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Tony Minson

December 15, 2023

Anthony (Tony) Charles Minson, PhD, FMedSci (born 8 February 1944)[3] is a British virologist known for his work on the biology of herpesviruses,[4][5][6][7][8] and a university administrator. He was the Senior Pro-Vice-Chancellor of the University of Cambridge from 2003 to 2009. He is an emeritus professor of virology at the university's Department of Pathology and an emeritus fellow of Wolfson College.[9]

Tony Minson
Born (1944-02-08) 8 February 1944 (age 79)[2]
Ilford, Essex, England, UK
Alma materUniversity of Birmingham (BSc)
Australian National University (PhD)
AwardsFMedSci (2002)
Scientific career
InstitutionsUniversity of Cambridge
University of Birmingham
Australian National University
ThesisStudies of the biosynthesis of histidine in Neurospora crassa (1968)
Doctoral studentsTony Kouzarides[1]
Websitewww.wolfson.cam.ac.uk/people/professor-anthony-minson

Education and career edit

Born in Ilford, Essex, Minson was educated at Ilford High School[2] and went on to study microbiology at the University of Birmingham in 1965. His postgraduate work was at the Research School of Biological Sciences of the Australian National University, researching fungal genetics with E. H. Creaser.[10][11][12] He gained his PhD in 1968 for work on the biosynthesis of histidine in Neurospora crassa.[13]

By the early 1970s, Minson had returned to the University of Birmingham.[14] In 1976, he took up a position as Senior Research Associate at the University of Cambridge. In the mid-1980s, he became head of the Division of Virology and, in 1991, was appointed professor of virology in the Department of Pathology.[10] He is a fellow of Wolfson College.[11]

Research edit

 
Herpes simplex virus

Since moving to Cambridge, Minson's research has focused on animal viruses, particularly those of the herpesvirus family, including herpes simplex virus (HSV) and human cytomegalovirus.[15] These large and complex enveloped DNA viruses commonly infect humans, causing a lifelong latent infection. Conditions associated with HSV include cold sores and genital herpes, and both HSV and cytomegalovirus can be life-threatening in immunodeficient people. Much of Minson's research has investigated herpesvirus replication and life cycle, viral pathogenesis and the immune response. His work has contributed to understanding the processes by which HSV fuses with the cell membrane and acquires its envelope.[16][17] As of 2013, his research focuses on herpesvirus entry, in particular how the viral membrane proteins cooperate to induce fusion, as well as assembly, in particular of the viral membrane proteins.[18]

Minson has also worked in collaboration with Margaret Stanley on another DNA virus, human papillomavirus, which is associated with cervical cancer.[19] His research in the early 1970s was in the field of plant viruses, including tobacco rattle virus and tobacco necrosis virus, in collaboration with Graham Darby and others.[14][20] Leszek Borysiewicz and Geoffrey L. Smith are among his other research collaborators,[15][21] and notable students have included Tony Kouzarides.[1][22]

Vaccines edit

In the early 1990s, Minson's group was one of several investigating a novel method of attenuating viruses for use in live vaccines. One or more of the genes absolutely required for replication is deleted and the virus is grown in a cell line engineered to express these gene products. The resulting virus can infect normal human cells but should be safe because it cannot replicate in them.[23][24][25] Such replication-impaired viruses unite many of the advantages of both live and killed virus vaccines and are much less likely to revert to a more virulent form than earlier methods of attenuation.[25][26]

Minson and co-workers pioneered a modification of this approach in which the disabled virus is restricted to a single cycle of replication. Using HSV-2, which causes genital herpes, they disabled the virus by deleting the viral gene encoding the membrane protein glycoprotein H (gH). This product is not required until after the viral assembly process, which means that the disabled virus can undergo a single round of replication in normal human cells, but the progeny virus cannot infect new cells. Minson's group called the resulting virus a "disabled infectious single cycle" (DISC) virus; similarly disabled viruses are also termed "single-cycle" viruses. Their work with DISC HSV-2 led to a series of vaccine candidates, which were developed by Cantab Pharmaceuticals.[23][24][25] The DISC HSV-2 vaccine was promising in animal models and early clinical trials, appearing safe and well tolerated, and eliciting appropriate immune responses.[24][25][27][28] However, a large phase II trial of the agent as a therapeutic vaccine in people with genital herpes failed to demonstrate any benefit,[24][27] and further development has concentrated on the DISC HSV-2 vaccine's potential to prevent infection.[27][29] The single-cycle strategy can be used to generate live vaccines against other viruses, and such a vaccine has recently been successfully developed for the bluetongue virus of sheep.[30] Single-cycle viruses are also widely used as vaccine vectors, carrying genes from other viruses.[31]

