Steven S. Rosenfeld (born 1953) is an American biochemist and former researcher, who was found to have published irreproducible research, as well as having forged recommendations for himself.[1] This was one of the first events which brought the issue of scientific misconduct to the attention of the scientific community and the American public.[2][3][4]
Scientific misconductedit
Rosenfeld was a Harvard undergraduate (Class of 1975) doing research on transfer factor in the laboratory of Dr. David Dressler. His research showed that a subcellular fraction prepared from cells of the immune system of an animal having cell-mediated immunity to the hapten dinitrochlorobenzene could transfer that specific immunity to a second, previously non-immune animal. Further it showed that the active component of this transfer factor appeared to be RNA.[5][6]
It was soon discovered that Rosenfeld had forged various letters of recommendation for himself and signed Dressler's name to them. This led to re-examination of Rosenfeld's experiments, which could not be successfully repeated by other scientists. Two articles describing Rosenfeld's research on transfer factor had been published in Proceedings of the National Academy of Sciences. Subsequently, Dressler published an Authors' Statement "about the existence and nature of 'transfer factor'" in this same journal, making a "statement of uncertainty and potential retraction with our sincere apologies".[7] Similarly, an article published in Annals of Internal Medicine[8] was withdrawn.[9]
^"Immunological Immunity: The Rosenfeld Case | News | The Harvard Crimson". www.thecrimson.com. 28 February 1975. Retrieved 21 December 2018.
^ abChedd G (1974-12-26). "Transfer factor - Another scandal?". New Scientist. Vol. 64, no. 929. pp. 920–1.
^ abReinhold, Robert (16 December 1974). "Student's Forgery Perils Key Harvard Research". The New York Times.
^ ab"Science: The Model Student". Time. 30 December 1974.
^Rosenfeld, S; Dressler, D (June 1974). "Transfer factor: a subcellular component that transmits information for specific immune responses". Proceedings of the National Academy of Sciences of the United States of America. 71 (6): 2473–7. Bibcode:1974PNAS...71.2473R. doi:10.1073/pnas.71.6.2473. PMC388481. PMID 4135308.
^Dressler, D; Rosenfeld, S (November 1974). "On the chemical nature of transfer factor". Proceedings of the National Academy of Sciences of the United States of America. 71 (11): 4429–34. Bibcode:1974PNAS...71.4429D. doi:10.1073/pnas.71.11.4429. PMC433899. PMID 4530993.
^Dressler, D; Potter, H (January 1975). "Authors' statement: the existence and nature of "transfer factor/be/". Proceedings of the National Academy of Sciences of the United States of America. 72 (1): 409. Bibcode:1975PNAS...72..409D. doi:10.1073/pnas.72.1.409-b. PMC432317. PMID 1088829.
^Potter, H; Rosenfeld, S; Dressler, D (December 1974). "Transfer factor". Annals of Internal Medicine. 81 (6): 838–47. doi:10.7326/0003-4819-81-6-838. PMID 4530646.
^Dressler, D; Potter, H (February 1975). "Transfer factor: warning on uncertainty of results". Annals of Internal Medicine. 82 (2): 279. doi:10.7326/0003-4819-82-2-279_1. PMID 1115452.
^Reinhold, Robert (29 December 1974). "Research Pressures Are Great, As Are the Rewards". The New York Times.
November 23, 2023
steven, rosenfeld, born, 1953, american, biochemist, former, researcher, found, have, published, irreproducible, research, well, having, forged, recommendations, himself, this, first, events, which, brought, issue, scientific, misconduct, attention, scientific. Steven S Rosenfeld born 1953 is an American biochemist and former researcher who was found to have published irreproducible research as well as having forged recommendations for himself 1 This was one of the first events which brought the issue of scientific misconduct to the attention of the scientific community and the American public 2 3 4 Scientific misconduct editRosenfeld was a Harvard undergraduate Class of 1975 doing research on transfer factor in the laboratory of Dr David Dressler His research showed that a subcellular fraction prepared from cells of the immune system of an animal having cell mediated immunity to the hapten dinitrochlorobenzene could transfer that specific immunity to a second previously non immune animal Further it showed that the active component of this transfer factor appeared to be RNA 5 6 It was soon discovered that Rosenfeld had forged various letters of recommendation for himself and signed Dressler s name to them This led to re examination of Rosenfeld s experiments which could not be successfully repeated by other scientists Two articles describing Rosenfeld s research on transfer factor had been published in Proceedings of the National Academy of Sciences Subsequently Dressler published an Authors Statement about the existence and nature of transfer factor in this same journal making a statement of uncertainty and potential retraction with our sincere apologies 7 Similarly an article published in Annals of Internal Medicine 8 was withdrawn 9 This incident along with the contemporary falsification of data by William Summerlin at Memorial Sloan Kettering Cancer Center was one of the first events which brought the issue of scientific misconduct to the attention of the scientific community and the American public 2 3 4 10 References edit Immunological Immunity The Rosenfeld Case News The Harvard Crimson www thecrimson com 28 February 1975 Retrieved 21 December 2018 a b Chedd G 1974 12 26 Transfer factor Another scandal New Scientist Vol 64 no 929 pp 920 1 a b Reinhold Robert 16 December 1974 Student s Forgery Perils Key Harvard Research The New York Times a b Science The Model Student Time 30 December 1974 Rosenfeld S Dressler D June 1974 Transfer factor a subcellular component that transmits information for specific immune responses Proceedings of the National Academy of Sciences of the United States of America 71 6 2473 7 Bibcode 1974PNAS 71 2473R doi 10 1073 pnas 71 6 2473 PMC 388481 PMID 4135308 Dressler D Rosenfeld S November 1974 On the chemical nature of transfer factor Proceedings of the National Academy of Sciences of the United States of America 71 11 4429 34 Bibcode 1974PNAS 71 4429D doi 10 1073 pnas 71 11 4429 PMC 433899 PMID 4530993 Dressler D Potter H January 1975 Authors statement the existence and nature of transfer factor be Proceedings of the National Academy of Sciences of the United States of America 72 1 409 Bibcode 1975PNAS 72 409D doi 10 1073 pnas 72 1 409 b PMC 432317 PMID 1088829 Potter H Rosenfeld S Dressler D December 1974 Transfer factor Annals of Internal Medicine 81 6 838 47 doi 10 7326 0003 4819 81 6 838 PMID 4530646 Dressler D Potter H February 1975 Transfer factor warning on uncertainty of results Annals of Internal Medicine 82 2 279 doi 10 7326 0003 4819 82 2 279 1 PMID 1115452 Reinhold Robert 29 December 1974 Research Pressures Are Great As Are the Rewards The New York Times Retrieved from https en wikipedia org w index php title Steven S Rosenfeld amp oldid 1050759360, wikipedia, wiki, book, books, library,
