This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources. Find sources: "Toxin and Toxin-Target Database" – news · newspapers · books · scholar · JSTOR(August 2014)
The Toxin and Toxin-Target Database (T3DB),[1][2] also known as the Toxic Exposome Database, is a freely accessible online database of common substances that are toxic to humans, along with their protein, DNA or organ targets. The database currently houses nearly 3,700 toxic compounds or poisons described by nearly 42,000 synonyms. This list includes various groups of toxins, including common pollutants, pesticides, drugs, food toxins, household and industrial/workplace toxins, cigarette toxins, and uremic toxins. These toxic substances are linked to 2,086 corresponding protein/DNA target records. In total there are 42,433 toxic substance-toxin target associations. Each toxic compound record (ToxCard) in T3DB contains nearly 100 data fields and holds information such as chemical properties and descriptors, mechanisms of action, toxicity or lethal dose values, molecular and cellular interactions, medical (symptom and treatment) information (Fig. 1–3), NMR an MS spectra, and up- and down-regulated genes. This information has been extracted from over 18,000 sources, which include other databases, government documents, books, and scientific literature.
Toxin and Toxin-Target Database
Content
Description
Toxin and toxin target database
Data types captured
Small molecule poisons, toxic compounds and toxins, chemical structures, toxic compound descriptions, chemical taxonomy, toxin targets and transporters, target protein sequences, mechanisms of action, lethal doses, chemical properties, nomenclature, synonyms, NMR spectra, MS spectra, gene regulation, concentrations
Every 3-4 years with periodic corrections and updates
Curation policy
Manually curated
The primary focus of the T3DB is on providing mechanisms of toxicity and identifying target proteins for common toxic substances. While a number of other toxic compound databases do exist, their emphasis is on covering large numbers of chemical compounds that are almost never seen outside a chemical laboratory. T3DB attempts to capture data on only those toxic substances that are abundant or in widespread use and have been detected or measured in humans. T3DB is fully searchable and supports extensive text, sequence, chemical structure, relational query and spectral searches. It is both modelled after and closely linked to the Human Metabolome Database (HMDB) and DrugBank. Potential applications of T3DB include metabolomics and environmental exposure studies, toxic compound metabolism prediction, toxin/drug interaction prediction, and general toxic substance awareness.
Fig. 1. T3DB Arsenic toxicity
Scope and accessedit
All data in T3DB is non-proprietary or is derived from a non-proprietary source. It is freely accessible and available to anyone. In addition, nearly every data item is fully traceable and explicitly referenced to the original source. T3DB data is available through a public web interface and downloads.
^ abWishart, D; Arndt D; Pon A; Sajed T; Guo AC; Djoumbou Y; Knox C; Wilson M; Liang Y; Grant J; Liu Y; Goldansaz SA; Rappaport SM. (Jan 2015). "T3DB: the toxic exposome database". Nucleic Acids Research. 43 (Database issue): D928-34. doi:10.1093/nar/gku1004. PMC4383875. PMID 25378312.
^Lim, E; Pon A; Djoumbou Y; Knox C; Shrivastava S; Guo AC; Neveu V; Wishart DS. (Jan 2010). "T3DB: a comprehensively annotated database of common toxins and their targets". Nucleic Acids Research. 38 (Database issue): D781-6. doi:10.1093/nar/gkp934. PMC2808899. PMID 19897546.
April 12, 2024
toxin, toxin, target, database, this, article, relies, largely, entirely, single, source, relevant, discussion, found, talk, page, please, help, improve, this, article, introducing, citations, additional, sources, find, sources, news, newspapers, books, schola. This article relies largely or entirely on a single source Relevant discussion may be found on the talk page Please help improve this article by introducing citations to additional sources Find sources Toxin and Toxin Target Database news newspapers books scholar JSTOR August 2014 The Toxin and Toxin Target Database T3DB 1 2 also known as the Toxic Exposome Database is a freely accessible online database of common substances that are toxic to humans along with their protein DNA or organ targets The database currently houses nearly 3 700 toxic compounds or poisons described by nearly 42 000 synonyms This list includes various groups of toxins including common pollutants pesticides drugs food toxins household and industrial workplace toxins cigarette toxins and uremic toxins These toxic substances are linked to 2 086 corresponding protein DNA target records In total there are 42 433 toxic substance toxin target associations Each toxic compound record ToxCard in T3DB contains nearly 100 data fields and holds information such as chemical properties and descriptors mechanisms of action toxicity or lethal dose values molecular and cellular interactions medical symptom and treatment information Fig 1 3 NMR an MS spectra and up and down regulated genes This information has been extracted from over 18 000 sources which include other databases government documents books and scientific literature Toxin and Toxin Target DatabaseContentDescriptionToxin and toxin target databaseData typescapturedSmall molecule poisons toxic compounds and toxins chemical structures toxic compound descriptions chemical taxonomy toxin targets and transporters target protein sequences mechanisms of action lethal doses chemical properties nomenclature synonyms NMR spectra MS spectra gene regulation concentrationsContactResearch centerUniversity of Alberta and The Metabolomics Innovation CentreLaboratoryDavid S WishartPrimary citationT3DB the toxic exposome database 1 Release date2009AccessWebsitehttp www t3db caDownload URLhttp www t3db ca downloadsMiscellaneousData releasefrequencyEvery 3 4 years with periodic corrections and updatesCuration policyManually curatedThe primary focus of the T3DB is on providing mechanisms of toxicity and identifying target proteins for common toxic substances While a number of other toxic compound databases do exist their emphasis is on covering large numbers of chemical compounds that are almost never seen outside a chemical laboratory T3DB attempts to capture data on only those toxic substances that are abundant or in widespread use and have been detected or measured in humans T3DB is fully searchable and supports extensive text sequence chemical structure relational query and spectral searches It is both modelled after and closely linked to the Human Metabolome Database HMDB and DrugBank Potential applications of T3DB include metabolomics and environmental exposure studies toxic compound metabolism prediction toxin drug interaction prediction and general toxic substance awareness Fig 1 T3DB Arsenic toxicityScope and access editAll data in T3DB is non proprietary or is derived from a non proprietary source It is freely accessible and available to anyone In addition nearly every data item is fully traceable and explicitly referenced to the original source T3DB data is available through a public web interface and downloads See also editPoison Toxin List of extremely hazardous substances List of biological databases KEGG HMDB SMPDBReferences edit a b Wishart D Arndt D Pon A Sajed T Guo AC Djoumbou Y Knox C Wilson M Liang Y Grant J Liu Y Goldansaz SA Rappaport SM Jan 2015 T3DB the toxic exposome database Nucleic Acids Research 43 Database issue D928 34 doi 10 1093 nar gku1004 PMC 4383875 PMID 25378312 Lim E Pon A Djoumbou Y Knox C Shrivastava S Guo AC Neveu V Wishart DS Jan 2010 T3DB a comprehensively annotated database of common toxins and their targets Nucleic Acids Research 38 Database issue D781 6 doi 10 1093 nar gkp934 PMC 2808899 PMID 19897546 Retrieved from https en wikipedia org w index php title Toxin and Toxin Target Database amp oldid 1197200184, wikipedia, wiki, book, books, library,