Detection edit

In the early 2000s, a collaboration between Minson and Matthew Cooper's group from the University of Cambridge's chemistry department pioneered a novel acoustic technique for detecting viruses. The technique allows a single virus particle to be detected in a sample and has the potential for use as a quick yet sensitive monitor of viral infection.[32][33] The researchers co-founded the company Akubio in 2001 to exploit the discovery; the company developed biosensors for detecting bacteria and viruses. It was acquired by Inverness Medical Innovations in 2008.[34]

Taxonomy edit

Minson is a long-term member of the International Committee on Taxonomy of Viruses (ICTV) Study Group that defines herpesvirus taxonomy.[35][36] In 2008, as a result of the group's deliberations on research into herpesvirus genetics, the ICTV promoted the herpesvirus family to an order and split it into three families.[36]

Science and university administration edit

 
Senate House, centre of the university's government, lit up for the 800th anniversary

Minson has been highly active in university administration. In 2001–3, he chaired the School of Biological Sciences, one of the six schools of the University of Cambridge.[11] In 2003, he was appointed Pro-Vice-Chancellor of the university, in succession to Malcolm Grant. Minson was the first, and most senior, of a new team of five Pro-Vice-Chancellors, holding particular responsibility for planning and resources.[10][37][38] He said of his role: We have a duty to maintain the university's values of scientific enquiry and scholarship whilst embracing the principles of sustainable, achievable reform.[38] He served in this position until 2009, the university's 800th anniversary year.[37] Soon after his appointment, he was thrown into controversy over his strong support for a proposed new primate research centre attached to the university, which was the target of a campaign by animal rights activists.[39] The plans were later abandoned because of escalating costs, due in part to the activism.[40][41] In 2005, the university launched a major fund-raising campaign to mark the 800th anniversary; the £1 billion target was achieved ahead of schedule in 2010.[42]

Minson has also served on the steering committee of the multidisciplinary Cambridge Infectious Disease group, launched in 2004.[43][44] In 2010–12, he chaired the syndicate governing Cambridge University Press.[45] Outside the university, he served on the council of the Society for General Microbiology in 1990–94 and 2003–7, and (as of 2012) is the reviews editor of their journal, the Journal of General Virology.[46][47] He was an officer of the Biotechnology and Biological Sciences Research Council's Institute for Animal Health (now the Pirbright Institute) from 1997–2003.[48] As of 2013, Minson is on the board of the Lister Institute of Preventive Medicine and is a trustee of the Animal Health Trust.[49][50]

He has drawn attention to the cost of bureaucracy imposed on researchers by government agencies, writing in 2004:

To be against improvement in standards is like being against motherhood, but we should be alert to the dangers of universal codes of practice imposed for administrative tidiness. The fact is that the great scientific leaps of the past 50 years have not been made in laboratories using validated standard operating procedures, well-defined line-management systems, and 6-monthly milestones.[51]

Awards and honours edit

Minson was elected a fellow of the Academy of Medical Sciences in 2002.[52] He was elected an honorary member of the Society for General Microbiology in 2011.[46]

