Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[4]
^ abMenon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC2265268. PMID 18173839.
^Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (August 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ abOhh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC481054. PMID 10587522.
^Krumm A, Groudine M (September 1995). "Tumor suppression and transcription elongation: the dire consequences of changing partners". Science. 269 (5229): 1400–1. Bibcode:1995Sci...269.1400K. doi:10.1126/science.7660121. PMID 7660121. S2CID 39758696.
^Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (February 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–62. doi:10.1074/jbc.M108269200. PMID 11739384.
^Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
^Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (June 2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science. 296 (5574): 1886–9. Bibcode:2002Sci...296.1886M. doi:10.1126/science.1073440. PMID 12004076. S2CID 19641938.
^Hacker KE, Lee CM, Rathmell WK (2008). Zhang B (ed.). "VHL type 2B mutations retain VBC complex form and function". PLOS ONE. 3 (11): e3801. Bibcode:2008PLoSO...3.3801H. doi:10.1371/journal.pone.0003801. PMC2583047. PMID 19030229.
Aso T, Lane WS, Conaway JW, Conaway RC (1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. Bibcode:1995Sci...269.1439A. doi:10.1126/science.7660129. PMID 7660129. S2CID 37649908.
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". Science. 269 (5229): 1444–6. Bibcode:1995Sci...269.1444K. doi:10.1126/science.7660130. PMID 7660130. S2CID 25410108.
Bradsher JN, Jackson KW, Conaway RC, Conaway JW (1994). "RNA polymerase II transcription factor SIII. I. Identification, purification, and properties". J. Biol. Chem. 268 (34): 25587–93. doi:10.1016/S0021-9258(19)74431-7. PMID 8244996.
Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2156–61. Bibcode:1997PNAS...94.2156P. doi:10.1073/pnas.94.6.2156. PMC20057. PMID 9122164.
Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC317190. PMID 9765201.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. Bibcode:1999PNAS...96.2071Z. doi:10.1073/pnas.96.5.2071. PMC26738. PMID 10051596.
Stebbins CE, Kaelin WG, Pavletich NP (1999). "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function". Science. 284 (5413): 455–61. Bibcode:1999Sci...284..455S. doi:10.1126/science.284.5413.455. PMID 10205047.
Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD (1999). "Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9533–8. Bibcode:1999PNAS...96.9533P. doi:10.1073/pnas.96.17.9533. PMC22243. PMID 10449727.
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A (1999). "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12436–41. Bibcode:1999PNAS...9612436I. doi:10.1073/pnas.96.22.12436. PMC22941. PMID 10535940.
Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC481054. PMID 10587522.
Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M (2000). "Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis". J. Biol. Chem. 275 (9): 6546–52. doi:10.1074/jbc.275.9.6546. PMID 10692460.
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10430–5. Bibcode:2000PNAS...9710430K. doi:10.1073/pnas.190332597. PMC27041. PMID 10973499.
Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–62. doi:10.1074/jbc.M108269200. PMID 11739384.
Yamazaki K, Guo L, Sugahara K, Zhang C, Enzan H, Nakabeppu Y, Kitajima S, Aso T (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science. 296 (5574): 1886–9. Bibcode:2002Sci...296.1886M. doi:10.1126/science.1073440. PMID 12004076. S2CID 19641938.
Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY (2002). "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL". Nature. 417 (6892): 975–8. Bibcode:2002Natur.417..975H. doi:10.1038/nature00767. PMID 12050673. S2CID 4388644.
External linksedit
PDBe-KB provides an overview of all the structure information available in the PDB for Human Elongin-B
May 08, 2024
