Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. Alternative splicing has been observed for this gene and two variants have been identified.[4]
^Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (Feb 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". The Journal of Neuroscience. 22 (3): 698–707. doi:10.1523/JNEUROSCI.22-03-00698.2002. PMC6758498. PMID 11826099.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
External linksedit
Human TUBA3C genome location and TUBA3C gene details page in the UCSC Genome Browser.
Further readingedit
Desai A, Mitchison TJ (Jul 1998). "Tubulin and FtsZ structures: functional and therapeutic implications". BioEssays. 20 (7): 523–7. doi:10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L. PMID 9722999.
Oakley BR (Dec 2000). "An abundance of tubulins". Trends in Cell Biology. 10 (12): 537–42. doi:10.1016/S0962-8924(00)01857-2. PMID 11121746.
Dutcher SK (Feb 2001). "The tubulin fraternity: alpha to eta". Current Opinion in Cell Biology. 13 (1): 49–54. doi:10.1016/S0955-0674(00)00173-3. PMID 11163133.
Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, Zajac-Kaye M (Sep 1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Molecular and Cellular Biology. 15 (9): 5188–95. doi:10.1128/MCB.15.9.5188. PMC230766. PMID 7651436.
Guilford P, Dodé C, Crozet F, Blanchard S, Chaïb H, Levilliers J, Levi-Acobas F, Weil D, Weissenbach J, Cohen D (Sep 1995). "A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness (DFNB1 and DFNA3) and limb-girdle muscular dystrophy type 2C (LGMD2C)". Genomics. 29 (1): 163–9. doi:10.1006/geno.1995.1227. PMID 8530067.
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B (Dec 1995). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase". European Journal of Immunology. 25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID 8566014. S2CID 37614803.
Crépieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J (Dec 1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain". Molecular and Cellular Biology. 17 (12): 7375–85. doi:10.1128/MCB.17.12.7375. PMC232593. PMID 9372968.
Kibar Z, Lafrenière RG, Chakravarti A, Wang JC, Chevrette M, Der Kaloustian VM, Rouleau GA (Feb 1999). "A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q". Genomics. 56 (1): 127–30. doi:10.1006/geno.1998.5698. PMID 10036193.
Herreros L, Rodríguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F, Longo N, Turner CE, Sánchez-Mateos P (Aug 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". The Journal of Biological Chemistry. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. hdl:10261/135387. PMID 10840040.
Watts NR, Sackett DL, Ward RD, Miller MW, Wingfield PT, Stahl SS, Steven AC (Jul 2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". The Journal of Cell Biology. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC2180222. PMID 10908577.
Takeoka A, Shimizu M, Horio T (Dec 2000). "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction". Journal of Cell Science. 113 (24): 4557–62. doi:10.1242/jcs.113.24.4557. PMID 11082048.
Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (Dec 2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551. S2CID 41279377.
Kourmouli N, Dialynas G, Petraki C, Pyrpasopoulou A, Singh PB, Georgatos SD, Theodoropoulos PA (Apr 2001). "Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin". The Journal of Biological Chemistry. 276 (16): 13007–14. doi:10.1074/jbc.M007135200. PMID 11278332.
Rommelaere H, De Neve M, Neirynck K, Peelaers D, Waterschoot D, Goethals M, Fraeyman N, Vandekerckhove J, Ampe C (Nov 2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". The Journal of Biological Chemistry. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (Feb 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". The Journal of Neuroscience. 22 (3): 698–707. doi:10.1523/JNEUROSCI.22-03-00698.2002. PMC6758498. PMID 11826099.
Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (Mar 2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". Journal of Neurochemistry. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC2925652. PMID 11953448.
This protein-related article is a stub. You can help Wikipedia by expanding it.
alpha, tubulin, tubulin, alpha, chain, protein, that, humans, encoded, tuba3c, gene, tuba3cidentifiersaliasestuba3c, tuba2, ba408e5, tubulin, alpha, 3cexternal, idsomim, 602528, homologene, 134742, genecards, tuba3cgene, location, human, chromosome, human, ban. Tubulin alpha 3C D chain is a protein that in humans is encoded by the TUBA3C gene 3 4 TUBA3CIdentifiersAliasesTUBA3C TUBA2 bA408E5 3 Alpha tubulin 3C tubulin alpha 3cExternal IDsOMIM 602528 HomoloGene 134742 GeneCards TUBA3CGene location Human Chr Chromosome 13 human 1 Band13q12 11Start19 173 772 bp 1 End19 181 824 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytespermtriceps brachii muscleponsvena cavasecondary oocytecerebellar vermisright ventricleinternal globus pallidussubthalamic nucleusn aMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding GTP binding structural constituent of cytoskeleton protein binding GTPase activityCellular componentcytoplasm microtubule cytoskeleton nucleus microtubule cytoskeleton cilium ciliary basal bodyBiological processmicrotubule based process cytoskeleton organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez7278n aEnsemblENSG00000198033n aUniProtQ1ZYQ1P0DPH8n aRefSeq mRNA NM 079836NM 006001n aRefSeq protein NP 525125NP 005992n aLocation UCSC Chr 13 19 17 19 18 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Function 2 Interactions 3 References 4 External links 5 Further readingFunction editMicrotubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin The genes encoding