Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.[3][4][5]
Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.
Structureedit
The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[5] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
Functionedit
This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.[5]
^Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J (June 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. 107 (11): 1459–68. doi:10.1172/JCI12159. PMC209323. PMID 11390428.
^ abHsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL (May 2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. doi:10.4049/jimmunol.168.10.4846. PMID 11994433.
Further readingedit
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Bai C, Connolly B, Metzker ML, et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. Bibcode:2000PNAS...97.1230B. doi:10.1073/pnas.97.3.1230. PMC15578. PMID 10655513.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Migone TS, Zhang J, Luo X, et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator". Immunity. 16 (3): 479–92. doi:10.1016/S1074-7613(02)00283-2. PMID 11911831.
Hsu TL, Chang YC, Chen SJ, et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. doi:10.4049/jimmunol.168.10.4846. PMID 11994433.
Mild G, Bachmann F, Boulay JL, et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer". Int. J. Cancer. 102 (3): 254–7. doi:10.1002/ijc.10711. PMID 12397645. S2CID 23680078.
Gill RM; Ni J; Hunt JS (2003). "Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes". Am. J. Pathol. 161 (6): 2011–7. doi:10.1016/S0002-9440(10)64479-3. PMC1850908. PMID 12466117.
Wan X, Zhang J, Luo H, et al. (2003). "A TNF family member LIGHT transduces costimulatory signals into human T cells". J. Immunol. 169 (12): 6813–21. doi:10.4049/jimmunol.169.12.6813. PMID 12471113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Wan X, Shi G, Semenuk M, et al. (2003). "DcR3/TR6 modulates immune cell interactions". J. Cell. Biochem. 89 (3): 603–12. doi:10.1002/jcb.10523. PMID 12761893. S2CID 39322989.
Tsuji S, Hosotani R, Yonehara S, et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma" (PDF). Int. J. Cancer. 106 (1): 17–25. doi:10.1002/ijc.11170. hdl:2433/148465. PMID 12794752. S2CID 34900944.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Shi G; Wu Y; Zhang J; Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo". J. Immunol. 171 (7): 3407–14. doi:10.4049/jimmunol.171.7.3407. PMID 14500635.
Wu SF, Liu TM, Lin YC, et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication". J. Leukoc. Biol. 75 (2): 293–306. doi:10.1189/jlb.0303119. PMID 14634066. S2CID 14226200.
Chang YC, Hsu TL, Lin HH, et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3". J. Leukoc. Biol. 75 (3): 486–94. doi:10.1189/jlb.0903448. PMID 14657214. S2CID 31939119.
Kim S, McAuliffe WJ, Zaritskaya LS, et al. (2004). "Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells". Infect. Immun. 72 (1): 89–93. doi:10.1128/IAI.72.1.89-93.2004. PMC343977. PMID 14688085.
Hsu MJ, Lin WW, Tsao WC, et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3". Exp. Cell Res. 292 (2): 241–51. doi:10.1016/j.yexcr.2003.09.019. PMID 14697332.
Gill RM; Hunt JS (2004). "Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis". Am. J. Pathol. 165 (1): 309–17. doi:10.1016/S0002-9440(10)63298-1. PMC1618528. PMID 15215185.
External linksedit
GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome
decoy, receptor, dcr3, also, known, tumor, necrosis, factor, receptor, superfamily, member, tnfrsf6b, soluble, protein, tumor, necrosis, factor, receptor, superfamily, which, inhibits, ligand, induced, apoptosis, tnfrsf6bavailable, structurespdbhuman, uniprot,. Decoy receptor 3 Dcr3 also known as tumor necrosis factor receptor superfamily member 6B TNFRSF6B TR6 and M68 is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand induced apoptosis 3 4 5 TNFRSF6BAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSVIdentifiersAliasesTNFRSF6B DCR3 DJ583P15 1 1 M68 M68E TR6 tumor necrosis factor receptor superfamily member 6b TNF receptor superfamily member 6bExternal IDsOMIM 603361 HomoloGene 48242 GeneCards TNFRSF6BGene location Human Chr Chromosome 20 human 1 Band20q13 33Start63 696 652 bp 1 End63 698 684 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleensubcutaneous adipose tissueright lungupper lobe of left lungappendixanterior pituitaryamygdalahypothalamusputamenleft uterine tuben aMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding tumor necrosis factor activated receptor activity signaling receptor activityCellular componentextracellular region integral component of plasma membrane extracellular spaceBiological processmulticellular organism development apoptotic signaling pathway response to lipopolysaccharide inflammatory response tumor necrosis factor mediated signaling pathway negative regulation of apoptotic process regulation of cell population proliferation immune response apoptotic process negative regulation of cysteine type endopeptidase activity involved in apoptotic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8771n aEnsemblENSG00000243509n aUniProtO95407n aRefSeq mRNA NM 032945NM 003823n aRefSeq protein NP 003814n aLocation UCSC Chr 20 63 7 63 7 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Discovery 2 Structure 3 Function 4 Interactions 5 References 6 Further reading 7 External linksDiscovery editDcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag EST database Structure editThe open reading frame of TNFRSF6B encodes 300 amino acids with a 29 residue signal sequence and four tandem cystein rich repeats Two transcript