elob, elongin, protein, that, humans, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1lm8, 1lqb, 1vcb, 2c9w, 2izv, 2jz3, 2ma9, 3dcg, 3zkj, 3zng, 3zrc, 3zrf, 3ztc, 3ztd, 3zun, 4ajy, 4awj, 4b95, 4b9k, 4bks, 4bkt, 4n9f, 4w9c, . Elongin B is a protein that in humans is encoded by the ELOB gene 3 ELOBAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4IdentifiersAliasesELOB SIII TCEB2 transcription elongation factor B subunit 2 elongin BExternal IDsOMIM 600787 HomoloGene 134544 GeneCards ELOBGene location Human Chr Chromosome 16 human 1 Band16p13 3Start2 771 414 bp 1 End2 777 289 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumanterior pituitarynucleus accumbensprefrontal cortexganglionic eminenceamygdalacaudate nucleustrabecular bonegastrocnemius muscleleft adrenal glandn aMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding ubiquitin protein ligase bindingCellular componentCul2 RING ubiquitin ligase complex cytosol Cul5 RING ubiquitin ligase complex VCB complex nucleus elongin complex nucleoplasmBiological processtranscription elongation from RNA polymerase II promoter regulation of transcription DNA templated transcription by RNA polymerase II transcription DNA templated regulation of transcription from RNA polymerase II promoter in response to hypoxia protein ubiquitination post translational protein modification protein containing complex assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6923n aEnsemblENSG00000103363n aUniProtQ15370n aRefSeq mRNA NM 207013NM 007108n aRefSeq protein NP 009039NP 996896n aLocation UCSC Chr 16 2 77 2 78 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editElongin B is a subunit of the transcription factor B SIII complex The SIII complex is composed of elongins A A2 B and C It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units Elongin A functions as the transcriptionally active component of the SIII complex whereas elongins B and C are regulatory subunits Elongin A2 is specifically expressed in the testis and capable of forming a stable complex with elongins B and C The von Hippel Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation Two alternatively spliced transcript variants encoding different isoforms have been described for this gene 4 Interactions editTCEB2 has been shown to interact with CUL2 5 6 TCEB1 7 8 9 10 and Von Hippel Lindau tumor suppressor 5 8 11 12 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000103363 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Garrett KP Aso T Bradsher JN Foundling SI Lane WS Conaway RC Conaway JW September 1995 Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog Proc Natl Acad Sci U S A 92 16 7172 6 Bibcode 1995PNAS 92 7172G doi 10 1073 pnas 92 16 7172 PMC 41301 PMID 7638163 ELOB elongin B Homo sapiens human a b Menon S Tsuge T Dohmae N Takio K Wei N 2008 Association of SAP130 SF3b 3 with Cullin RING ubiquitin ligase complexes and its regulation by the COP9 signalosome BMC Biochem 9 1 doi 10 1186 1471 2091 9 1 PMC 2265268 PMID 18173839 Kamura T Burian D Yan Q Schmidt SL Lane WS Querido E Branton PE Shilatifard A Conaway RC Conaway JW August 2001 Muf1 a novel Elongin BC interacting leucine rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase J Biol Chem 276 32 29748 53 doi 10 1074 jbc M103093200 PMID 11384984 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 a b Ohh M Takagi Y Aso T Stebbins CE Pavletich NP Zbar B Conaway RC Conaway JW Kaelin WG Dec 1999 Synthetic peptides define critical contacts between elongin C elongin B and the von Hippel Lindau protein J Clin Invest 104 11 1583 91 doi 10 1172 JCI8161 PMC 481054 PMID 10587522 Krumm A Groudine M September 1995 Tumor suppression and transcription elongation the dire consequences of changing partners Science 269 5229 1400 1 Bibcode 1995Sci 269 1400K doi 10 1126 science 7660121 PMID 7660121 S2CID 39758696 Li Z Na X Wang D Schoen SR Messing EM Wu G February 2002 Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel Lindau tumor suppressor protein J Biol Chem 277 7 4656 62 doi 10 1074 jbc M108269200 PMID 11739384 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Min JH Yang H Ivan M Gertler F Kaelin WG Pavletich NP June 2002 Structure of an HIF 1alpha pVHL complex hydroxyproline recognition in signaling Science 296 5574 1886 9 Bibcode 2002Sci 296 1886M doi 10 1126 science 1073440 PMID 12004076 S2CID 19641938 Hacker KE Lee CM Rathmell WK 2008 Zhang B ed VHL type 2B mutations retain VBC complex form and function PLOS ONE 3 11 e3801 Bibcode 2008PLoSO 3 3801H doi 10 1371 journal pone 0003801 PMC 2583047 PMID 19030229 Further reading editDuan DR Pause A Burgess WH Aso T Chen DY Garrett KP Conaway RC Conaway JW Linehan WM Klausner RD 1995 Inhibition of transcription elongation by the VHL tumor suppressor protein Science 269 5229 1402 6 Bibcode 1995Sci 269 1402D doi 10 1126 science 7660122 PMID 7660122 S2CID 22334719 Aso T Lane WS Conaway JW Conaway RC 1995 Elongin SIII a multisubunit regulator of elongation by RNA polymerase II Science 269 5229 1439 43 Bibcode 1995Sci 269 1439A doi 10 1126 science 7660129 PMID 7660129 S2CID 37649908 Kibel A Iliopoulos O DeCaprio JA Kaelin WG 1995 Binding of the von Hippel Lindau tumor suppressor protein to Elongin B and C Science 