References edit

  1. ^ a b Laursen, L. (2008). "Creativity and Persistence Overcome Failure: Tony Kouzarides tells the story of his early career as a comedy of errors". Science. doi:10.1126/science.caredit.a0800097.
  2. ^ a b "MINSON, Prof. Anthony Charles". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press.(subscription required)
  3. ^ Companies in the UK: Professor Anthony Charles Minson (accessed 9 January 2013)
  4. ^ Parry, C.; Bell, S.; Minson, T.; Browne, H. (2005). "Herpes simplex virus type 1 glycoprotein H binds to v 3 integrins". Journal of General Virology. 86 (Pt 1): 7–10. doi:10.1099/vir.0.80567-0. PMID 15604426.
  5. ^ Skepper, J. N.; Whiteley, A.; Browne, H.; Minson, A. (2001). "Herpes Simplex Virus Nucleocapsids Mature to Progeny Virions by an Envelopment Deenvelopment Reenvelopment Pathway". Journal of Virology. 75 (12): 5697–5702. doi:10.1128/JVI.75.12.5697-5702.2001. PMC 114284. PMID 11356979.
  6. ^ Turner, A.; Bruun, B.; Minson, T.; Browne, H. (1998). "Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system". Journal of Virology. 72 (1): 873–875. doi:10.1128/JVI.72.1.873-875.1998. PMC 109452. PMID 9420303.
  7. ^ McLean, C. S.; Erturk, M.; Jennings, R.; Challanain, D. N.; Minson, A. C.; Duncan, I.; Boursnell, M. E.; Inglis, S. C. (1994). "Protective vaccination against primary and recurrent disease caused by herpes simplex virus (HSV) type 2 using a genetically disabled HSV-1". The Journal of Infectious Diseases. 170 (5): 1100–1109. doi:10.1093/infdis/170.5.1100. PMID 7963701.
  8. ^ Forrester, A.; Farrell, H.; Wilkinson, G.; Kaye, J.; Davis-Poynter, N.; Minson, T. (1992). "Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted". Journal of Virology. 66 (1): 341–348. doi:10.1128/JVI.66.1.341-348.1992. PMC 238293. PMID 1309250.
  9. ^ Mitchinson, M. J. Arno J, Edwards PAW, LePage RWF, Minson AC (1996). Essentials of pathology. Oxford: Blackwell Science. ISBN 0-632-02944-7.{{cite book}}: CS1 maint: multiple names: authors list (link)
  10. ^ a b c University of Cambridge: News and Events: New Pro-Vice-Chancellor appointed (16 June 2003) (accessed 5 January 2009)
  11. ^ a b c Wolfson College, Cambridge: Professor Anthony Minson (accessed 7 January 2013)
  12. ^ Minson, A. C.; Creaser, E. H. (1969). "Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa". The Biochemical Journal. 114 (1): 49–56. doi:10.1042/bj1140049. PMC 1184794. PMID 4309307.
  13. ^ Minson, Anthony Charles (1968). Studies of the biosynthesis of histidine in Neurospora crassa (PhD thesis). Australian National University.
  14. ^ a b Darby, G.; Minson, A. C. (1973). "The Structure of Tobacco Rattle Virus Ribonucleic Acids: Common Nucleotide Sequences in the RNA Species". Journal of General Virology. 21 (2): 285–295. doi:10.1099/0022-1317-21-2-285.
  15. ^ a b Browne, H.; Smith, G.; Beck, S.; Minson, T. (1990). "A complex between the MHC class I homologue encoded by human cytomegalovirus and β2 microglobulin". Nature. 347 (6295): 770–772. Bibcode:1990Natur.347..770B. doi:10.1038/347770a0. PMID 2172831. S2CID 4249803.
  16. ^ rae2008: UOA 3 - Infection and Immunology: University of Cambridge: RA5a: Research environment and esteem (accessed 14 January 2013)
  17. ^ Herpes simplex virus Research: HSV Replication Archived 2012-12-12 at archive.today (accessed 9 January 2013)
  18. ^ University of Cambridge: Department of Pathology: Professor Tony Minson & Dr Helena Browne 2009-02-21 at the Wayback Machine (accessed 10 January 2013)
  19. ^ Stanley, M. A.; Browne, H. M.; Appleby, M.; Minson, A. C. (1989). "Properties of a non-tumorigenic human cervical keratinocyte cell line". International Journal of Cancer. 43 (4): 672–676. doi:10.1002/ijc.2910430422. PMID 2467886. S2CID 25064033.
  20. ^ Shoulder, A.; Darby, G.; Minson, T. (1974). "RNA—RNA hybridisation using 125I-labelled RNA from tobacco necrosis virus and its satellite". Nature. 251 (5477): 733–735. Bibcode:1974Natur.251..733S. doi:10.1038/251733a0. PMID 4427674. S2CID 4288038.
  21. ^ Bell, S.; Cranage, M.; Borysiewicz, L.; Minson, T. (1990). "Induction of immunoglobulin G Fc receptors by recombinant vaccinia viruses expressing glycoproteins E and I of herpes simplex virus type 1". Journal of Virology. 64 (5): 2181–2186. doi:10.1128/JVI.64.5.2181-2186.1990. PMC 249377. PMID 2157879.
  22. ^ Cranage, M. P.; Kouzarides, T.; Bankier, A. T.; Satchwell, S.; Weston, K.; Tomlinson, P.; Barrell, B.; Hart, H.; Bell, S. E.; Minson, A. C. (1986). "Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus". The EMBO Journal. 5 (11): 3057–3063. doi:10.1002/j.1460-2075.1986.tb04606.x. PMC 1167261. PMID 3024973.
