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Timothy J. Richmond

April 14, 2024

Timothy John Richmond (born October 9, 1948, in Corvallis) is a Swiss/American molecular biologist, biochemist, and biophysicist.

He graduated in 1970 with a bachelor's degree[1] in biochemistry from Purdue University, where his teachers included Larry G. Butler (died 1997) and Michael G. Rossmann. Richmond graduated in 1975 from Yale University's department of molecular biophysics and biochemistry with a dissertation on protein-DNA interaction under the supervision of Frederic M. Richards and Thomas A. Steitz. Richmond was a postdoc at Yale University from 1975 to 1978 under the supervision of Frederic M. Richards and from 1978 to 1980 at the MRC Laboratory of Molecular Biology under the supervision of Sir Aaron Klug studying the nucleosome (which is the fundamental subunit of chromatin).[2] Richmond was from 1980 to 1987 a tenured staff scientist at the MRC Laboratory of Molecular Biology[1] and in 1987 was appointed "Professor of X-ray Crystallography of Biological Macromolecules"[2] at ETH Zurich's Institute for Molecular Biology and Biophysics.[1] At ETH Zurich he became in 2005 vice-chair of the biology department.[2]

Richmond’s work provides a basis for integrating decades of biochemical, physical, and genetic studies of chromatin. His focus has been to establish the atomic structures of large macromolecular assemblies, particularly those involved in protein-DNA complexes and to relate these structures to the biological processes of chromatin assembly and transcription regulation.[3]

The interests of Prof. Richmond in teaching and research are primarily devoted to the recognition and assembly of biological macromolecular complexes. X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are employed by his laboratory. The focus of his research is on the organization of DNA in chromosomes and the regulation of gene expression in higher organisms. His laboratory has elucidated the structures of the nucleosome core particle and various transcription factor complexes. Their work on the nucleosome core particle, the fundamental repeating unit of chromatin, resulted ultimately in its atomic description at 1.9 å resolution. They have since determined the organization of nucleosomes in the chromatin fiber. [4]

He was the postdoctoral supervisor of Karolin Luger.[5]

Richmond was elected in 1994 a fellow of the American Association for the Advancement of Science (AAAS).[6] He was elected a member in 1995 of the European Molecular Biology Organization (EMBO),[7] in 2000 of the Academia Europaea,[1] in 2004 of the German National Academy of Sciences Leopoldina,[2] and in 2007 of the U.S. National Academy of Sciences.[8] In 2001 he was awarded an honorary doctor of science degree by Purdue University.[9] His prizes or awards include the Louis-Jeantet Prize for Medicine in 2002[10] and the Marcel Benoist Prize in 2006.[11] In 2023, Timothy J. Richmond, Daniela Rhodes and Karolin Luger were awarded the WLA Prize in Life Science or Medicine "for elucidating the structure of the nucleosome at the atomic level, providing the basis for understanding chromatin, gene regulation, and epigenetics."[12]

