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Property of a material (or substance) that induces and/or promotes the formation of a thrombus.[1]
Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed thrombi but also to emboli, thrombi which have become detached and travel through the bloodstream. Thrombogenicity can also encompass events such as the activation of immune pathways and the complement system. All materials are considered to be thrombogenic[citation needed] with the exception of the normal state of endothelial cells which line blood vessels.[2] Certain medical implants appear non-thrombogenic due to high flow rates of blood past the implant, but in reality all are thrombogenic to a degree. Various surface treatments are available to minimize these thrombogenic effects.
A thrombogenic implant will eventually be covered by a fibrous capsule, the thickness of this capsule can be considered one measure of thrombogenicity, and if extreme can lead to the failure of the implant.
thrombogenicity, this, article, needs, more, reliable, medical, references, verification, relies, heavily, primary, sources, please, review, contents, article, appropriate, references, unsourced, poorly, sourced, material, challenged, removed, find, sources, n. This article needs more reliable medical references for verification or relies too heavily on primary sources Please review the contents of the article and add the appropriate references if you can Unsourced or poorly sourced material may be challenged and removed Find sources Thrombogenicity news newspapers books scholar JSTOR November 2021 IUPAC definition Property of a material or substance that induces and or promotesthe formation of a thrombus 1 Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus or clot It not only refers to fixed thrombi but also to emboli thrombi which have become detached and travel through the bloodstream Thrombogenicity can also encompass events such as the activation of immune pathways and the complement system All materials are considered to be thrombogenic citation needed with the exception of the normal state of endothelial cells which line blood vessels 2 Certain medical implants appear non thrombogenic due to high flow rates of blood past the implant but in reality all are thrombogenic to a degree Various surface treatments are available to minimize these thrombogenic effects A thrombogenic implant will eventually be covered by a fibrous capsule the thickness of this capsule can be considered one measure of thrombogenicity and if extreme can lead to the failure of the implant See also editEndothelial activationReferences edit Vert Michel Doi Yoshiharu Hellwich Karl Heinz Hess Michael Hodge Philip Kubisa Przemyslaw Rinaudo Marguerite Schue Francois 2012 Terminology for biorelated polymers and applications IUPAC Recommendations 2012 PDF Pure and Applied Chemistry 84 2 377 410 doi 10 1351 PAC REC 10 12 04 S2CID 98107080 Lopez JA Chen J 2009 Pathophysiology of venous thrombosis Thromb Res 123 Suppl 4 S30 4 doi 10 1016 S0049 3848 09 70140 9 PMID 19303501 Further reading editPaul R Marseille O Hintze E Huber L Schima H Reul H Rau G 1998 In vitro thrombogenicity testing of artificial organs The International Journal of Artificial Organs 21 9 548 52 doi 10 1177 039139889802100910 PMID 9828061 S2CID 21180052 Kenny DA Berger K Walker MW Robel SB Boguslavsky L Ray LI Lischko MM Sauvage LR 1980 Experimental comparison of the thrombogenicity of fibrin and PTFE flow surfaces Annals of Surgery 191 3 355 61 doi 10 1097 00000658 198003000 00016 PMC 1344708 PMID 6444800 nbsp This hematology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Thrombogenicity amp oldid 1055207946, wikipedia, wiki, book, books, library,