  23. ^ a b Stanberry LR. Understanding Herpes: A Concise Overview of Recent Advances and New Resources, p. 98 (2nd edn) (University Press of Mississippi; 2006) (Googlebooks)
  24. ^ a b c d Koelle, D. M.; Corey, L. (2003). "Recent progress in herpes simplex virus immunobiology and vaccine research". Clinical Microbiology Reviews. 16 (1): 96–113. doi:10.1128/CMR.16.1.96-113.2003. PMC 145296. PMID 12525427.
  25. ^ a b c d Dudek, T.; Knipe, D. M. (2006). "Replication-defective viruses as vaccines and vaccine vectors". Virology. 344 (1): 230–239. doi:10.1016/j.virol.2005.09.020. PMID 16364753.
  26. ^ Gregoriadis G, McCormack B, Allison AC (eds). Vaccine Design: The Role of Cytokine Networks, pp. 120–122, (Plenum Press; 1997) (ISBN 0306458187)
  27. ^ a b c (accessed 10 January 2013)
  28. ^ Whitley, R. J.; Roizman, B. (2002). "Herpes simplex viruses: Is a vaccine tenable?". Journal of Clinical Investigation. 110 (2): 145–151. doi:10.1172/JCI16126. PMC 151069. PMID 12122103.
  29. ^ Gross G, Tyring SK (eds) Sexually Transmitted Infections and Sexually Transmitted Diseases, p. 698 (Springer; 2011) (ISBN 978-3-642-14662-6
  30. ^ Matsuo, E.; Celma, C. C. P.; Boyce, M.; Viarouge, C.; Sailleau, C.; Dubois, E.; Bréard, E.; Thiéry, R.; Zientara, S.; Roy, P. (2011). "Generation of Replication-Defective Virus-Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus Challenge". Journal of Virology. 85 (19): 10213–10221. doi:10.1128/JVI.05412-11. PMC 3196398. PMID 21795358.
  31. ^ Gomme, E. A.; Faul, E. J.; Flomenberg, P.; McGettigan, J. P.; Schnell, M. J. (2010). "Characterization of a Single-Cycle Rabies Virus-Based Vaccine Vector". Journal of Virology. 84 (6): 2820–2831. doi:10.1128/JVI.01870-09. PMC 2826042. PMID 20053743.
  32. ^ Cooper, M. A.; Dultsev, F. N.; Minson, T.; Ostanin, V. P.; Abell, C.; Klenerman, D. (2001). "Direct and sensitive detection of a human virus by rupture event scanning". Nature Biotechnology. 19 (9): 833–837. doi:10.1038/nbt0901-833. PMID 11533641. S2CID 7307876.
  33. ^ Anon (2001). "Direct and sensitive detection of a human virus by rupture event scanning: researchers hope to hear HIV, hepatitis and 'flu". Nature. doi:10.1038/news010906-1.
  34. ^ Vargas L. Recycled Cambridge biosensor technology attracts millions in investment Business Weekly (27 August 2008) (accessed 9 January 2013)
  35. ^ Roizmann, B.; Desrosiers, R. C.; Fleckenstein, B.; Lopez, C.; Minson, A. C.; Studdert, M. J. (1992). "The familyHerpesviridae: An update". Archives of Virology. 123 (3–4): 425–449. doi:10.1007/BF01317276. PMID 1562239.
  36. ^ a b Davison, A. J.; Eberle, R.; Ehlers, B.; Hayward, G. S.; McGeoch, D. J.; Minson, A. C.; Pellett, P. E.; Roizman, B.; Studdert, M. J.; Thiry, E. (2008). "The order Herpesvirales". Archives of Virology. 154 (1): 171–177. doi:10.1007/s00705-008-0278-4. PMC 3552636. PMID 19066710.
  37. ^ a b The Reporter: Office of Pro-Vice-Chancellor (Planning and Resources): Notice (accessed 9 January 2013)
  38. ^ a b Guardian: Cambridge appoints new pro-vice-chancellor (accessed 9 January 2013)
  39. ^ Times Higher Education: In the news: Tony Minson (accessed 9 January 2013)
  40. ^ Anon (2004). "A defeat for primate research". Nature Neuroscience. 7 (5): 413. doi:10.1038/nn0504-413. PMID 15114345.
  41. ^ Guardian: Cambridge abandons plans for primate lab (accessed 9 January 2013
  42. ^ Cambridge University Development Office: While the 800th Anniversary Campaign has been completed, Cambridge's fundraising continues (accessed 10 January 2013)
  43. ^ . Archived from the original on February 28, 2009. Retrieved 2009-01-05.{{cite web}}: CS1 maint: bot: original URL status unknown (link) (accessed 9 January 2013)
  44. ^ Cambridge Infectious Diseases: About Us (accessed 10 January 2013)
  45. ^ Cambridge University Press: Annual Report for the year ended 30 April 2012[permanent dead link] (accessed 7 January 2013)
  46. ^ a b Society for General Microbiology: Membership: Honorary 2012-09-05 at the Wayback Machine (accessed 9 January 2013)
  47. ^ Journal of General Virology: JGV Editors 2012 Archived 2013-04-15 at archive.today (accessed 9 January 2013)
  48. ^ Open Corporates: The Pirbright Institute (accessed 9 January 2013)
  49. ^ The Lister Institute of Preventive Medicine: Organisation 2012-12-14 at the Wayback Machine (accessed 7 January 2013)
  50. ^ Animal Health Trust: Frequently Asked Questions (accessed 8 January 2013)
  51. ^ Minson T. (2004) Comment: Codes of practice in research. Microbiol Today 31: 156 (pdf[permanent dead link])
  52. ^ Academy of Medical Sciences: Fellows (accessed 5 January 2009)