Selected publications edit

  • Richmond, T. J.; Finch, J. T.; Rushton, B.; Rhodes, D.; Klug, A. (1984). "Structure of the nucleosome core particle at 7 Å resolution". Nature. 311 (5986): 532–537. Bibcode:1984Natur.311..532R. doi:10.1038/311532a0. PMID 6482966. S2CID 4355982. (over 1250 citations)
  • Richmond, Timothy J. (1984). "Solvent accessible surface area and excluded volume in proteins". Journal of Molecular Biology. 178 (1): 63–89. doi:10.1016/0022-2836(84)90231-6. PMID 6548264.
  • Pellegrini, Luca; Tan, Song; Richmond, Timothy J. (1995). "Structure of serum response factor core bound to DNA". Nature. 376 (6540): 490–498. Bibcode:1995Natur.376..490P. doi:10.1038/376490a0. PMID 7637780. S2CID 4338634.
  • Luger, Karolin; Mäder, Armin W.; Richmond, Robin K.; Sargent, David F.; Richmond, Timothy J. (1997). "Crystal structure of the nucleosome core particle at 2.8 Å resolution". Nature. 389 (6648): 251–260. Bibcode:1997Natur.389..251L. doi:10.1038/38444. PMID 9305837. S2CID 4328827. (over 10300 citations)
  • Luger, Karolin; Rechsteiner, Thomas J.; Flaus, Andrew J.; Waye, Mary M.Y; Richmond, Timothy J. (1997). "Characterization of nucleosome core particles containing histone proteins made in bacteria 1 1Edited by A. Klug". Journal of Molecular Biology. 272 (3): 301–311. doi:10.1006/jmbi.1997.1235. PMID 9325091.
  • Luger, Karolin; Richmond, Timothy J. (1998). "The histone tails of the nucleosome". Current Opinion in Genetics & Development. 8 (2): 140–146. doi:10.1016/S0959-437X(98)80134-2. PMID 9610403.
  • Luger, Karolin; Richmond, Timothy J. (1998). "DNA binding within the nucleosome core". Current Opinion in Structural Biology. 8 (1): 33–40. doi:10.1016/S0959-440X(98)80007-9. PMID 9519294.
  • Luger, Karolin; Rechsteiner, Thomas J.; Richmond, Timothy J. (1999). "Preparation of nucleosome core particle from recombinant histones". Chromatin. Methods in Enzymology. Vol. 304. pp. 3–19. doi:10.1016/S0076-6879(99)04003-3. ISBN 9780121822057. PMID 10372352.
  • Luger, Karolin; Rechsteiner, Thomas J.; Richmond, Timothy J. (1999). "Expression and Purification of Recombinant Histones and Nucleosome Reconstitution". Chromatin Protocols. Methods in Molecular Biology. Vol. 119. pp. 1–16. doi:10.1385/1-59259-681-9:1. ISBN 1-59259-681-9. PMID 10804500.
  • Davey, Curt A.; Sargent, David F.; Luger, Karolin; Maeder, Armin W.; Richmond, Timothy J. (2002). "Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9Å Resolution". Journal of Molecular Biology. 319 (5): 1097–1113. doi:10.1016/S0022-2836(02)00386-8. PMID 12079350. (over 1600 citations)
  • Richmond, Timothy J.; Davey, Curt A. (2003). "The structure of DNA in the nucleosome core". Nature. 423 (6936): 145–150. Bibcode:2003Natur.423..145R. doi:10.1038/nature01595. PMID 12736678. S2CID 205209705. 2003 (over 1450 citations)
  • Dorigo, Benedetta; Schalch, Thomas; Bystricky, Kerstin; Richmond, Timothy J. (2003). "Chromatin Fiber Folding: Requirement for the Histone H4 N-terminal Tail". Journal of Molecular Biology. 327 (1): 85–96. doi:10.1016/S0022-2836(03)00025-1. PMID 12614610.
  • Dorigo, Benedetta; Schalch, Thomas; Kulangara, Alexandra; Duda, Sylwia; Schroeder, Rasmus R.; Richmond, Timothy J. (2004). "Nucleosome Arrays Reveal the Two-Start Organization of the Chromatin Fiber". Science. 306 (5701): 1571–1573. Bibcode:2004Sci...306.1571D. doi:10.1126/science.1103124. PMID 15567867. S2CID 20869252.
  • Berger, Imre; Fitzgerald, Daniel J.; Richmond, Timothy J. (2004). "Baculovirus expression system for heterologous multiprotein complexes". Nature Biotechnology. 22 (12): 1583–1587. doi:10.1038/nbt1036. PMID 15568020. S2CID 8834637.
  • Schalch, Thomas; Duda, Sylwia; Sargent, David F.; Richmond, Timothy J. (2005). "X-ray structure of a tetranucleosome and its implications for the chromatin fibre". Nature. 436 (7047): 138–141. Bibcode:2005Natur.436..138S. doi:10.1038/nature03686. PMID 16001076. S2CID 4387396. (over 900 citations)

References edit

  1. ^ a b c d "Timothy J. Richmond (membership number 2024)". Academia Europaea.
  2. ^ a b c d "Neue Mitglieder der Leopoldina 2004" (PDF). Deutsche Akademie der Naturforscher Leopoldina. p. 70.
  3. ^ "2010 Bios". Yale Graduate School of Arts and Sciences.
  4. ^ "Richmond, Timothy J., Prof. Dr". ETH Zürich.
  5. ^ "Timothy J. Richmond, Ph.D." Chemistry Tree (academictree.org).
  6. ^ "Historic Fellows". American Association for the Advancement of Science (aaas.org).
  7. ^ "EMBO Member Timothy J. Richmond". EMBO.
  8. ^ "Member Directory: Timothy J. Richmond". National Academy of Sciences.
  9. ^ "Timothy Richmond". Purdue to award 15 honorary doctorates, Purdue News. April 2001.
  10. ^ "Professor Timothy J. Richmond, Winner of the 2002 Louis-Jeantet Prize for medicine". Fondation Louis-Jeantet. October 2017.
  11. ^ "Laureates". Marcel Benoist Foundation.
  12. ^ Laureates of the 2023 WLA Prize Announced, The WLA Prize

