Tc-99m tetrofosmin is rapidly taken up by myocardial tissue and reaches its maximum level in approximately 5 minutes. About 66% of the total injected dose is excreted within 48 hours after injection (40% urine, 26% feces). Tc-99m tetrofosmin is indicated for use in scintigraphic imaging of the myocardium under stress and rest conditions. It is used to determine areas of reversible ischemia and infarcted tissue in the heart. It is also indicated to detect changes in perfusion induced by pharmacologic stress (adenosine, lexiscan, dobutamine or persantine) in patients with coronary artery disease. Its third indication is to assess left ventricular function (ejection fraction) in patients thought to have heart disease. No contraindications are known for use of Tc-99m tetrofosmin, but care should be taken to constantly monitor the cardiac function in patients with known or suspected coronary artery disease. Patients should be encouraged to void their bladders as soon as the images are gathered, and as often as possible after the tests to decrease their radiation doses, since the majority of elimination is renal. The recommended dose of Tc-99m tetrofosmin is between 5 and 33 millicuries (185-1221 megabecquerels). For a two-dose stress/rest dosing, the typical dose is normally a 10 mCi dose, followed one to four hours later by a dose of 30 mCi. Imaging normally begins 15 minutes following injection.[3]
Referencesedit
^Kelly JD, Forster AM, Higley B, Archer CM, Booker FS, Canning LR, et al. (February 1993). "Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging". Journal of Nuclear Medicine. 34 (2): 222–227. PMID 8429340.
^Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Huurman A, et al. (December 2005). "Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging". Journal of Nuclear Medicine. 46 (12): 2003–2008. PMID 16330563.
^"Myoview package insert" (PDF). Arlington Heights, IL: GE Healthcare. August 2006.
External linksedit
Myoview Prescribing Information Page
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technetium, 99mtc, tetrofosmin, drug, used, nuclear, medicine, cardiac, imaging, sold, under, brand, name, myoview, healthcare, radioisotope, technetium, chelated, ethoxyethyl, phosphino, ethane, ligands, which, belong, group, diphosphines, which, referred, te. Technetium 99mTc tetrofosmin is a drug used in nuclear medicine cardiac imaging It is sold under the brand name Myoview GE Healthcare The radioisotope technetium 99m is chelated by two 1 2 bis di 2 ethoxyethyl phosphino ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin 1 2 Technetium 99mTc tetrofosminClinical dataRoutes ofadministrationIntravenousATC codeV09GA02 WHO Pharmacokinetic dataBioavailabilityN AIdentifiersCAS Number127455 27 0 Y 127502 06 1 tetrofosmin UNII42FOP1YX93CompTox Dashboard EPA DTXSID70155576Chemical and physical dataFormulaC 36H 80O 10P 4TcMolar mass895 g mol 1 verify Tc 99m tetrofosmin is rapidly taken up by myocardial tissue and reaches its maximum level in approximately 5 minutes About 66 of the total injected dose is excreted within 48 hours after injection 40 urine 26 feces Tc 99m tetrofosmin is indicated for use in scintigraphic imaging of the myocardium under stress and rest conditions It is used to determine areas of reversible ischemia and infarcted tissue in the heart It is also indicated to detect changes in perfusion induced by pharmacologic stress adenosine lexiscan dobutamine or persantine in patients with coronary artery disease Its third indication is to assess left ventricular function ejection fraction in patients thought to have heart disease No contraindications are known for use of Tc 99m tetrofosmin but care should be taken to constantly monitor the cardiac function in patients with known or suspected coronary artery disease Patients should be encouraged to void their bladders as soon as the images are gathered and as often as possible after the tests to decrease their radiation doses since the majority of elimination is renal The recommended dose of Tc 99m tetrofosmin is between 5 and 33 millicuries 185 1221 megabecquerels For a two dose stress rest dosing the typical dose is normally a 10 mCi dose followed one to four hours later by a dose of 30 mCi Imaging normally begins 15 minutes following injection 3 References edit Kelly JD Forster AM Higley B Archer CM Booker FS Canning LR et al February 1993 Technetium 99m tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging Journal of Nuclear Medicine 34 2 222 227 PMID 8429340 Elhendy A Schinkel AF van Domburg RT Bax JJ Valkema R Huurman A et al December 2005 Risk stratification of patients with angina pectoris by stress 99mTc tetrofosmin myocardial perfusion imaging Journal of Nuclear Medicine 46 12 2003 2008 PMID 16330563 Myoview package insert PDF Arlington Heights IL GE Healthcare August 2006 External links editMyoview Prescribing Information Page nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Technetium 99mTc tetrofosmin amp oldid 1185097349, wikipedia, wiki, book, books, library,
