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SOS box

January 01, 1970

SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription of SOS-induced proteins. This occurs in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator. SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism.[1] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[2]

Examples edit

Phylogenetic Clade Sequence Reference
Alphaproteobacteria GAAC(N)7GAAC
GTTC(N)7GTTC 		[3][4]
Betaproteobacteria
Gammaproteobacteria 		CTGT(N)8ACAG [5]
Deltaproteobacteria CTRHAMRYBYGTTCAGS [6]
Gram-positive bacteria CGAACRNRYGTTYC [7][8]
Cyanobacteria RGTAC(N)3DGTWCB [9]

See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters.

See also edit

References edit

  1. ^ Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis". Trends in Biochemical Sciences. 20 (10): 416–20. doi:10.1016/s0968-0004(00)89091-x. PMID 8533155.
  2. ^ Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology. 154 (6): 1783–1792. doi:10.1099/mic.0.2007/016139-0. PMC 2729051. PMID 18524933.
  3. ^ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. doi:10.1046/j.1365-2958.1998.00860.x. PMID 9663685.
  4. ^ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. doi:10.1007/s004380051066. PMID 10503543. S2CID 2373618.
  5. ^ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics. 19 (17): 2225–36. doi:10.1093/bioinformatics/btg303. PMID 14630651.
  6. ^ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858.
  7. ^ Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. doi:10.1128/JB.180.8.2201-2211.1998. PMC 107149. PMID 9555905.
  8. ^ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. doi:10.1128/JB.184.12.3287-3295.2002. PMC 135081. PMID 12029045.
  9. ^ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics. 271 (1): 40–9. doi:10.1007/s00438-003-0952-x. PMID 14652736. S2CID 9219764.
  • Erill I, et al. (2004). "Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics". Nucleic Acids Research. 32 (22): 6617–26. doi:10.1093/nar/gkh996. PMC 545464. PMID 15604457.
  • Shinagawa H (1996). "SOS response as an adaptive response to DNA damage in prokaryotes". Stress-Inducible Cellular Responses. Vol. 77. pp. 221–35. doi:10.1007/978-3-0348-9088-5_14. ISBN 978-3-0348-9901-7. PMID 8856977. {{cite book}}: |journal= ignored (help)


 

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January 01, 1970
region, promoter, various, genes, which, lexa, repressor, binds, repress, transcription, induced, proteins, this, occurs, absence, damage, presence, damage, binding, lexa, inactivated, reca, activator, differ, sequences, binding, affinity, towards, lexa, from,. SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription of SOS induced proteins This occurs in the absence of DNA damage In the presence of DNA damage the binding of LexA is inactivated by the RecA activator SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism 1 Furthermore SOS boxes may be present in a dual fashion which indicates that more than one SOS box can be within the same promoter 2 Examples editPhylogenetic Clade Sequence Reference Alphaproteobacteria GAAC N 7GAACGTTC N 7GTTC 3 4 BetaproteobacteriaGammaproteobacteria CTGT N 8ACAG 5 Deltaproteobacteria CTRHAMRYBYGTTCAGS 6 Gram positive bacteria CGAACRNRYGTTYC 7 8 Cyanobacteria RGTAC N 3DGTWCB 9 See Nucleic acid nomenclature for an explanation of non GATC nucleotide letters See also editSOS response SOS gene LexA RecAReferences edit Walker GC October 1995 SOS regulated proteins in translesion DNA synthesis and mutagenesis Trends in Biochemical Sciences 20 10 416 20 doi 10 1016 s0968 0004 00 89091 x PMID 8533155 Gillor Osnat Vriezen Jan A C Riley Margaret A Jun 2008 The role of SOS boxes in enteric bacteriocin regulation Microbiology 154 6 1783 1792 doi 10 1099 mic 0 2007 016139 0 PMC 2729051 PMID 18524933 Fernandez de Henestrosa AR Rivera E Tapias A Barbe J June 1998 Identification of the Rhodobacter sphaeroides SOS box Mol Microbiol 28 5 991 1003 doi 10 1046 j 1365 2958 1998 00860 x PMID 9663685 Tapias A Barbe J August 1999 Regulation of divergent transcription from the uvrA ssb promoters in Sinorhizobium meliloti Mol Gen Genet 262 1 121 30 doi 10 1007 s004380051066 PMID 10503543 S2CID 2373618 Erill I Escribano M Campoy S Barbe J November 2003 In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA regulon Bioinformatics 19 17 2225 36 doi 10 1093 bioinformatics btg303 PMID 14630651 Campoy S Fontes M Padmanabhan S Cortes P Llagostera M Barbe J August 2003 LexA independent DNA damage mediated induction of gene expression in Myxococcus xanthus Mol Microbiol 49 3 769 81 doi 10 1046 j 1365 2958 2003 03592 x PMID 12864858 Winterling KW Chafin D Hayes JJ et al 15 April 1998 The Bacillus subtilis DinR Binding Site Redefinition of the Consensus Sequence J Bacteriol 180 8 2201 11 doi 10 1128 JB 180 8 2201 2211 1998 PMC 107149 PMID 9555905 Davis EO Dullaghan EM Rand L June 2002 Definition of the Mycobacterial SOS Box and Use To Identify LexA Regulated Genes in Mycobacterium tuberculosis J Bacteriol 184 12 3287 95 doi 10 1128 JB 184 12 3287 3295 2002 PMC 135081 PMID 12029045 Mazon G Lucena JM Campoy S Fernandez de Henestrosa AR Candau P Barbe J February 2004 LexA binding sequences in Gram positive and cyanobacteria are closely related Mol Genet Genomics 271 1 40 9 doi 10 1007 s00438 003 0952 x PMID 14652736 S2CID 9219764 Erill I et al 2004 Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics Nucleic Acids Research 32 22 6617 26 doi 10 1093 nar gkh996 PMC 545464 PMID 15604457 Shinagawa H 1996 SOS response as an adaptive response to DNA damage in prokaryotes Stress Inducible Cellular Responses Vol 77 pp 221 35 doi 10 1007 978 3 0348 9088 5 14 ISBN 978 3 0348 9901 7 PMID 8856977 a href Template Cite book html title Template Cite book cite book a journal ignored help nbsp This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SOS box amp oldid 1172277586, wikipedia, wiki, book, books, library,

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