April 14, 2024
timothy, richmond, timothy, john, richmond, born, october, 1948, corvallis, swiss, american, molecular, biologist, biochemist, biophysicist, graduated, 1970, with, bachelor, degree, biochemistry, from, purdue, university, where, teachers, included, larry, butl. Timothy John Richmond born October 9 1948 in Corvallis is a Swiss American molecular biologist biochemist and biophysicist He graduated in 1970 with a bachelor s degree 1 in biochemistry from Purdue University where his teachers included Larry G Butler died 1997 and Michael G Rossmann Richmond graduated in 1975 from Yale University s department of molecular biophysics and biochemistry with a dissertation on protein DNA interaction under the supervision of Frederic M Richards and Thomas A Steitz Richmond was a postdoc at Yale University from 1975 to 1978 under the supervision of Frederic M Richards and from 1978 to 1980 at the MRC Laboratory of Molecular Biology under the supervision of Sir Aaron Klug studying the nucleosome which is the fundamental subunit of chromatin 2 Richmond was from 1980 to 1987 a tenured staff scientist at the MRC Laboratory of Molecular Biology 1 and in 1987 was appointed Professor of X ray Crystallography of Biological Macromolecules 2 at ETH Zurich s Institute for Molecular Biology and Biophysics 1 At ETH Zurich he became in 2005 vice chair of the biology department 2 Richmond s work provides a basis for integrating decades of biochemical physical and genetic studies of chromatin His focus has been to establish the atomic structures of large macromolecular assemblies particularly those involved in protein DNA complexes and to relate these structures to the biological processes of chromatin assembly and transcription regulation 3 The interests of Prof Richmond in teaching and research are primarily devoted to the recognition and assembly of biological macromolecular complexes X ray crystallography cryo electron microscopy and other biophysical and biochemical techniques are employed by his laboratory The focus of his research is on the organization of DNA in chromosomes and the regulation of gene expression in higher organisms His laboratory has elucidated the structures of the nucleosome core particle and various transcription factor complexes Their work on the nucleosome core particle the fundamental repeating unit of chromatin resulted ultimately in its atomic description at 1 9 a resolution They have since determined the organization of nucleosomes in the chromatin fiber 4 He was the postdoctoral supervisor of Karolin Luger 5 Richmond was elected in 1994 a fellow of the American Association for the Advancement of Science AAAS 6 He was elected a member in 1995 of the European Molecular Biology Organization EMBO 7 in 2000 of the Academia Europaea 1 in 2004 of the German National Academy of Sciences Leopoldina 2 and in 2007 of the U S National Academy of Sciences 8 In 2001 he was awarded an honorary doctor of science degree by Purdue University 9 His prizes or awards include the Louis Jeantet Prize for Medicine in 2002 10 and the Marcel Benoist Prize in 2006 11 In 2023 Timothy J Richmond Daniela Rhodes and Karolin Luger were awarded the WLA Prize in Life Science or Medicine for elucidating the structure of the nucleosome at the atomic level providing the basis for understanding chromatin gene regulation and epigenetics 12 Selected publications editRichmond T J Finch J T Rushton B Rhodes D Klug A 1984 Structure of the nucleosome core particle at 7 A resolution Nature 311 5986 532 537 Bibcode 1984Natur 311 532R doi 10 1038 311532a0 PMID 6482966 S2CID 4355982 over 1250 citations Richmond Timothy J 1984 Solvent accessible surface area and excluded volume in proteins Journal of Molecular Biology 178 1 63 89 doi 10 1016 0022 2836 84 90231 6 PMID 6548264 Pellegrini Luca Tan Song Richmond Timothy J 1995 Structure of serum response factor core bound to DNA Nature 376 6540 490 498 Bibcode 