External links edit

    December 15, 2023
    tony, minson, anthony, tony, charles, minson, fmedsci, born, february, 1944, british, virologist, known, work, biology, herpesviruses, university, administrator, senior, vice, chancellor, university, cambridge, from, 2003, 2009, emeritus, professor, virology, . Anthony Tony Charles Minson PhD FMedSci born 8 February 1944 3 is a British virologist known for his work on the biology of herpesviruses 4 5 6 7 8 and a university administrator He was the Senior Pro Vice Chancellor of the University of Cambridge from 2003 to 2009 He is an emeritus professor of virology at the university s Department of Pathology and an emeritus fellow of Wolfson College 9 Tony MinsonBorn 1944 02 08 8 February 1944 age 79 2 Ilford Essex England UKAlma materUniversity of Birmingham BSc Australian National University PhD AwardsFMedSci 2002 Scientific careerInstitutionsUniversity of CambridgeUniversity of BirminghamAustralian National UniversityThesisStudies of the biosynthesis of histidine in Neurospora crassa 1968 Doctoral studentsTony Kouzarides 1 Websitewww wbr wolfson wbr cam wbr ac wbr uk wbr people wbr professor anthony minson Contents 1 Education and career 2 Research 2 1 Vaccines 2 2 Detection 2 3 Taxonomy 3 Science and university administration 4 Awards and honours 5 References 6 External linksEducation and career editBorn in Ilford Essex Minson was educated at Ilford High School 2 and went on to study microbiology at the University of Birmingham in 1965 His postgraduate work was at the Research School of Biological Sciences of the Australian National University researching fungal genetics with E H Creaser 10 11 12 He gained his PhD in 1968 for work on the biosynthesis of histidine in Neurospora crassa 13 By the early 1970s Minson had returned to the University of Birmingham 14 In 1976 he took up a position as Senior Research Associate at the University of Cambridge In the mid 1980s he became head of the Division of Virology and in 1991 was appointed professor of virology in the Department of Pathology 10 He is a fellow of Wolfson College 11 Research edit nbsp Herpes simplex virusSince moving to Cambridge Minson s research has focused on animal viruses particularly those of the herpesvirus family including herpes simplex virus HSV and human cytomegalovirus 15 These large and complex enveloped DNA viruses commonly infect humans causing a lifelong latent infection Conditions associated with HSV include cold sores and genital herpes and both HSV and cytomegalovirus can be life threatening in immunodeficient people Much of Minson s research has investigated herpesvirus replication and life cycle viral pathogenesis and the immune response His work has contributed to understanding the processes by which HSV fuses with the cell membrane and acquires its envelope 16 17 As of 2013 his research focuses on herpesvirus entry in particular how the viral membrane proteins cooperate to induce fusion as well as assembly in particular of the viral membrane proteins 18 Minson has also worked in collaboration with Margaret Stanley on another DNA virus human papillomavirus which is associated with cervical cancer 19 His research in the early 1970s was in the field of plant viruses including tobacco rattle virus and tobacco necrosis virus in collaboration with Graham Darby and others 14 20 Leszek Borysiewicz and Geoffrey L Smith are among his other research collaborators 15 21 and notable students have included Tony Kouzarides 1 22 Vaccines edit In the early 1990s Minson s group was one of several investigating a novel method of attenuating viruses for use in live vaccines One or more of the genes absolutely required for replication is deleted and the virus is grown in a cell line engineered to express these gene products The resulting virus can infect normal human cells but should be safe because it cannot replicate in them 23 24 25 Such replication impaired viruses unite many of the advantages of both live and killed virus vaccines and are much less likely to revert to a more virulent form than earlier methods of attenuation 25 26 Minson and co workers pioneered a modification of this approach in which the disabled virus is restricted to a single cycle of replication Using HSV 2 which causes genital herpes they disabled the virus by deleting the viral gene encoding the membrane protein glycoprotein H gH This product is not required until after the viral assembly process