A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. There are three types of suppositories, each to insert into a different sections: rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male.
Suppositories are ideal for infants, elderly individuals and post-operative patients, who are unable to swallow oral medications, and for individuals experiencing severe nausea and/or vomiting.[1][2][3]
Several different ingredients can be used to form the base of a suppository: cocoa butter or a similar substitute, polyethylene glycol, hydrogels, and glycerinated gelatin. The type of material used depends on the type of suppository, the type of drug, and the conditions in which the suppository will be stored.[4]
In 1991, a study on suppository insertion in The Lancet found that the "torpedo" shape helps the device to travel internally, increasing its efficacy.[5] The findings of this single study have been challenged as there is insufficient evidence on which to base clinical practice.[6] Rectal suppositories are intended for localized or systemic action to relieve pain, constipation, irritation, inflammation, nausea and vomiting, fever, migraines, allergies, and sedation.[7][8]
Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction (impotence). They are marketed under the name Muse in the United States.[9] Its use has diminished since the development of oral impotence medications.
^Jannin, Vincent; Lemagnen, Gilles; Gueroult, Pascale; Larrouture, Denis; Tuleu, Catherine (2014-06-30). "Rectal route in the 21st Century to treat children". Advanced Drug Delivery Reviews. Drug delivery and the paediatric population: where are we at?. 73: 34–49. doi:10.1016/j.addr.2014.05.012. ISSN 0169-409X. PMID 24871671.
^Lowry, Michael (2016-02-22). "Rectal drug administration in adults: how, when, why". Nursing Times. Vol. 112, no. 8, 12–14. Retrieved 2022-04-10.
^Troy, David B.; Beringer, Paul (2006). Remington: The Science and Practice of Pharmacy. Lippincott Williams & Wilkins. pp. 884–885. ISBN9780781746731.
^Abd-El-Maeboud, K. H.; T. El-Naggar; E. M. M. El-Hawi; S. A. R. Mahmoud; S. Abd-El-Hay (28 September 1991). "Rectal suppository: commonsense and mode of insertion". The Lancet. 338 (8770): 798–800. doi:10.1016/0140-6736(91)90676-G. PMID 1681170. S2CID 23190075.
^Bradshaw, Ann; Lynda Price (20 December 2006). (PDF). Journal of Clinical Nursing. 16 (1): 98–103. doi:10.1111/j.1365-2702.2005.01519.x. PMID 17181671. Archived from the original (PDF) on 2020-02-29.
^Hua, Susan (2019-10-16). "Physiological and Pharmaceutical Considerations for Rectal Drug Formulations". Frontiers in Pharmacology. 10: 1196. doi:10.3389/fphar.2019.01196. ISSN 1663-9812. PMC6805701. PMID 31680970.
^"ANTIBIOTIC/ANESTHETIC/STEROID - RECTAL SUPPOSITORIES side effects, medical uses, and drug interactions". MedicineNet. Retrieved 2021-12-11.
^"Muse Suppository - Facts and Comparisons". Drugs.com. Retrieved 4 January 2013.
References
Doyle, D., "Per Rectum: A History of Enemata", Journal of the Royal College of Physicians of Edinburgh, Vol.35, No.4, (December 2005), pp. 367–370.
Payer, L., "Borderline Cases: How Medical Practice Reflects National Culture", The Sciences, Vol.30, No.4, (July–August 1990), pp. 38–42.
This article related to medical equipment is a stub. You can help Wikipedia by expanding it.
suppository, this, article, provides, insufficient, context, those, unfamiliar, with, subject, please, help, improve, article, providing, more, context, reader, november, 2021, learn, when, remove, this, template, message, suppository, dosage, form, used, deli. This article provides insufficient context for those unfamiliar with the subject Please help improve the article by providing more context for the reader November 2021 Learn how and when to remove this template message A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects There are three types of suppositories each to insert into a different sections rectal suppositories into the rectum vaginal suppositories into the vagina and urethral suppositories into the urethra of a male Suppositories are ideal for infants elderly individuals and post operative patients who are unable to swallow oral medications and for individuals experiencing severe nausea and or vomiting 1 2 3 Contents 1 Composition 2 Rectal suppositories 3 Urethral suppositories 4 See also 5 Notes 6 ReferencesComposition EditSeveral different ingredients can be used to form the base of a suppository cocoa butter or a similar substitute polyethylene glycol hydrogels and glycerinated gelatin The type of material used depends on the type of suppository the type of drug and the conditions in which the suppository will be stored 4 Rectal suppositories Edit Glycerin suppositories laxative In 1991 a study on suppository insertion in The Lancet found that the torpedo shape helps the device to travel internally increasing its efficacy 5 The findings of this single study have been challenged as there is insufficient evidence on which to base clinical practice 6 Rectal suppositories are intended for localized or systemic action to relieve pain constipation irritation inflammation nausea and vomiting fever migraines allergies and sedation 7 8 Four 500 mg paracetamol suppositoriesUrethral suppositories EditAlprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction impotence They are marketed under the name Muse in the United States 9 Its use has diminished since the development of oral impotence medications See also Edit Wikimedia Commons has media related to Suppository category Artesunate suppositories Enema PessaryNotes Edit Jannin Vincent Lemagnen Gilles Gueroult Pascale Larrouture Denis Tuleu Catherine 2014 06 30 Rectal route in the 21st Century to treat children Advanced Drug Delivery Reviews Drug delivery and the paediatric population where are we at 73 34 49 doi 10 1016 j addr 2014 05 012 ISSN 0169 409X PMID 24871671 Dulcolax 5 mg Suppositories Summary of Product Characteristics SmPC emc www medicines org uk Retrieved 2021 12 11 Lowry Michael 2016 02 22 Rectal drug administration in adults how when why Nursing Times Vol 112 no 8 12 14 Retrieved 2022 04 10 Troy David B Beringer Paul 2006 Remington The Science and Practice of Pharmacy Lippincott Williams amp Wilkins pp 884 885 ISBN 9780781746731 Abd El Maeboud K H T El Naggar E M M El Hawi S A R Mahmoud S Abd El Hay 28 September 1991 Rectal suppository commonsense and mode of insertion The Lancet 338 8770 798 800 doi 10 1016 0140 6736 91 90676 G PMID 1681170 S2CID 23190075 Bradshaw Ann Lynda Price 20 December 2006 Rectal suppository insertion the reliability of the evidence as a basis for nursing practice PDF Journal of Clinical Nursing 16 1 98 103 doi 10 1111 j 1365 2702 2005 01519 x PMID 17181671 Archived from the original PDF on 2020 02 29 Hua Susan 2019 10 16 Physiological and Pharmaceutical Considerations for Rectal Drug Formulations Frontiers in Pharmacology 10 1196 doi 10 3389 fphar 2019 01196 ISSN 1663 9812 PMC 6805701 PMID 31680970 ANTIBIOTIC ANESTHETIC STEROID RECTAL SUPPOSITORIES side effects medical uses and drug interactions MedicineNet Retrieved 2021 12 11 Muse Suppository Facts and Comparisons Drugs com Retrieved 4 January 2013 References EditDoyle D Per Rectum A History of Enemata Journal of the Royal College of Physicians of Edinburgh Vol 35 No 4 December 2005 pp 367 370 Payer L Borderline Cases How Medical Practice Reflects National Culture The Sciences Vol 30 No 4 July August 1990 pp 38 42 This article related to medical equipment is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Suppository amp oldid 1121648306, wikipedia, wiki, book, books, library,
