A specificity factor is an amino acid sequence that mediates target recognition in RNA polymerase.[1] An example is the sigma subunit of the Escherichia coli RNA polymerase holoenzyme which regulates a binding σ subunit of molecular weight 70 kDa. Under some conditions, some of the 70-kDa subunits are replaced by one of the other, more-specific factors. For instance, when bacteria are subjected to heat stress, some of the 70-kDa subunits are replaced by a 32-kDa subunit; when bound to σ32, RNA polymerase is directed to a specialized set of promoters with a different consensus sequence.
Referencesedit
^Jang, Sei Heon; Jaehnings, Judith A. (1991). "The Yeast Mitochondrial RNA Polymerase Specificity Factor, MTF1, Is Similar to Bacterial 0 Factors" (PDF). The Journal of Biological Chemistry. 266 (39): 22671–22677. doi:10.1016/S0021-9258(18)54622-6.
specificity, factor, this, article, needs, additional, citations, verification, please, help, improve, this, article, adding, citations, reliable, sources, unsourced, material, challenged, removed, find, sources, news, newspapers, books, scholar, jstor, novemb. This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Specificity factor news newspapers books scholar JSTOR November 2017 Learn how and when to remove this message A specificity factor is an amino acid sequence that mediates target recognition in RNA polymerase 1 An example is the sigma subunit of the Escherichia coli RNA polymerase holoenzyme which regulates a binding s subunit of molecular weight 70 kDa Under some conditions some of the 70 kDa subunits are replaced by one of the other more specific factors For instance when bacteria are subjected to heat stress some of the 70 kDa subunits are replaced by a 32 kDa subunit when bound to s32 RNA polymerase is directed to a specialized set of promoters with a different consensus sequence References edit Jang Sei Heon Jaehnings Judith A 1991 The Yeast Mitochondrial RNA Polymerase Specificity Factor MTF1 Is Similar to Bacterial 0 Factors PDF The Journal of Biological Chemistry 266 39 22671 22677 doi 10 1016 S0021 9258 18 54622 6 nbsp This molecular biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Specificity factor amp oldid 1163311183, wikipedia, wiki, book, books, library,