which means that the disabled virus can undergo a single round of replication in normal human cells but the progeny virus cannot infect new cells Minson s group called the resulting virus a disabled infectious single cycle DISC virus similarly disabled viruses are also termed single cycle viruses Their work with DISC HSV 2 led to a series of vaccine candidates which were developed by Cantab Pharmaceuticals 23 24 25 The DISC HSV 2 vaccine was promising in animal models and early clinical trials appearing safe and well tolerated and eliciting appropriate immune responses 24 25 27 28 However a large phase II trial of the agent as a therapeutic vaccine in people with genital herpes failed to demonstrate any benefit 24 27 and further development has concentrated on the DISC HSV 2 vaccine s potential to prevent infection 27 29 The single cycle strategy can be used to generate live vaccines against other viruses and such a vaccine has recently been successfully developed for the bluetongue virus of sheep 30 Single cycle viruses are also widely used as vaccine vectors carrying genes from other viruses 31 Detection edit In the early 2000s a collaboration between Minson and Matthew Cooper s group from the University of Cambridge s chemistry department pioneered a novel acoustic technique for detecting viruses The technique allows a single virus particle to be detected in a sample and has the potential for use as a quick yet sensitive monitor of viral infection 32 33 The researchers co founded the company Akubio in 2001 to exploit the discovery the company developed biosensors for detecting bacteria and viruses It was acquired by Inverness Medical Innovations in 2008 34 Taxonomy edit Minson is a long term member of the International Committee on Taxonomy of Viruses ICTV Study Group that defines herpesvirus taxonomy 35 36 In 2008 as a result of the group s deliberations on research into herpesvirus genetics the ICTV promoted the herpesvirus family to an order and split it into three families 36 Science and university administration edit nbsp Senate House centre of the university s government lit up for the 800th anniversaryMinson has been highly active in university administration In 2001 3 he chaired the School of Biological Sciences one of the six schools of the University of Cambridge 11 In 2003 he was appointed Pro Vice Chancellor of the university in succession to Malcolm Grant Minson was the first and most senior of a new team of five Pro Vice Chancellors holding particular responsibility for planning and resources 10 37 38 He said of his role We have a duty to maintain the university s values of scientific enquiry and scholarship whilst embracing the principles of sustainable achievable reform 38 He served in this position until 2009 the university s 800th anniversary year 37 Soon after his appointment he was thrown into controversy over his strong support for a proposed new primate research centre attached to the university which was the target of a campaign by animal rights activists 39 The plans were later abandoned because of escalating costs due in part to the activism 40 41 In 2005 the university launched a major fund raising campaign to mark the 800th anniversary the 1 billion target was achieved ahead of schedule in 2010 42 Minson has also served on the steering committee of the multidisciplinary Cambridge Infectious Disease group launched in 2004 43 44 In 2010 12 he chaired the syndicate governing Cambridge University Press 45 Outside the university he served on the council of the Society for General Microbiology in 1990 94 and 2003 7 and as of 2012 is the reviews editor of their journal the Journal of General Virology 46 47 He was an officer of the Biotechnology and Biological Sciences Research Council s Institute for Animal Health now the Pirbright Institute from 1997 2003 48 As of 2013 Minson is on the board of the Lister Institute of Preventive Medicine and is a trustee of the Animal Health Trust 49 50 He has drawn attention to the cost of bureaucracy imposed on researchers by government agencies writing in 2004 To be against improvement in standards is like being against motherhood but we should be alert to the dangers of universal codes of practice imposed for administrative tidiness The fact is that the great scientific leaps of the past 50 years have not been made in laboratories using validated standard operating procedures well defined line management systems and 6 