Simon's reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It reacts with secondary amines like MDMA and methamphetamine to give a blue solution.
The primary use of this reagent is for detecting secondary amines, such as MDMA and methamphetamine, and is typically used after the mecke or marquis reagents to differentiate between the two mentioned and amphetamine or MDA.[1]
Chemistryedit
The reagent is typically provided in two parts:[2][1][3]
Separate storage of the aldehyde and base are necessary to prevent aldol polymerisation of the aldehyde.
When exposed to an amine, reaction with acetaldehyde produces the enamine, which subsequently reacts with sodium nitroprusside to the imine. Finally, the iminium salt is hydrolysed to the bright blue[1] Simon-Awe complex.[3][5]
^ abc. Dancesafe. Archived from the original on 2014-02-15. Retrieved 2012-01-30.
^Thompson, Robert; Thompson, Barbara Fritchman (2012-08-14). Illustrated Guide to Home Forensic Science Experiments: All Lab, No Lecture. "O'Reilly Media, Inc.". p. 255. ISBN978-1-4493-3451-2.
^ abc"Chemistry and Reaction Mechanisms of Rapid Tests for Drugs of Abuse and Precursors Chemicals" (PDF). UNODC. Retrieved 2012-01-30.
^ ab"Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse" (PDF). Law Enforcement and Corrections Standards and Testing Program. July 2000. Retrieved 2011-07-24.
^Leeuwenkamp, O. R.; van Bennekom, W. P.; van der Mark, E. J.; Bult, A. (1984). "Nitroprusside, antihypertensive drug and analytical reagent". Pharmaceutisch Weekblad. 6 (4): 129–140. doi:10.1007/BF01954040. ISSN 0031-6911. PMID 6384923. S2CID 21283981.
April 12, 2024
simon, reagent, used, simple, spot, test, presumptively, identify, alkaloids, well, other, compounds, reacts, with, secondary, amines, like, mdma, methamphetamine, give, blue, solution, contents, uses, chemistry, testing, method, also, referencesuses, editthe,. Simon s reagent is used as a simple spot test to presumptively identify alkaloids as well as other compounds It reacts with secondary amines like MDMA and methamphetamine to give a blue solution Contents 1 Uses 2 Chemistry 2 1 Testing Method 3 See also 4 ReferencesUses editThe primary use of this reagent is for detecting secondary amines such as MDMA and methamphetamine and is typically used after the mecke or marquis reagents to differentiate between the two mentioned and amphetamine or MDA 1 Chemistry editThe reagent is typically provided in two parts 2 1 3 A mixture of 2 sodium nitroprusside and 2 acetaldehyde in water solution A 4 A solution of 2 sodium carbonate in water solution B 4 Separate storage of the aldehyde and base are necessary to prevent aldol polymerisation of the aldehyde When exposed to an amine reaction with acetaldehyde produces the enamine which subsequently reacts with sodium nitroprusside to the imine Finally the iminium salt is hydrolysed to the bright blue 1 Simon Awe complex 3 5 Acetaldehyde can be replaced with acetone in which case the reagent detects primary amines instead giving a purple coloured product 3 Testing Method edit A drop from each solution A and B is dripped onto the substance being tested causing the two solutions to mix together See also editDrug checking Dille Koppanyi reagent Folin s reagent Froehde reagent Liebermann reagent Mandelin reagent Marquis reagent Mecke reagent Zwikker reagentReferences edit a b c Simon s Reagent Testing Kit Yellow amp Green Labels Dancesafe Archived from the original on 2014 02 15 Retrieved 2012 01 30 Thompson Robert Thompson Barbara Fritchman 2012 08 14 Illustrated Guide to Home Forensic Science Experiments All Lab No Lecture O Reilly Media Inc p 255 ISBN 978 1 4493 3451 2 a b c Chemistry and Reaction Mechanisms of Rapid Tests for Drugs of Abuse and Precursors Chemicals PDF UNODC Retrieved 2012 01 30 a b Color Test Reagents Kits for Preliminary Identification of Drugs of Abuse PDF Law Enforcement and Corrections Standards and Testing Program July 2000 Retrieved 2011 07 24 Leeuwenkamp O R van Bennekom W P van der Mark E J Bult A 1984 Nitroprusside antihypertensive drug and analytical reagent Pharmaceutisch Weekblad 6 4 129 140 doi 10 1007 BF01954040 ISSN 0031 6911 PMID 6384923 S2CID 21283981 Retrieved from https en wikipedia org w index php title Simon 27s reagent amp oldid 1125471130, wikipedia, wiki, book, books, library,
