The trigeminovascular system (TVS) refers to neurons and their axonal projections within the trigeminal nerve that project to the cranial meninges and meningeal blood vessels[1][2] residing on the brain's surface.[3] The term, introduced in 1983[4] denotes also the neuropeptides contained within axons that are released into the meninges[5][6] to target vessels and surrounding cells (e.g., mast cells, macrophages, Schwann cells).
The major drugs used to treat migraine in the 19th and 20th century (ergot alkaloids, triptans) were found by Moskowitz and colleagues[7][6] to inhibit neuropeptide release from TV axons as their major mechanism of action. Because drugs that block the release of neuropeptides from trigeminovascular fibres are therapeutically relevant for relieving migraine headaches (especially CGRP to date), hence, It has been hypothesized that the trigeminovascular system may be involved in migraine headaches.[3][8][9] Studies of the TVS have helped to identify therapeutic targets for migraine including onabotulinum toxin, 5-HT1F receptor agonist (lasmiditan),5-HT1B,D[10] as well as CGRP and its receptor system[11] including both small molecule drugs and biologicals. Numerous experimental studies have established that cortical spreading depolarization, the biological substrate for migraine aura, can discharge trigeminovascular afferents as a cause of head pain and by extension unilateral headache overlying the dysfunctional hemisphere in migraineurs with aura.[12] Hence, the TVS has provided a template for migraine pathophysiology and target for drug discovery.
The history of some discoveries re the TV System are summarised in Ashina, et al.[13]
The Brain Prize for 2021 was awarded to 4 investigators studying the trigeminovascular system and its implications for migraine pathophysiology and treatments.
^Moskowitz, MichaelA.; Romero, Jorge; Reinhard, JohnF.; Melamed, Eldad; Pettibone, DouglasJ. (October 1979). "Neurotransmitters and the Fifth Cranial Nerve: Is There a Relation to the Headache Phase of Migraine?". The Lancet. 314 (8148): 883–885. doi:10.1016/s0140-6736(79)92692-8. ISSN 0140-6736.
^Moskowitz, Michael A. (August 1984). "The neurobiology of vascular head pain". Annals of Neurology. 16 (2): 157–168. doi:10.1002/ana.410160202. ISSN 0364-5134.
^ abMay, A.; Goadsby, P. J. (1999). "The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation". Journal of Cerebral Blood Flow & Metabolism. 19 (2): 115–127. doi:10.1097/00004647-199902000-00001.
^Liu-Chen, Lee-Yuan; Mayberg, Marc R.; Moskowitz, Michael A. (May 1983). "Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats". Brain Research. 268 (1): 162–166. doi:10.1016/0006-8993(83)90402-x. ISSN 0006-8993.
^Moskowitz, M.A.; Brody, M.; Liu-Chen, L.-Y. (August 1983). "In vitro release of immunoreactive substance P from putative afferent nerve endings in bovine pia arachnoid". Neuroscience. 9 (4): 809–814. doi:10.1016/0306-4522(83)90269-5. ISSN 0306-4522.
^ abBuzzi, M (November 1991). "Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion". Neuropharmacology. 30 (11): 1193–1200. doi:10.1016/0028-3908(91)90165-8. ISSN 0028-3908.
^Buzzi, M. Gabriella; Moskowitz, Midiael A. (January 1990). "The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater". British Journal of Pharmacology. 99 (1): 202–206. doi:10.1111/j.1476-5381.1990.tb14679.x. ISSN 0007-1188. PMC1917483. PMID 2158835.
^Fanciullacci, M.; Alessandri, M.; Sicuteri, R.; Marabini, S. (1997). "Responsiveness of the trigeminovascular system to nitroglycerine in cluster headache patients". Brain. 120 (2): 283. doi:10.1093/brain/120.2.283.
^Noseda, R.; Jakubowski, M.; Kainz, V.; Borsook, D.; Burstein, R. (2011). "Cortical Projections of Functionally Identified Thalamic Trigeminovascular Neurons: Implications for Migraine Headache and Its Associated Symptoms". Journal of Neuroscience. 31 (40): 14204–14217. doi:10.1523/JNEUROSCI.3285-11.2011. PMC3501387. PMID 21976505.
^Moskowitz, MA; et al. (November 2022). "Migraine research comes of age in the 21st century". Lancet Neurology. 21 (11): 955–958. doi:10.1016/S1474-4422(22)00398-2.
^Warfvinge, Karin; Edvinsson, Lars (2013-05-13). "Pearls and pitfalls in neural CGRP immunohistochemistry". Cephalalgia. 33 (8): 593–603. doi:10.1177/0333102412472072. ISSN 0333-1024.
^Bolay, Hayrunnisa; Reuter, Uwe; Dunn, Andrew K.; Huang, Zhihong; Boas, David A.; Moskowitz, Michael A. (February 2002). "Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model". Nature Medicine. 8 (2): 136–142. doi:10.1038/nm0202-136. ISSN 1078-8956.
^Ashina, Messoud; Hansen, Jakob Møller; Do, Thien Phu; Melo-Carrillo, Agustin; Burstein, Rami; Moskowitz, Michael A (August 2019). "Migraine and the trigeminovascular system—40 years and counting". Lancet Neurology. 18 (8): 795–804. doi:10.1016/s1474-4422(19)30185-1. ISSN 1474-4422. PMC7164539. PMID 31160203.
