In molecular biology, TUG-UBL1 refers to a protein that regulates a glucose transporter called GLUT4. TUG-UBL1 is an acronym for Tether containing UBX domain for GLUT4-Ubiquitin Like 1, this is encoded for by the gene, ASPSCR1.
TUG
solution structure and backbone dynamics of an n-terminal ubiquitin-like domain in the glut4-tethering protein, tug
When insulin is secreted, glucose uptake of cells increase, since insulin stimulates GLUT4 to move from the intracellular surface to the outer surface. In a similar fashion, TUG retains GLUT4 within unstimulated cells, but when insulin is secreted it causes GLUT4 to dissociate and so GLUT4 moves to the cell surface. TUG binds directly and specifically to a large intracellular loop in GLUT4. It acts as a tethering protein, which along with other proteins, retain GLUT4 within cells in the absence of insulin. Additionally, when the protein TUG becomes disrupted it appears to accelerate the degradation of GLUT4 in lysosomes. However, the functional role of the TUG–UBL1 domain remains to be elucidated.[1]
Structureedit
N-terminalubiquitin-like domain (TUG–UBL1) has a tertiary structure of TUG–UBL1, which consists of a beta-grasp or ubiquitin-like topology for this domain. This comprises a five-stranded beta-sheet, a single major alpha-helix (residues 32–42), and two short helices.[2]
^Yu C, Cresswell J, Löffler MG, Bogan JS (2007). "The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes". J Biol Chem. 282 (10): 7710–22. doi:10.1074/jbc.M610824200. PMC2243252. PMID 17202135.
^ abcdTettamanzi MC, Yu C, Bogan JS, Hodsdon ME (2006). "Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-regulating protein, TUG". Protein Sci. 15 (3): 498–508. doi:10.1110/ps.051901806. PMC2249771. PMID 16501224.
This article incorporates text from the public domain Pfam and InterPro: IPR021569
April 12, 2024
ubl1, protein, domain, molecular, biology, ubl1, refers, protein, that, regulates, glucose, transporter, called, glut4, ubl1, acronym, tether, containing, domain, glut4, ubiquitin, like, this, encoded, gene, aspscr1, tugsolution, structure, backbone, dynamics,. In molecular biology TUG UBL1 refers to a protein that regulates a glucose transporter called GLUT4 TUG UBL1 is an acronym for Tether containing UBX domain for GLUT4 Ubiquitin Like 1 this is encoded for by the gene ASPSCR1 TUGsolution structure and backbone dynamics of an n terminal ubiquitin like domain in the glut4 tethering protein tugIdentifiersSymbolTUGPfamPF11470Pfam clanCL0072InterProIPR021569Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Function 2 Structure 3 Mechanism 4 ReferencesFunction editWhen insulin is secreted glucose uptake of cells increase since insulin stimulates GLUT4 to move from the intracellular surface to the outer surface In a similar fashion TUG retains GLUT4 within unstimulated cells but when insulin is secreted it causes GLUT4 to dissociate and so GLUT4 moves to the cell surface TUG binds directly and specifically to a large intracellular loop in GLUT4 It acts as a tethering protein which along with other proteins retain GLUT4 within cells in the absence of insulin Additionally when the protein TUG becomes disrupted it appears to accelerate the degradation of GLUT4 in lysosomes However the functional role of the TUG UBL1 domain remains to be elucidated 1 Structure editN terminal ubiquitin like domain TUG UBL1 has a tertiary structure of TUG UBL1 which consists of a beta grasp or ubiquitin like topology for this domain This comprises a five stranded beta sheet a single major alpha helix residues 32 42 and two short helices 2 Mechanism editTUG releases the GLUT4 containing vesicles GSVs in response to insulin stimulation which allows it to move to the plasma membrane 2 TUG has an N terminal ubiquitin like protein domain UBL1 which in similar proteins appears to participate in protein protein interactions 2 The region does have an area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein protein interaction site 2 References edit Yu C Cresswell J Loffler MG Bogan JS 2007 The glucose transporter 4 regulating protein TUG is essential for highly insulin responsive glucose uptake in 3T3 L1 adipocytes J Biol Chem 282 10 7710 22 doi 10 1074 jbc M610824200 PMC 2243252 PMID 17202135 a b c d Tettamanzi MC Yu C Bogan JS Hodsdon ME 2006 Solution structure and backbone dynamics of an N terminal ubiquitin like domain in the GLUT4 regulating protein TUG Protein Sci 15 3 498 508 doi 10 1110 ps 051901806 PMC 2249771 PMID 16501224 This article incorporates text from the public domain Pfam and InterPro IPR021569 Retrieved from https en wikipedia org w index php title TUG UBL1 protein domain amp oldid 1095346049, wikipedia, wiki, book, books, library,
