Seminiferous tubules are located within the testicles, and are the specific location of meiosis, and the subsequent creation of male gametes, namely spermatozoa.
Seminiferous tubule
Seminiferous tubule in cross-section (large tubular structure – center of image) with sperm (black, tiny, ovoid bodies furthest from the outer edge of the tubular structure). H&E stain.
In between the Sertoli cells are spermatogenic cells, which differentiate through meiosis to sperm cells. Sertoli cells function to nourish the developing sperm cells. They secrete androgen-binding protein, a binding protein which increases the concentration of testosterone.
There are two types: convoluted and straight, convoluted toward the lateral side, and straight as the tubule comes medially to form ducts that will exit the testis.
The seminiferous tubules are formed from the testis cords that develop from the primitive gonadal cords, formed from the gonadal ridge.
Spermatogenesis, the process for producing spermatozoa, takes place in the seminiferous tubules. During spermatogenesis, the DNA of spermatogenic cells in the seminiferous tubules is subject to damage from such sources as reactive oxygen species.[1] The genomic integrity of spermatogenic cells is protected by DNA repair processes.[2] Deficiencies in the enzymes employed in these repair processes may lead to infertility.[2]
Additional imagesedit
Seminiferous tubule (right) with sperm (black, tiny, ovoid). H&E stain.
Longitudinal section through the left side of the scrotum and the left testis (seminiferous tubules visible in center, but not labeled).
Seminiferous tubule (transverse section).
Photomicrograph of section through rat testis, showing seminiferous tubules.
^Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S, Sabanegh E, Agarwal A (2010). "Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species". Fertil. Steril. 94 (6): 2141–6. doi:10.1016/j.fertnstert.2009.12.030. PMID 20117780.
^ abGunes S, Al-Sadaan M, Agarwal A (2015). "Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility". Reprod. Biomed. Online. 31 (3): 309–19. doi:10.1016/j.rbmo.2015.06.010. PMID 26206278.
External linksedit
Histology image: 17802loa – Histology Learning System at Boston University
seminiferous, tubule, located, within, testicles, specific, location, meiosis, subsequent, creation, male, gametes, namely, spermatozoa, cross, section, large, tubular, structure, center, image, with, sperm, black, tiny, ovoid, bodies, furthest, from, outer, e. Seminiferous tubules are located within the testicles and are the specific location of meiosis and the subsequent creation of male gametes namely spermatozoa Seminiferous tubuleSeminiferous tubule in cross section large tubular structure center of image with sperm black tiny ovoid bodies furthest from the outer edge of the tubular structure H amp E stain 1 Testicular septa2 Convoluted seminiferous tubules3 Testicular lobules4 Straight seminiferous tubules5 Efferent ductules6 Rete testisDetailsIdentifiersLatintubuli seminiferiMeSHD012671TA98A09 3 01 022TA23599FMA19825Anatomical terminology edit on Wikidata Contents 1 Structure 2 Function 3 Additional images 4 See also 5 References 6 External linksStructure editThe epithelium of the tubule consists of a type of sustentacular cells known as Sertoli cells which are tall columnar type cells that line the tubule In between the Sertoli cells are spermatogenic cells which differentiate through meiosis to sperm cells Sertoli cells function to nourish the developing sperm cells They secrete androgen binding protein a binding protein which increases the concentration of testosterone There are two types convoluted and straight convoluted toward the lateral side and straight as the tubule comes medially to form ducts that will exit the testis The seminiferous tubules are formed from the testis cords that develop from the primitive gonadal cords formed from the gonadal ridge Function editMain article Spermatogenesis Spermatogenesis the process for producing spermatozoa takes place in the seminiferous tubules During spermatogenesis the DNA of spermatogenic cells in the seminiferous tubules is subject to damage from such sources as reactive oxygen species 1 The genomic integrity of spermatogenic cells is protected by DNA repair processes 2 Deficiencies in the enzymes employed in these repair processes may lead to infertility 2 Additional images edit nbsp Seminiferous tubule right with sperm black tiny ovoid H amp E stain nbsp Longitudinal section through the left side of the scrotum and the left testis seminiferous tubules visible in center but not labeled nbsp Seminiferous tubule transverse section nbsp Photomicrograph of section through rat testis showing seminiferous tubules See also editLeydig cellsReferences edit Mahfouz R Sharma R Thiyagarajan A Kale V Gupta S Sabanegh E Agarwal A 2010 Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species Fertil Steril 94 6 2141 6 doi 10 1016 j fertnstert 2009 12 030 PMID 20117780 a b Gunes S Al Sadaan M Agarwal A 2015 Spermatogenesis DNA damage and DNA repair mechanisms in male infertility Reprod Biomed Online 31 3 309 19 doi 10 1016 j rbmo 2015 06 010 PMID 26206278 External links editHistology image 17802loa Histology Learning System at Boston University Image Diagram Archived 2007 02 19 at the Wayback Machine Retrieved from https en wikipedia org w index php title Seminiferous tubule amp oldid 1220220022, wikipedia, wiki, book, books, library,
