Clinical history and examination are important. In a significant number of patients there is a familial trait. Examination will white, translucent, slightly raised papules which have a pearly white appearance.
Treatment
Any suspicicion of malignant change calls for adequate excision and histological examination. The only other reason for treatment is cosmetic . Partial destruction is usually followed by regrowth. Many treatment modalities may be used including surgical excision, curettage, cryotherapy and dermabrasion. High-energy pulsed carbon dioxide laser has also been advocated as a useful treatment.
Trichoepitheliomas consists of nests of basaloid cells, with palisading. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma.
^Salhi A, Bornholdt D, Oeffner F, et al. (August 2004). "Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res. 64 (15): 5113–7. doi:10.1158/0008-5472.CAN-04-0307. PMID 15289313. S2CID 16609272.
^James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN0-7216-2921-0.
^Stanoszek, Lauren M.; Wang, Grace Y.; Harms, Paul W. (2017-11-01). "Histologic Mimics of Basal Cell Carcinoma". Archives of Pathology & Laboratory Medicine. 141 (11): 1490–1502. doi:10.5858/arpa.2017-0222-RA. ISSN 0003-9985. PMID 29072946.
External linksedit
April 14, 2024
trichoepithelioma, neoplasm, adnexa, skin, appearance, similar, basal, cell, carcinoma, other, namesbrooke, tumour, epithelioma, afenoides, cysticum, micrograph, trichoepithelioma, stain, specialtydermatologyusual, onsetusually, young, adultsdiagnostic, method. Trichoepithelioma is a neoplasm of the adnexa of the skin 1 Its appearance is similar to basal cell carcinoma TrichoepitheliomaOther namesBrooke s tumour Epithelioma afenoides cysticum Micrograph of a trichoepithelioma H amp E stain SpecialtyDermatologyUsual onsetusually young adultsDiagnostic methodClinical history and examination are important In a significant number of patients there is a familial trait Examination will white translucent slightly raised papules which have a pearly white appearance TreatmentAny suspicicion of malignant change calls for adequate excision and histological examination The only other reason for treatment is cosmetic Partial destruction is usually followed by regrowth Many treatment modalities may be used including surgical excision curettage cryotherapy and dermabrasion High energy pulsed carbon dioxide laser has also been advocated as a useful treatment One form has been mapped to chromosome 9p21 2 Contents 1 Types 2 Pathology 3 Diagnosis 4 See also 5 References 6 External linksTypes editTrichoepitheliomas may be divided into the following types 3 672 Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepitheliomaPathology editTrichoepitheliomas consists of nests of basaloid cells with palisading They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma Mitoses are uncommon when compared to basal cell carcinoma Diagnosis editTrichoepiteliomas often contain Merkel cells an immunostain for CK20 can be used to demonstrate this 4 See also editTrichoblastoma Pilomatricoma CYLD cutaneous syndrome List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromesReferences edit Trichoepithelioma Overview eMedicine Dermatology Retrieved 2009 02 11 Salhi A Bornholdt D Oeffner F et al August 2004 Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene Cancer Res 64 15 5113 7 doi 10 1158 0008 5472 CAN 04 0307 PMID 15289313 S2CID 16609272 James William D Berger Timothy G et al 2006 Andrews Diseases of the Skin Clinical Dermatology Saunders Elsevier ISBN 0 7216 2921 0 Stanoszek Lauren M Wang Grace Y Harms Paul W 2017 11 01 Histologic Mimics of Basal Cell Carcinoma Archives of Pathology amp Laboratory Medicine 141 11 1490 1502 doi 10 5858 arpa 2017 0222 RA ISSN 0003 9985 PMID 29072946 External links edit Retrieved from https en wikipedia org w index php title Trichoepithelioma amp oldid 1092657206, wikipedia, wiki, book, books, library,
