 10 1016 j autrev 2012 02 017 ISSN 1873 0183 PMID 22406224 a b c d e f g h i j k Mak Ki M Png Chien Yi M Lee Danielle J May 2016 Type V Collagen in Health Disease and Fibrosis Anatomical Record Hoboken N J 2007 299 5 613 629 doi 10 1002 ar 23330 ISSN 1932 8494 PMID 26910848 Studies on Collagen www collagencomplete com Retrieved 2016 07 13 Haque MA Mizobuchi T Yasufuku K Fujisawa T Brutkiewicz RR Zheng Y et al August 2002 Evidence for immune responses to a self antigen in lung transplantation role of type V collagen specific T cells in the pathogenesis of lung allograft rejection Journal of Immunology 169 3 1542 1549 doi 10 4049 jimmunol 169 3 1542 PMID 12133982 Iwata T Philipovskiy A Fisher AJ Presson RG Chiyo M Lee J et al October 2008 Anti type V collagen humoral immunity in lung transplant primary graft dysfunction Journal of Immunology 181 8 5738 5747 doi 10 4049 jimmunol 181 8 5738 PMC 2997998 PMID 18832733 External links editCollagen Type V at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Type V collagen amp oldid 1170047873, wikipedia, wiki, book, books, library,
