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Treatment of warts by keratolysis

Keratolysis is the removal of dead surface skin cells and is a treatment for several types of wart. The most common keratolytic treatment of warts available over-the-counter involves salicylic acid. These products are readily available at most drugstores and supermarkets. There are typically two types of products: adhesive pads treated with salicylic acid or a bottle of concentrated salicylic acid. Removing a wart with this method requires a strict regimen of cleaning the area, applying the salicylic acid, and removing the dead skin with a pumice stone or emery board. It may take up to 12 weeks to remove a stubborn wart.[citation needed]

Two viral warts on a middle finger, being treated with a mixture of acids to remove them. A white precipitation forms on the area where the product was applied.

Formulations edit

Some formulations are:

  • alcoholic solution containing glycerol
  • collodion which dries to a celluloid film / Duofilm
  • simple ointment
  • absorption ointment
  • oil in water cream

The amount of salicylic acid reaching the wart varies substantially depending on the formulation used.[1] Brands in the UK include Bazuka (Dendron), Scholl (SSL International), Compound W, Cuplex gel, Duofilm (Stiefel), Occlusal (Alliance), Salatac Gel, Salactol Paint, and Verrugon (Ransom).[1][2][additional citation(s) needed]

Molecular basis of therapeutic effect edit

  • Salicylic acid reaches warts; lactic acid and collodion do not.[2] Therefore, these additional components have only an indirect role in therapy.
  • The molecular structure of the skin is altered at the centre of the wart.[3]
  • Experiments indicated that salicylic acid bonding within the human papillomavirus-containing verruca tissue is more likely than simple acid dissociation upon dissolution in water within the tissue.[4]

Complications edit

Some cases of allergic contact dermatitis have been observed when using collodion formulations.[5] This was found to be due to rosin in the collodion.[citation needed]

References edit

  1. ^ J Drug Target. 1998;5(5):343-51. PMID 9771616
  2. ^ Int J Pharm. 1999 Oct 25;188(2):145-53. PMID 10518670
  3. ^ Dermatol Clin. 1990 Jan;8(1):143-6. PMID 2302853
  1. ^ "Bazuka extra strength gel". Netdoctor. Retrieved 9 January 2012.
  2. ^ Nathan, Alan (2010-06-17). "Verrucas". Non-Prescription Medicines. Pharmaceutical Press. p. 286.

External links edit

  • List of brand names in US and Canada

treatment, warts, keratolysis, keratolysis, removal, dead, surface, skin, cells, treatment, several, types, wart, most, common, keratolytic, treatment, warts, available, over, counter, involves, salicylic, acid, these, products, readily, available, most, drugs. Keratolysis is the removal of dead surface skin cells and is a treatment for several types of wart The most common keratolytic treatment of warts available over the counter involves salicylic acid These products are readily available at most drugstores and supermarkets There are typically two types of products adhesive pads treated with salicylic acid or a bottle of concentrated salicylic acid Removing a wart with this method requires a strict regimen of cleaning the area applying the salicylic acid and removing the dead skin with a pumice stone or emery board It may take up to 12 weeks to remove a stubborn wart citation needed Two viral warts on a middle finger being treated with a mixture of acids to remove them A white precipitation forms on the area where the product was applied Contents 1 Formulations 2 Molecular basis of therapeutic effect 3 Complications 4 References 5 External linksFormulations editSome formulations are alcoholic solution containing glycerol collodion which dries to a celluloid film Duofilm simple ointment absorption ointment oil in water creamThe amount of salicylic acid reaching the wart varies substantially depending on the formulation used 1 Brands in the UK include Bazuka Dendron Scholl SSL International Compound W Cuplex gel Duofilm Stiefel Occlusal Alliance Salatac Gel Salactol Paint and Verrugon Ransom 1 2 additional citation s needed Molecular basis of therapeutic effect editSalicylic acid reaches warts lactic acid and collodion do not 2 Therefore these additional components have only an indirect role in therapy The molecular structure of the skin is altered at the centre of the wart 3 Experiments indicated that salicylic acid bonding within the human papillomavirus containing verruca tissue is more likely than simple acid dissociation upon dissolution in water within the tissue 4 Complications editSome cases of allergic contact dermatitis have been observed when using collodion formulations 5 This was found to be due to rosin in the collodion citation needed References edit J Drug Target 1998 5 5 343 51 PMID 9771616 Int J Pharm 1999 Oct 25 188 2 145 53 PMID 10518670 Dermatol Clin 1990 Jan 8 1 143 6 PMID 2302853 Bazuka extra strength gel Netdoctor Retrieved 9 January 2012 Nathan Alan 2010 06 17 Verrucas Non Prescription Medicines Pharmaceutical Press p 286 External links editList of brand names in US and Canada Retrieved from https en wikipedia org w index php title Treatment of warts by keratolysis amp oldid 1130560379, wikipedia, wiki, book, books, library,

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