269 5229 1444 6 Bibcode 1995Sci 269 1444K doi 10 1126 science 7660130 PMID 7660130 S2CID 25410108 Bradsher JN Jackson KW Conaway RC Conaway JW 1994 RNA polymerase II transcription factor SIII I Identification purification and properties J Biol Chem 268 34 25587 93 doi 10 1016 S0021 9258 19 74431 7 PMID 8244996 Pause A Lee S Worrell RA Chen DY Burgess WH Linehan WM Klausner RD 1997 The von Hippel Lindau tumor suppressor gene product forms a stable complex with human CUL 2 a member of the Cdc53 family of proteins Proc Natl Acad Sci U S A 94 6 2156 61 Bibcode 1997PNAS 94 2156P doi 10 1073 pnas 94 6 2156 PMC 20057 PMID 9122164 Li XY Green MR 1998 The HIV 1 Tat cellular coactivator Tat SF1 is a general transcription elongation factor Genes Dev 12 19 2992 6 doi 10 1101 gad 12 19 2992 PMC 317190 PMID 9765201 Zhang JG Farley A Nicholson SE Willson TA Zugaro LM Simpson RJ Moritz RL Cary D Richardson R Hausmann G Kile BJ Kent SB Alexander WS Metcalf D Hilton DJ Nicola NA Baca M 1999 The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Proc Natl Acad Sci U S A 96 5 2071 6 Bibcode 1999PNAS 96 2071Z doi 10 1073 pnas 96 5 2071 PMC 26738 PMID 10051596 Stebbins CE Kaelin WG Pavletich NP 1999 Structure of the VHL ElonginC ElonginB complex implications for VHL tumor suppressor function Science 284 5413 455 61 Bibcode 1999Sci 284 455S doi 10 1126 science 284 5413 455 PMID 10205047 Pause A Peterson B Schaffar G Stearman R Klausner RD 1999 Studying interactions of four proteins in the yeast two hybrid system structural resemblance of the pVHL elongin BC hCUL 2 complex with the ubiquitin ligase complex SKP1 cullin F box protein Proc Natl Acad Sci U S A 96 17 9533 8 Bibcode 1999PNAS 96 9533P doi 10 1073 pnas 96 17 9533 PMC 22243 PMID 10449727 Iwai K Yamanaka K Kamura T Minato N Conaway RC Conaway JW Klausner RD Pause A 1999 Identification of the von Hippel lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex Proc Natl Acad Sci U S A 96 22 12436 41 Bibcode 1999PNAS 9612436I doi 10 1073 pnas 96 22 12436 PMC 22941 PMID 10535940 Ohh M Takagi Y Aso T Stebbins CE Pavletich NP Zbar B Conaway RC Conaway JW Kaelin WG 2000 Synthetic peptides define critical contacts between elongin C elongin B and the von Hippel Lindau protein J Clin Invest 104 11 1583 91 doi 10 1172 JCI8161 PMC 481054 PMID 10587522 Aso T Yamazaki K Amimoto K Kuroiwa A Higashi H Matsuda Y Kitajima S Hatakeyama M 2000 Identification and characterization of Elongin A2 a new member of the Elongin family of transcription elongation factors specifically expressed in the testis J Biol Chem 275 9 6546 52 doi 10 1074 jbc 275 9 6546 PMID 10692460 Kamura T Sato S Iwai K Czyzyk Krzeska M Conaway RC Conaway JW 2000 Activation of HIF1alpha ubiquitination by a reconstituted von Hippel Lindau VHL tumor suppressor complex Proc Natl Acad Sci U S A 97 19 10430 5 Bibcode 2000PNAS 9710430K doi 10 1073 pnas 190332597 PMC 27041 PMID 10973499 Aso T Yamazaki K Aigaki T Kitajima S 2000 Drosophila von Hippel Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity Biochem Biophys Res Commun 276 1 355 61 doi 10 1006 bbrc 2000 3451 PMID 11006129 Kamura T Burian D Yan Q Schmidt SL Lane WS Querido E Branton PE Shilatifard A Conaway RC Conaway JW 2001 Muf1 a novel Elongin BC interacting leucine rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase J Biol Chem 276 32 29748 53 doi 10 1074 jbc M103093200 PMID 11384984 Li Z Na X Wang D Schoen SR Messing EM Wu G 2002 Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel Lindau tumor suppressor protein J Biol Chem 277 7 4656 62 doi 10 1074 jbc M108269200 PMID 11739384 Yamazaki K Guo L Sugahara K Zhang C Enzan H Nakabeppu Y Kitajima S Aso T 2002 Identification and biochemical characterization of a novel transcription elongation factor Elongin A3 J Biol Chem 277 29 26444 51 doi 10 1074 jbc M202859200 PMID 11994304 Min JH Yang H Ivan M Gertler F Kaelin WG Pavletich NP 2002 Structure of an HIF 1alpha pVHL complex hydroxyproline recognition in signaling Science 296 5574 1886 9 Bibcode 2002Sci 296 1886M doi 10 1126 science 1073440 PMID 12004076 S2CID 19641938 Hon WC Wilson MI Harlos K Claridge TD Schofield CJ Pugh CW Maxwell PH Ratcliffe PJ Stuart DI Jones EY 2002 Structural basis for the recognition of hydroxyproline in HIF 1 alpha by pVHL Nature 417 6892 975 8 Bibcode 2002Natur 417 975H doi 10 1038 nature00767 PMID 12050673 S2CID 4388644 External links editPDBe KB provides an overview of all the structure information available in the PDB for Human Elongin B Retrieved from https en wikipedia org w index php title ELOB amp oldid 1188028951, wikipedia, wiki, book, books, library,
