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Transition (genetics)

January 22, 2023

For other uses, see Transition.

Transition, in genetics and molecular biology, refers to a point mutation that changes a purine nucleotide to another purine (A ↔ G), or a pyrimidine nucleotide to another pyrimidine (C ↔ T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.[1]

Illustration of a transition: each of the 4 nucleotide changes between purines or between pyrimidines (in blue). The 8 other changes are transversions (in red).

Transitions can be caused by oxidative deamination and tautomerization. Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.[2]

5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous deamination. This mechanism is important because it dictates the rarity of CpG islands.

See also

References

  1. ^ Collins DW, Jukes TH (April 1994). "Rates of transition and transversion in coding sequences since the human-rodent divergence". Genomics. 20 (3): 386–96. doi:10.1006/geno.1994.1192. PMID 8034311.
  2. ^ Ebersberger I, Metzler D, Schwarz C, Pääbo S (June 2002). "Genomewide comparison of DNA sequences between humans and chimpanzees". Am. J. Hum. Genet. 70 (6): 1490–7. doi:10.1086/340787. PMC 379137. PMID 11992255.

External links

 
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January 22, 2023
transition, genetics, other, uses, transition, transition, genetics, molecular, biology, refers, point, mutation, that, changes, purine, nucleotide, another, purine, pyrimidine, nucleotide, another, pyrimidine, approximately, three, single, nucleotide, polymor. For other uses see Transition Transition in genetics and molecular biology refers to a point mutation that changes a purine nucleotide to another purine A G or a pyrimidine nucleotide to another pyrimidine C T Approximately two out of three single nucleotide polymorphisms SNPs are transitions 1 Illustration of a transition each of the 4 nucleotide changes between purines or between pyrimidines in blue The 8 other changes are transversions in red Transitions can be caused by oxidative deamination and tautomerization Although there are twice as many possible transversions transitions appear more often in genomes possibly due to the molecular mechanisms that generate them 2 5 Methylcytosine is more prone to transition than unmethylated cytosine due to spontaneous deamination This mechanism is important because it dictates the rarity of CpG islands See also EditTransversionReferences Edit Collins DW Jukes TH April 1994 Rates of transition and transversion in coding sequences since the human rodent divergence Genomics 20 3 386 96 doi 10 1006 geno 1994 1192 PMID 8034311 Ebersberger I Metzler D Schwarz C Paabo S June 2002 Genomewide comparison of DNA sequences between humans and chimpanzees Am J Hum Genet 70 6 1490 7 doi 10 1086 340787 PMC 379137 PMID 11992255 External links Edit Wikimedia Commons has media related to Transition genetics Diagram at mun ca This cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Transition genetics amp oldid 1093281421, wikipedia, wiki, book, books, library,

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