T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.[1] Their presence indicates maturation of T cells; TRECs are reduced in SCID (Severe combined immunodeficiency disease).
Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample.[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).[3]
^Zhang, S. L.; Bhandoola, A. (2012). "Losing TREC with age". Immunity. 36 (2): 163–165. doi:10.1016/j.immuni.2012.02.005. PMC4026262. PMID 22365662.
^Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A (2000). "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods. 237 (1–2): 187–97. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.
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cell, receptor, excision, circles, trecs, small, circles, created, cells, during, their, passage, through, thymus, they, rearrange, their, genes, their, presence, indicates, maturation, cells, trecs, reduced, scid, severe, combined, immunodeficiency, disease, . T cell receptor excision circles TRECs are small circles of DNA created in T cells during their passage through the thymus as they rearrange their TCR genes 1 Their presence indicates maturation of T cells TRECs are reduced in SCID Severe combined immunodeficiency disease Signal joint T cell receptor excision circles sjTRECs might be used as a way to test the age of the individual from a blood sample 2 The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output e g following hematopoietic stem cell transplantation or in cases of AIDS 3 See also EditT cell receptor V D J recombinationReferences Edit http allergycases org 2010 05 t cell receptor excision circles trecs html full citation needed Zhang S L Bhandoola A 2012 Losing TREC with age Immunity 36 2 163 165 doi 10 1016 j immuni 2012 02 005 PMC 4026262 PMID 22365662 Al Harthi L Marchetti G Steffens CM Poulin J Sekaly R Landay A 2000 Detection of T cell receptor circles TRECs as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction enzyme linked immunosorbent assay PCR ELISA Journal of Immunological Methods 237 1 2 187 97 doi 10 1016 S0022 1759 00 00136 8 PMID 10725462 This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title T cell receptor excision circles amp oldid 945333585, wikipedia, wiki, book, books, library,