External linksedit
Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery, Second Edition by Rajesh Munglani, William K. Schmidt and Chas Bountra, page 321
Functional MRI by Chrit T. W. Moonen, P. A. Bandettini, page 21
Craniofacial dysfunction and pain: manual therapy, assessment and management by Harry Von Piekartz, Lynn Bryden, page 90
May 08, 2024
trigeminovascular, system, trigeminovascular, system, refers, neurons, their, axonal, projections, within, trigeminal, nerve, that, project, cranial, meninges, meningeal, blood, vessels, residing, brain, surface, term, introduced, 1983, denotes, also, neuropep. The trigeminovascular system TVS refers to neurons and their axonal projections within the trigeminal nerve that project to the cranial meninges and meningeal blood vessels 1 2 residing on the brain s surface 3 The term introduced in 1983 4 denotes also the neuropeptides contained within axons that are released into the meninges 5 6 to target vessels and surrounding cells e g mast cells macrophages Schwann cells The major drugs used to treat migraine in the 19th and 20th century ergot alkaloids triptans were found by Moskowitz and colleagues 7 6 to inhibit neuropeptide release from TV axons as their major mechanism of action Because drugs that block the release of neuropeptides from trigeminovascular fibres are therapeutically relevant for relieving migraine headaches especially CGRP to date hence It has been hypothesized that the trigeminovascular system may be involved in migraine headaches 3 8 9 Studies of the TVS have helped to identify therapeutic targets for migraine including onabotulinum toxin 5 HT1F receptor agonist lasmiditan 5 HT1B D 10 as well as CGRP and its receptor system 11 including both small molecule drugs and biologicals Numerous experimental studies have established that cortical spreading depolarization the biological substrate for migraine aura can discharge trigeminovascular afferents as a cause of head pain and by extension unilateral headache overlying the dysfunctional hemisphere in migraineurs with aura 12 Hence the TVS has provided a template for migraine pathophysiology and target for drug discovery The history of some discoveries re the TV System are summarised in Ashina et al 13 The Brain Prize for 2021 was awarded to 4 investigators studying the trigeminovascular system and its implications for migraine pathophysiology and treatments See also editUmbelluloneReferences edit Moskowitz MichaelA Romero Jorge Reinhard JohnF Melamed Eldad Pettibone DouglasJ October 1979 Neurotransmitters and the Fifth Cranial Nerve Is There a Relation to the Headache Phase of Migraine The Lancet 314 8148 883 885 doi 10 1016 s0140 6736 79 92692 8 ISSN 0140 6736 Moskowitz Michael A August 1984 The neurobiology of vascular head pain Annals of Neurology 16 2 157 168 doi 10 1002 ana 410160202 ISSN 0364 5134 a b May A Goadsby P J 1999 The Trigeminovascular System in Humans Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation Journal of Cerebral Blood Flow amp Metabolism 19 2 115 127 doi 10 1097 00004647 199902000 00001 Liu Chen Lee Yuan Mayberg Marc R Moskowitz Michael A May 1983 Immunohistochemical evidence for a substance P containing trigeminovascular pathway to pial arteries in cats Brain Research 268 1 162 166 doi 10 1016 0006 8993 83 90402 x ISSN 0006 8993 Moskowitz M A Brody M Liu Chen L Y August 1983 In vitro release of immunoreactive substance P from putative afferent nerve endings in bovine pia arachnoid Neuroscience 9 4 809 814 doi 10 1016 0306 4522 83 90269 5 ISSN 0306 4522 a b Buzzi M November 1991 Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion Neuropharmacology 30 11 1193 1200 doi 10 1016 0028 3908 91 90165 8 ISSN 0028 3908 Buzzi M Gabriella Moskowitz Midiael A January 1990 The antimigraine drug sumatriptan GR43175 selectively blocks neurogenic plasma extravasation from blood vessels in dura mater British Journal of Pharmacology 99 1 202 206 doi 10 1111 j 1476 5381 1990 tb14679 x ISSN 0007 1188 PMC 1917483 PMID 2158835 Fanciullacci M Alessandri M Sicuteri R Marabini S 1997 Responsiveness of the trigeminovascular system to nitroglycerine in cluster headache patients Brain 120 2 283 doi 10 1093 brain 120 2 283 Noseda R Jakubowski M Kainz V Borsook D Burstein R 2011 Cortical Projections of Functionally Identified Thalamic Trigeminovascular Neurons Implications for Migraine Headache and Its Associated Symptoms Journal of Neuroscience 31 40 14204 14217 doi 10 1523 JNEUROSCI 3285 11 2011 PMC 3501387 PMID 21976505 Moskowitz MA et al November 2022 Migraine research comes of age in the 21st century Lancet Neurology 21 11 955 958 doi 10 1016 S1474 4422 22 00398 2 Warfvinge Karin Edvinsson Lars 2013 05 13 Pearls and pitfalls in neural CGRP immunohistochemistry Cephalalgia 33 8 593 603 doi 10 1177 0333102412472072 ISSN 0333 1024 Bolay Hayrunnisa Reuter Uwe Dunn Andrew K Huang Zhihong Boas David A Moskowitz Michael A February 2002 Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model Nature Medicine 8 2 136 142 doi 10 1038 nm0202 136 ISSN 1078 8956 Ashina Messoud Hansen Jakob Moller Do Thien Phu Melo Carrillo Agustin Burstein Rami Moskowitz Michael A August 2019 Migraine and the trigeminovascular system 40 years and counting Lancet Neurology 18 8 795 804 doi 10 1016 s1474 4422 19 30185 1 ISSN 1474 4422 PMC 7164539 PMID 31160203 External links editPain Current Understanding Emerging Therapies and Novel Approaches to Drug Discovery Second Edition by Rajesh Munglani William K Schmidt and Chas Bountra page 321 Functional MRI by Chrit T W Moonen P A Bandettini page 21 Craniofacial dysfunction and pain manual therapy assessment and management by Harry Von Piekartz Lynn Bryden page 90 Retrieved from https en wikipedia org w index php title Trigeminovascular system amp oldid 1221000108, wikipedia, wiki, book, books, library,
