Sean Curran (scientist)

Sean Curran is an American gerontologist who is Professor of Gerontology and Vice Dean at the USC Davis School of Gerontology with joint appointments in Molecular and Computational Biology (USC Dana and David Dornsife College of Letters, Arts and Sciences). He also serves as the Dean of Faculty and Research. His expertise is the molecular genetics of healthspan and longevity^[1] with an emphasis on biology, genetics, nutrition, and diets.

Education

Curran earned his B.S. from UCLA in 1999, his Ph.D. from UCLA in 2004 and completed postdoctoral training at Harvard Medical School and Massachusetts General Hospital from 2004-2010.^[2]

Research

Curran and his co-author Gary Ruvkun discovered approximately 60 highly conserved genes that are essential for development but can significantly increase lifespan when inactivated in adulthood.^[3][4]

Curran’s research group has established the existence of gene-diet pairs that predict survival and aging success. The function of these genes is essential on some diets but dispensable on others [1-2]. There are potentially hundreds, if not thousands of these gene-diet pairs, which when combined, may explain the variance in aging rates across individuals.

Awards

• 2014 Nathan Shock Award – Gerontological Society of America^{[citation needed]}
• 2015 Ewald Busse Award – Duke Center for the Study of Aging and Human Development^{[citation needed]}
• 2020 Vincent Cristofalo Rising Star Award in Aging Research, American Federation for Aging Research (AFAR)

Selected publications

• Pang, S; Curran, SP (Feb 2014). "Adaptive capacity to bacterial diet modulates aging in C. elegans". Cell Metab. 19 (2): 221–31. doi:10.1016/j.cmet.2013.12.005. PMC 3979424. PMID 24440036.
• Curran, SP; Wu, X; Riedel, C; Ruvkun, G (Jun 2009). "A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants". Nature. 459 (7250): 1079–84. Bibcode:2009Natur.459.1079C. doi:10.1038/nature08106. PMC 2716045. PMID 19506556.
• Curran, SP; Ruvkun, G (2007). "Lifespan regulation by evolutionarily conserved genes essential for viability". PLOS Genet. 3 (4): e56. doi:10.1371/journal.pgen.0030056.eor. PMC 1847696. PMID 17411345.

References

1. "Sean Curran Faculty Profile". USC Davis School of Gerontology. Retrieved 6 April 2016.
2. . Archived from the original on 18 March 2012. Retrieved 20 March 2012.
3. Wade, Nicholas (9 June 2009). "In Worms, Genetic Clues to Extending Longevity". The New York Times. Retrieved 20 March 2012.
4. Keim, Brandon (8 June 2009). "The Secret to Roundworm Longevity: Sex Cells". Wired. Retrieved 21 March 2012.

• Pang, S., et al., SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation. Nat Commun, 2014. 5: p. 5048.
• https://www.geron.org/press-room/press-releases/2014-press-releases/371-curran-to-receive-gsa-s-2014-nathan-shock-new-investigator-award
• https://www.geron.org/membership/awards/awardees?showall=1