1995Natur 376 490P doi 10 1038 376490a0 PMID 7637780 S2CID 4338634 Luger Karolin Mader Armin W Richmond Robin K Sargent David F Richmond Timothy J 1997 Crystal structure of the nucleosome core particle at 2 8 A resolution Nature 389 6648 251 260 Bibcode 1997Natur 389 251L doi 10 1038 38444 PMID 9305837 S2CID 4328827 over 10300 citations Luger Karolin Rechsteiner Thomas J Flaus Andrew J Waye Mary M Y Richmond Timothy J 1997 Characterization of nucleosome core particles containing histone proteins made in bacteria 1 1Edited by A Klug Journal of Molecular Biology 272 3 301 311 doi 10 1006 jmbi 1997 1235 PMID 9325091 Luger Karolin Richmond Timothy J 1998 The histone tails of the nucleosome Current Opinion in Genetics amp Development 8 2 140 146 doi 10 1016 S0959 437X 98 80134 2 PMID 9610403 Luger Karolin Richmond Timothy J 1998 DNA binding within the nucleosome core Current Opinion in Structural Biology 8 1 33 40 doi 10 1016 S0959 440X 98 80007 9 PMID 9519294 Luger Karolin Rechsteiner Thomas J Richmond Timothy J 1999 Preparation of nucleosome core particle from recombinant histones Chromatin Methods in Enzymology Vol 304 pp 3 19 doi 10 1016 S0076 6879 99 04003 3 ISBN 9780121822057 PMID 10372352 Luger Karolin Rechsteiner Thomas J Richmond Timothy J 1999 Expression and Purification of Recombinant Histones and Nucleosome Reconstitution Chromatin Protocols Methods in Molecular Biology Vol 119 pp 1 16 doi 10 1385 1 59259 681 9 1 ISBN 1 59259 681 9 PMID 10804500 Davey Curt A Sargent David F Luger Karolin Maeder Armin W Richmond Timothy J 2002 Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1 9A Resolution Journal of Molecular Biology 319 5 1097 1113 doi 10 1016 S0022 2836 02 00386 8 PMID 12079350 over 1600 citations Richmond Timothy J Davey Curt A 2003 The structure of DNA in the nucleosome core Nature 423 6936 145 150 Bibcode 2003Natur 423 145R doi 10 1038 nature01595 PMID 12736678 S2CID 205209705 2003 over 1450 citations Dorigo Benedetta Schalch Thomas Bystricky Kerstin Richmond Timothy J 2003 Chromatin Fiber Folding Requirement for the Histone H4 N terminal Tail Journal of Molecular Biology 327 1 85 96 doi 10 1016 S0022 2836 03 00025 1 PMID 12614610 Dorigo Benedetta Schalch Thomas Kulangara Alexandra Duda Sylwia Schroeder Rasmus R Richmond Timothy J 2004 Nucleosome Arrays Reveal the Two Start Organization of the Chromatin Fiber Science 306 5701 1571 1573 Bibcode 2004Sci 306 1571D doi 10 1126 science 1103124 PMID 15567867 S2CID 20869252 Berger Imre Fitzgerald Daniel J Richmond Timothy J 2004 Baculovirus expression system for heterologous multiprotein complexes Nature Biotechnology 22 12 1583 1587 doi 10 1038 nbt1036 PMID 15568020 S2CID 8834637 Schalch Thomas Duda Sylwia Sargent David F Richmond Timothy J 2005 X ray structure of a tetranucleosome and its implications for the chromatin fibre Nature 436 7047 138 141 Bibcode 2005Natur 436 138S doi 10 1038 nature03686 PMID 16001076 S2CID 4387396 over 900 citations References edit a b c d Timothy J Richmond membership number 2024 Academia Europaea a b c d Neue Mitglieder der Leopoldina 2004 PDF Deutsche Akademie der Naturforscher Leopoldina p 70 2010 Bios Yale Graduate School of Arts and Sciences Richmond Timothy J Prof Dr ETH Zurich Timothy J Richmond Ph D Chemistry Tree academictree org Historic Fellows American Association for the Advancement of Science aaas org EMBO Member Timothy J Richmond EMBO Member Directory Timothy J Richmond National Academy of Sciences Timothy Richmond Purdue to award 15 honorary doctorates Purdue News April 2001 Professor Timothy J Richmond Winner of the 2002 Louis Jeantet Prize for medicine Fondation Louis Jeantet October 2017 Laureates Marcel Benoist Foundation Laureates of the 2023 WLA Prize Announced The WLA Prize Retrieved from https en wikipedia org w index php title Timothy J Richmond amp oldid 1187810993, wikipedia, wiki, book, books, library,

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