SpeF is a putative cis-acting element identified in several gram negative alpha proteobacteria. It is proposed to be involved in regulating expression of genes involved in polyamidebiosynthesis.
SpeF is one of five putative regulatory elements identified by a computational screen of Agrobacterium tumefaciens and other alpha-proteobacterial genomes for conserved sequence motifs in operon leaders.[1] In the majority of species analysed it is located in the leader of an operon containing the speF gene an ornithine decarboxylase enzyme that catalyses one of the first steps in polyamine biosynthesis. However, the authors did not detect binding of metabolites related to this pathway (L-ornithine, L-lysine, meso-diaminopimelate, putrescine, cadaverine, or spermidine) to the SpeF leader.[1]
Other non-coding RNAs uncovered in the same analysis include: suhB, ybhL, metA and serC.[1]
Referencesedit
^ abcCorbino KA, Barrick JE, Lim J, et al. (2005). "Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria". Genome Biol. 6 (8): R70. doi:10.1186/gb-2005-6-8-r70. PMC1273637. PMID 16086852.
spef, leader, spef, putative, acting, element, identified, several, gram, negative, alpha, proteobacteria, proposed, involved, regulating, expression, genes, involved, polyamide, biosynthesis, spef, leaderpredicted, secondary, structure, sequence, conservation. SpeF is a putative cis acting element identified in several gram negative alpha proteobacteria It is proposed to be involved in regulating expression of genes involved in polyamide biosynthesis speF leaderPredicted secondary structure and sequence conservation of speFIdentifiersSymbolspeFRfamRF00518Other dataRNA typeCis reg leaderDomain s BacteriaSOSO 0005836PDB structuresPDBeSpeF is one of five putative regulatory elements identified by a computational screen of Agrobacterium tumefaciens and other alpha proteobacterial genomes for conserved sequence motifs in operon leaders 1 In the majority of species analysed it is located in the leader of an operon containing the speF gene an ornithine decarboxylase enzyme that catalyses one of the first steps in polyamine biosynthesis However the authors did not detect binding of metabolites related to this pathway L ornithine L lysine meso diaminopimelate putrescine cadaverine or spermidine to the SpeF leader 1 Other non coding RNAs uncovered in the same analysis include suhB ybhL metA and serC 1 References edit a b c Corbino KA Barrick JE Lim J et al 2005 Evidence for a second class of S adenosylmethionine riboswitches and other regulatory RNA motifs in alpha proteobacteria Genome Biol 6 8 R70 doi 10 1186 gb 2005 6 8 r70 PMC 1273637 PMID 16086852 External links editPage for speF leader at Rfam nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SpeF leader amp oldid 1189768153, wikipedia, wiki, book, books, library,