these microtubule constituents are part of the tubulin superfamily which is composed of six distinct families Genes from the alpha beta and gamma tubulin families are found in all eukaryotes The alpha and beta tubulins represent the major components of microtubules while gamma tubulin plays a critical role in the nucleation of microtubule assembly There are multiple alpha and beta tubulin genes and they are highly conserved among and between species This gene is an alpha tubulin gene that encodes a protein 99 to the mouse testis specific Tuba3 and Tuba7 gene products This gene is located in the 13q11 region which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome Alternative splicing has been observed for this gene and two variants have been identified 4 Interactions editAlpha tubulin 3C has been shown to interact with FYN 5 and NMI 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000198033 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Dode C Weil D Levilliers J Crozet F Chaib H Levi Acobas F Guilford P Petit C Jan 1998 Sequence characterization of a newly identified human alpha tubulin gene TUBA2 Genomics 47 1 125 30 doi 10 1006 geno 1997 5081 PMID 9465305 a b Entrez Gene TUBA3C tubulin alpha 3c Klein C Kramer EM Cardine AM Schraven B Brandt R Trotter J Feb 2002 Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau The Journal of Neuroscience 22 3 698 707 doi 10 1523 JNEUROSCI 22 03 00698 2002 PMC 6758498 PMID 11826099 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Oct 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editHuman TUBA3C genome location and TUBA3C gene details page in the UCSC Genome Browser Further reading editDesai A Mitchison TJ Jul 1998 Tubulin and FtsZ structures functional and therapeutic implications BioEssays 20 7 523 7 doi 10 1002 SICI 1521 1878 199807 20 7 lt 523 AID BIES1 gt 3 0 CO 2 L PMID 9722999 Oakley BR Dec 2000 An abundance of tubulins Trends in Cell Biology 10 12 537 42 doi 10 1016 S0962 8924 00 01857 2 PMID 11121746 Dutcher SK Feb 2001 The tubulin fraternity alpha to eta Current Opinion in Cell Biology 13 1 49 54 doi 10 1016 S0955 0674 00 00173 3 PMID 11163133 Alexandrova N Niklinski J Bliskovsky V Otterson GA Blake M Kaye FJ Zajac Kaye M Sep 1995 The N terminal domain of c Myc associates with alpha tubulin and microtubules in vivo and in vitro Molecular and Cellular Biology 15 9 5188 95 doi 10 1128 MCB 15 9 5188 PMC 230766 PMID 7651436 Guilford P Dode C Crozet F Blanchard S Chaib H Levilliers J Levi Acobas F Weil D Weissenbach J Cohen D Sep 1995 A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness DFNB1 and DFNA3 and limb girdle muscular dystrophy type 2C LGMD2C Genomics 29 1 163 9 doi 10 1006 geno 1995 1227 PMID 8530067 Marie Cardine A Kirchgessner H Eckerskorn C Meuer SC Schraven B Dec 1995 Human T lymphocyte activation induces tyrosine phosphorylation of alpha tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase European Journal of Immunology 25 12 3290 7 doi 10 1002 eji 1830251214 PMID 8566014 S2CID 37614803 Crepieux P Kwon H Leclerc N Spencer W Richard S Lin R Hiscott J Dec 1997 I kappaB alpha physically interacts with a cytoskeleton associated protein through its signal response domain Molecular and Cellular Biology 17 12 7375 85 doi 10 1128 MCB 17 12 7375 PMC 232593 PMID 9372968 Kibar Z Lafreniere RG Chakravarti A Wang JC Chevrette M Der Kaloustian VM Rouleau GA Feb 1999 A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q Genomics 56 1 127 30 doi 10 1006 geno 1998 5698 PMID 10036193 Herreros L Rodriguez Fernandez JL Brown MC Alonso Lebrero JL Cabanas C Sanchez Madrid F Longo N Turner CE Sanchez Mateos P Aug 2000 Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton The Journal of Biological Chemistry 275 34 26436 40 doi 10 1074 jbc M003970200 hdl 10261 135387 PMID 10840040 Watts NR Sackett DL Ward RD Miller MW Wingfield PT Stahl SS Steven AC Jul 2000 HIV 1 rev depolymerizes microtubules to form stable bilayered rings The Journal of Cell Biology 150 2 349 60 doi 10 1083 jcb 150 2 349 PMC 2180222 PMID 10908577 Takeoka A Shimizu M Horio T Dec 2000 Identification of an alpha tubulin mutant of fission yeast from gamma tubulin interacting protein screening genetic evidence for alpha gamma tubulin interaction Journal of Cell Science 113 24 4557 62 doi 10 1242 jcs 113 24 4557 PMID 11082048 Germani A Bruzzoni Giovanelli H Fellous A Gisselbrecht S Varin Blank N Calvo F Dec 2000 SIAH 1 interacts with alpha tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis Oncogene 19 52 5997 6006 doi 10 1038 sj onc 1204002 PMID 11146551 S2CID 41279377 Kourmouli N Dialynas G Petraki C Pyrpasopoulou A Singh PB Georgatos SD Theodoropoulos PA Apr 2001 Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin The Journal of Biological Chemistry 276 16 13007 14 doi 10 1074 jbc M007135200 PMID 11278332 Rommelaere H De Neve M Neirynck K Peelaers D Waterschoot D Goethals M Fraeyman N Vandekerckhove J Ampe C Nov 2001 Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families The Journal of Biological Chemistry 276 44 41023 8 doi 10 1074 jbc M106591200 PMID 11535601 Klein C Kramer EM Cardine AM Schraven B Brandt R Trotter J Feb 2002 Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau The Journal of Neuroscience 22 3 698 707 doi 10 1523 JNEUROSCI 22 03 00698 2002 PMC 6758498 PMID 11826099 Saugstad JA Yang S Pohl J Hall RA Conn PJ Mar 2002 Interaction between metabotropic glutamate receptor 7 and alpha tubulin Journal of Neurochemistry 80 6 980 8 doi 10 1046 j 0022 3042 2002 00778 x PMC 2925652 PMID 11953448 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Alpha tubulin 3C amp oldid 1198585508, wikipedia, wiki, book, books, library,
