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Wikipedia

SLC22A11

April 10, 2024

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.[3][4][5][6]

SLC22A11
Identifiers
AliasesSLC22A11, OAT4, hOAT4, solute carrier family 22 member 11
External IDsOMIM: 607097 HomoloGene: 81863 GeneCards: SLC22A11
Orthologs
SpeciesHumanMouse
Entrez

55867

n/a

Ensembl

ENSG00000168065

n/a

UniProt

Q9NSA0

n/a

RefSeq (mRNA)

NM_001307985
NM_018484

n/a

RefSeq (protein)

NP_001294914
NP_060954

n/a

Location (UCSC)Chr 11: 64.56 – 64.57 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.[6]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168065 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi:10.1074/jbc.275.6.4507. PMID 10660625.
  4. ^ Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633. S2CID 7477352.
  5. ^ Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi:10.1681/ASN.2006040415. PMID 17229912.
  6. ^ a b "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

Further reading edit

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.
  • Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.
  • Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID 11907186. S2CID 7739298.
  • Takeda M, Babu E, Narikawa S, Endou H (2002). "Interaction of human organic anion transporters with various cephalosporin antibiotics". Eur. J. Pharmacol. 438 (3): 137–42. doi:10.1016/S0014-2999(02)01306-7. PMID 11909604.
  • Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID 12023506.
  • Enomoto A, Kimura H, Chairoungdua A, et al. (2002). "Molecular identification of a renal urate anion exchanger that regulates blood urate levels". Nature. 417 (6887): 447–52. Bibcode:2002Natur.417..447E. doi:10.1038/nature742. PMID 12024214. S2CID 4417844.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhou F, Tanaka K, Pan Z, et al. (2004). "The role of glycine residues in the function of human organic anion transporter 4". Mol. Pharmacol. 65 (5): 1141–7. doi:10.1124/mol.65.5.1141. PMID 15102942.
  • Zhou F, Pan Z, Ma J, You G (2005). "Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)". Biochem. J. 384 (Pt 1): 87–92. doi:10.1042/BJ20040751. PMC 1134091. PMID 15291761.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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April 10, 2024
slc22a11, solute, carrier, family, member, protein, that, humans, encoded, gene, identifiersaliases, oat4, hoat4, solute, carrier, family, member, 11external, idsomim, 607097, homologene, 81863, genecards, gene, location, human, chromosome, human, band11q13, 1. Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene 3 4 5 6 SLC22A11IdentifiersAliasesSLC22A11 OAT4 hOAT4 solute carrier family 22 member 11External IDsOMIM 607097 HomoloGene 81863 GeneCards SLC22A11Gene location Human Chr Chromosome 11 human 1 Band11q13 1Start64 555 690 bp 1 End64 572 875 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inkidneyplacentakidney tubulemetanephric glomeruluscorpus epididymiscaput epididymisrenal medullaliverright lobe of liversural nerven aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionorganic anion transmembrane transporter activity protein binding inorganic anion exchanger activity transmembrane transporter activity sodium independent organic anion transmembrane transporter activity urate transmembrane transporter activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane extracellular exosome apical plasma membrane external side of plasma membrane membraneBiological processsodium independent organic anion transport ion transport urate metabolic process organic anion transport transmembrane transport inorganic anion transport urate transport organic acid transmembrane transport transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez55867n aEnsemblENSG00000168065n aUniProtQ9NSA0n aRefSeq mRNA NM 001307985NM 018484n aRefSeq protein NP 001294914NP 060954n aLocation UCSC Chr 11 64 56 64 57 Mbn aPubMed search 2 n aWikidataView Edit HumanThe protein encoded by this gene is involved in the sodium independent transport and excretion of organic anions some of which are potentially toxic The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta where it may act to prevent potentially harmful organic anions from reaching the fetus 6 See also editSolute carrier familyReferences edit a b c GRCh38 Ensembl release 89 ENSG00000168065 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cha SH Sekine T Kusuhara H Yu E Kim JY Kim DK Sugiyama Y Kanai Y Endou H Mar 2000 Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta J Biol Chem 275 6 4507 12 doi 10 1074 jbc 275 6 4507 PMID 10660625 Zhou F Xu W Hong M Pan Z Sinko PJ Ma J You G Feb 2005 The role of N linked glycosylation in protein folding membrane targeting and substrate binding of human organic anion transporter hOAT4 Mol Pharmacol 67 3 868 76 doi 10 1124 mol 104 007583 PMID 15576633 S2CID 7477352 Hagos Y Stein D Ugele B Burckhardt G Bahn A Jan 2007 Human renal organic anion transporter 4 operates as an asymmetric urate transporter J Am Soc Nephrol 18 2 430 9 doi 10 1681 ASN 2006040415 PMID 17229912 a b Entrez Gene SLC22A11 solute carrier family 22 organic anion cation transporter member 11 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Sun W Wu RR van Poelje PD Erion MD 2001 Isolation of a family of organic anion transporters from human liver and kidney Biochem Biophys Res Commun 283 2 417 22 doi 10 1006 bbrc 2001 4774 PMID 11327718 Babu E Takeda M Narikawa S et al 2002 Human organic anion transporters mediate the transport of tetracycline Jpn J Pharmacol 88 1 69 76 doi 10 1254 jjp 88 69 PMID 11855680 Kimura H Takeda M Narikawa S et al 2002 Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins J Pharmacol Exp Ther 301 1 293 8 doi 10 1124 jpet 301 1 293 PMID 11907186 S2CID 7739298 Takeda M Babu E Narikawa S Endou H 2002 Interaction of human organic anion transporters with various cephalosporin antibiotics Eur J Pharmacol 438 3 137 42 doi 10 1016 S0014 2999 02 01306 7 PMID 11909604 Enomoto A Takeda M Shimoda M et al 2002 Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors J Pharmacol Exp Ther 301 3 797 802 doi 10 1124 jpet 301 3 797 PMID 12023506 Enomoto A Kimura H Chairoungdua A et al 2002 Molecular identification of a renal urate anion exchanger that regulates blood urate levels Nature 417 6887 447 52 Bibcode 2002Natur 417 447E doi 10 1038 nature742 PMID 12024214 S2CID 4417844 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Zhou F Tanaka K Pan Z et al 2004 The role of glycine residues in the function of human organic anion transporter 4 Mol Pharmacol 65 5 1141 7 doi 10 1124 mol 65 5 1141 PMID 15102942 Zhou F Pan Z Ma J You G 2005 Mutational analysis of histidine residues in human organic anion transporter 4 hOAT4 Biochem J 384 Pt 1 87 92 doi 10 1042 BJ20040751 PMC 1134091 PMID 15291761 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Taylor TD Noguchi H Totoki Y et al 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification Nature 440 7083 497 500 Bibcode 2006Natur 440 497T doi 10 1038 nature04632 PMID 16554811 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title SLC22A11 amp oldid 1142720757, wikipedia, wiki, book, books, library,

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