monthly milestones 51 Awards and honours editMinson was elected a fellow of the Academy of Medical Sciences in 2002 52 He was elected an honorary member of the Society for General Microbiology in 2011 46 References edit a b Laursen L 2008 Creativity and Persistence Overcome Failure Tony Kouzarides tells the story of his early career as a comedy of errors Science doi 10 1126 science caredit a0800097 a b MINSON Prof Anthony Charles Who s Who 2013 A amp C Black an imprint of Bloomsbury Publishing plc 2013 online edn Oxford University Press subscription required Companies in the UK Professor Anthony Charles Minson accessed 9 January 2013 Parry C Bell S Minson T Browne H 2005 Herpes simplex virus type 1 glycoprotein H binds to v 3 integrins Journal of General Virology 86 Pt 1 7 10 doi 10 1099 vir 0 80567 0 PMID 15604426 Skepper J N Whiteley A Browne H Minson A 2001 Herpes Simplex Virus Nucleocapsids Mature to Progeny Virions by an Envelopment Deenvelopment Reenvelopment Pathway Journal of Virology 75 12 5697 5702 doi 10 1128 JVI 75 12 5697 5702 2001 PMC 114284 PMID 11356979 Turner A Bruun B Minson T Browne H 1998 Glycoproteins gB gD and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system Journal of Virology 72 1 873 875 doi 10 1128 JVI 72 1 873 875 1998 PMC 109452 PMID 9420303 McLean C S Erturk M Jennings R Challanain D N Minson A C Duncan I Boursnell M E Inglis S C 1994 Protective vaccination against primary and recurrent disease caused by herpes simplex virus HSV type 2 using a genetically disabled HSV 1 The Journal of Infectious Diseases 170 5 1100 1109 doi 10 1093 infdis 170 5 1100 PMID 7963701 Forrester A Farrell H Wilkinson G Kaye J Davis Poynter N Minson T 1992 Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted Journal of Virology 66 1 341 348 doi 10 1128 JVI 66 1 341 348 1992 PMC 238293 PMID 1309250 Mitchinson M J Arno J Edwards PAW LePage RWF Minson AC 1996 Essentials of pathology Oxford Blackwell Science ISBN 0 632 02944 7 a href Template Cite book html title Template Cite book cite book a CS1 maint multiple names authors list link a b c University of Cambridge News and Events New Pro Vice Chancellor appointed 16 June 2003 accessed 5 January 2009 a b c Wolfson College Cambridge Professor Anthony Minson accessed 7 January 2013 Minson A C Creaser E H 1969 Purification of a trifunctional enzyme catalysing three steps of the histidine pathway from Neurospora crassa The Biochemical Journal 114 1 49 56 doi 10 1042 bj1140049 PMC 1184794 PMID 4309307 Minson Anthony Charles 1968 Studies of the biosynthesis of histidine in Neurospora crassa PhD thesis Australian National University a b Darby G Minson A C 1973 The Structure of Tobacco Rattle Virus Ribonucleic Acids Common Nucleotide Sequences in the RNA Species Journal of General Virology 21 2 285 295 doi 10 1099 0022 1317 21 2 285 a b Browne H Smith G Beck S Minson T 1990 A complex between the MHC class I homologue encoded by human cytomegalovirus and b2 microglobulin Nature 347 6295 770 772 Bibcode 1990Natur 347 770B doi 10 1038 347770a0 PMID 2172831 S2CID 4249803 rae2008 UOA 3 Infection and Immunology University of Cambridge RA5a Research environment and esteem accessed 14 January 2013 Herpes simplex virus Research HSV Replication Archived 2012 12 12 at archive today accessed 9 January 2013 University of Cambridge Department of Pathology Professor Tony Minson amp Dr Helena Browne Archived 2009 02 21 at the Wayback Machine accessed 10 January 2013 Stanley M A Browne H M Appleby M Minson A C 1989 Properties of a non tumorigenic human cervical keratinocyte cell line International Journal of Cancer 43 4 672 676 doi 10 1002 ijc 2910430422 PMID 2467886 S2CID 25064033 Shoulder A Darby G Minson T 1974 RNA RNA hybridisation using 125I labelled RNA from tobacco necrosis virus and its satellite Nature 251 5477 733 735 Bibcode 1974Natur 251 733S doi 10 1038 251733a0 PMID 4427674 S2CID 4288038 Bell S Cranage M Borysiewicz L Minson T 1990 Induction of immunoglobulin G Fc receptors by recombinant vaccinia viruses expressing glycoproteins E and I of herpes simplex virus type 1 Journal of Virology 64 5 2181 2186 doi 10 1128 JVI 64 5 2181 2186 1990 PMC 249377 PMID 2157879 Cranage M P Kouzarides T Bankier A T Satchwell S Weston K Tomlinson P Barrell B Hart H Bell S E Minson A C 1986 Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus The EMBO Journal 5 11 3057 3063 doi 10 1002 j 1460 2075 1986 tb04606 x PMC 1167261 PMID 3024973 a b Stanberry