variants encoding the same isoform but differing in the 5 UTR have been observed for this gene 5 Unlike most of the other members of TNFR superfamily TNFRSF6 is a soluble protein which contains no transmembrane domain Function editThis gene belongs to the tumor necrosis factor receptor superfamily It acts as a decoy receptor that competes with death receptors for ligand binding The encoded protein is postulated to play a regulatory role in suppressing FasL and LIGHT mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A Overexpression of this gene has been noted in various tumors e g gastrointestinal tract tumors and it is located in a gene rich cluster on chromosome 20 with other potentially tumor related genes 5 Interactions editTNFRSF6B has been shown to interact with TNFSF14 4 6 7 Fas ligand 3 4 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000243509 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Pitti RM Marsters SA Lawrence DA Roy M Kischkel FC Dowd P Huang A Donahue CJ Sherwood SW Baldwin DT Godowski PJ Wood WI Gurney AL Hillan KJ Cohen RL Goddard AD Botstein D Ashkenazi A Jan 1999 Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer Nature 396 6712 699 703 doi 10 1038 25387 PMID 9872321 S2CID 4427455 a b c Yu KY Kwon B Ni J Zhai Y Ebner R Kwon BS Jun 1999 A newly identified member of tumor necrosis factor receptor superfamily TR6 suppresses LIGHT mediated apoptosis J Biol Chem 274 20 13733 6 doi 10 1074 jbc 274 20 13733 PMID 10318773 a b c Entrez Gene TNFRSF6B tumor necrosis factor receptor superfamily member 6b decoy Zhang J Salcedo TW Wan X Ullrich S Hu B Gregorio T Feng P Qi S Chen H Cho YH Li Y Moore PA Wu J June 2001 Modulation of T cell responses to alloantigens by TR6 DcR3 J Clin Invest 107 11 1459 68 doi 10 1172 JCI12159 PMC 209323 PMID 11390428 a b Hsu TL Chang YC Chen SJ Liu YJ Chiu AW Chio CC Chen L Hsieh SL May 2002 Modulation of dendritic cell differentiation and maturation by decoy receptor 3 J Immunol 168 10 4846 53 doi 10 4049 jimmunol 168 10 4846 PMID 11994433 Further reading editKikuno R Nagase T Ishikawa K et al 1999 Prediction of the coding sequences of unidentified human genes XIV The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 6 3 197 205 doi 10 1093 dnares 6 3 197 PMID 10470851 Bai C Connolly B Metzker ML et al 2000 Overexpression of M68 DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four gene cluster Proc Natl Acad Sci U S A 97 3 1230 5 Bibcode 2000PNAS 97 1230B doi 10 1073 pnas 97 3 1230 PMC 15578 PMID 10655513 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Migone TS Zhang J Luo X et al 2002 TL1A is a TNF like ligand for DR3 and TR6 DcR3 and functions as a T cell costimulator Immunity 16 3 479 92 doi 10 1016 S1074 7613 02 00283 2 PMID 11911831 Hsu TL Chang YC Chen SJ et al 2002 Modulation of dendritic cell differentiation and maturation by decoy receptor 3 J Immunol 168 10 4846 53 doi 10 4049 jimmunol 168 10 4846 PMID 11994433 Mild G Bachmann F Boulay JL et al 2002 DCR3 locus is a predictive marker for 5 fluorouracil based adjuvant chemotherapy in colorectal cancer Int J Cancer 102 3 254 7 doi 10 1002 ijc 10711 PMID 12397645 S2CID 23680078 Gill RM Ni J Hunt JS 2003 Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes Am J Pathol 161 6 2011 7 doi 10 1016 S0002 9440 10 64479 3 PMC 1850908 PMID 12466117 Wan X Zhang J Luo H et al 2003 A TNF family member LIGHT transduces costimulatory signals into human T cells J Immunol 169 12 6813 21 doi 10 4049 jimmunol 169 12 6813 PMID 12471113 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Wan X Shi G Semenuk M et al 2003 DcR3 TR6 modulates immune cell interactions J Cell Biochem 89 3 603 12 doi 10 1002 jcb 10523 PMID 12761893 S2CID 39322989 Tsuji S Hosotani R Yonehara S et al 2003 Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma PDF Int J Cancer 106 1 17 25 doi 10 1002 ijc 11170 hdl 2433 148465 PMID 12794752 S2CID 34900944 Clark HF Gurney AL Abaya E et al 2003 The Secreted Protein Discovery Initiative SPDI a Large Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins A Bioinformatics Assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Shi G Wu Y Zhang J Wu J 2004 Death decoy receptor TR6 DcR3 inhibits T cell chemotaxis in vitro and in vivo J Immunol 171 7 3407 14 doi 10 4049 jimmunol 171 7 3407 PMID 14500635 Wu SF Liu TM Lin YC et al 2004 Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow derived dendritic cells in nonobese diabetic mice from regulatory mechanism to clinical implication J Leukoc Biol 75 2 293 306 doi 10 1189 jlb 0303119 PMID 14634066 S2CID 14226200 Chang YC Hsu TL Lin HH et al 2004 Modulation of macrophage differentiation and activation by decoy receptor 3 J Leukoc Biol 75 3 486 94 doi 10 1189 jlb 0903448 PMID 14657214 S2CID 31939119 Kim S McAuliffe WJ Zaritskaya LS et al 2004 Selective Induction of Tumor Necrosis Receptor Factor 6 Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells Infect Immun 72 1 89 93 doi 10 1128 IAI 72 1 89 93 2004 PMC 343977 PMID 14688085 Hsu MJ Lin WW Tsao WC et al 2004 Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3 Exp Cell Res 292 2 241 51 doi 10 1016 j yexcr 2003 09 019 PMID 14697332 Gill RM Hunt JS 2004 Soluble Receptor DcR3 and Cellular Inhibitor of Apoptosis 2 cIAP 2 Protect Human Cytotrophoblast Cells Against LIGHT Mediated Apoptosis Am J Pathol 165 1 309 17 doi 10 1016 S0002 9440 10 63298 1 PMC 1618528 PMID 15215185 External links editGeneReviews NCBI NIH UW entry on Autoimmune Lymphoproliferative SyndromeThis article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Decoy receptor 3 amp oldid 1187551218, wikipedia, wiki, book, books, library,