LR Understanding Herpes A Concise Overview of Recent Advances and New Resources p 98 2nd edn University Press of Mississippi 2006 Googlebooks a b c d Koelle D M Corey L 2003 Recent progress in herpes simplex virus immunobiology and vaccine research Clinical Microbiology Reviews 16 1 96 113 doi 10 1128 CMR 16 1 96 113 2003 PMC 145296 PMID 12525427 a b c d Dudek T Knipe D M 2006 Replication defective viruses as vaccines and vaccine vectors Virology 344 1 230 239 doi 10 1016 j virol 2005 09 020 PMID 16364753 Gregoriadis G McCormack B Allison AC eds Vaccine Design The Role of Cytokine Networks pp 120 122 Plenum Press 1997 ISBN 0306458187 a b c WHO Sexually Transmitted Diseases Herpes simplex type 2 accessed 10 January 2013 Whitley R J Roizman B 2002 Herpes simplex viruses Is a vaccine tenable Journal of Clinical Investigation 110 2 145 151 doi 10 1172 JCI16126 PMC 151069 PMID 12122103 Gross G Tyring SK eds Sexually Transmitted Infections and Sexually Transmitted Diseases p 698 Springer 2011 ISBN 978 3 642 14662 6 Matsuo E Celma C C P Boyce M Viarouge C Sailleau C Dubois E Breard E Thiery R Zientara S Roy P 2011 Generation of Replication Defective Virus Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus Challenge Journal of Virology 85 19 10213 10221 doi 10 1128 JVI 05412 11 PMC 3196398 PMID 21795358 Gomme E A Faul E J Flomenberg P McGettigan J P Schnell M J 2010 Characterization of a Single Cycle Rabies Virus Based Vaccine Vector Journal of Virology 84 6 2820 2831 doi 10 1128 JVI 01870 09 PMC 2826042 PMID 20053743 Cooper M A Dultsev F N Minson T Ostanin V P Abell C Klenerman D 2001 Direct and sensitive detection of a human virus by rupture event scanning Nature Biotechnology 19 9 833 837 doi 10 1038 nbt0901 833 PMID 11533641 S2CID 7307876 Anon 2001 Direct and sensitive detection of a human virus by rupture event scanning researchers hope to hear HIV hepatitis and flu Nature doi 10 1038 news010906 1 Vargas L Recycled Cambridge biosensor technology attracts millions in investment Business Weekly 27 August 2008 accessed 9 January 2013 Roizmann B Desrosiers R C Fleckenstein B Lopez C Minson A C Studdert M J 1992 The familyHerpesviridae An update Archives of Virology 123 3 4 425 449 doi 10 1007 BF01317276 PMID 1562239 a b Davison A J Eberle R Ehlers B Hayward G S McGeoch D J Minson A C Pellett P E Roizman B Studdert M J Thiry E 2008 The order Herpesvirales Archives of Virology 154 1 171 177 doi 10 1007 s00705 008 0278 4 PMC 3552636 PMID 19066710 a b The Reporter Office of Pro Vice Chancellor Planning and Resources Notice accessed 9 January 2013 a b Guardian Cambridge appoints new pro vice chancellor accessed 9 January 2013 Times Higher Education In the news Tony Minson accessed 9 January 2013 Anon 2004 A defeat for primate research Nature Neuroscience 7 5 413 doi 10 1038 nn0504 413 PMID 15114345 Guardian Cambridge abandons plans for primate lab accessed 9 January 2013 Cambridge University Development Office While the 800th Anniversary Campaign has been completed Cambridge s fundraising continues accessed 10 January 2013 Cambridge Infectious Disease About Cambridge Infectious Disease Archived from the original on February 28 2009 Retrieved 2009 01 05 a href Template Cite web html title Template Cite web cite web a CS1 maint bot original URL status unknown link accessed 9 January 2013 Cambridge Infectious Diseases About Us accessed 10 January 2013 Cambridge University Press Annual Report for the year ended 30 April 2012 permanent dead link accessed 7 January 2013 a b Society for General Microbiology Membership Honorary Archived 2012 09 05 at the Wayback Machine accessed 9 January 2013 Journal of General Virology JGV Editors 2012 Archived 2013 04 15 at archive today accessed 9 January 2013 Open Corporates The Pirbright Institute accessed 9 January 2013 The Lister Institute of Preventive Medicine Organisation Archived 2012 12 14 at the Wayback Machine accessed 7 January 2013 Animal Health Trust Frequently Asked Questions accessed 8 January 2013 Minson T 2004 Comment Codes of practice in research Microbiol Today 31 156 pdf permanent dead link Academy of Medical Sciences Fellows accessed 5 January 2009 External links editUniversity of Cambridge Department of Pathology Professor Tony Minson amp Dr Helena Browne Retrieved from https en wikipedia org w index php title Tony Minson amp oldid 1185693929, wikipedia, wiki, book, books, library,

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