Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.[2]: 856 It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[3]
reticular, pigmented, anomaly, flexures, also, known, dark, disease, dowling, degos, disease, fibrous, anomaly, flexures, bending, parts, axillae, neck, inframammary, sternal, areas, autosomal, dominant, pigmentary, disorder, that, appear, adolescence, adultho. Reticular pigmented anomaly of the flexures also known as dark dot disease and Dowling Degos disease is a fibrous anomaly of the flexures or bending parts of the axillae neck and inframammary sternal areas 2 856 It is an autosomal dominant pigmentary disorder that may appear in adolescence or adulthood This condition is due to mutations in structural desmosomal proteins found within stratified squamous epithelium 3 Reticular pigmented anomaly of the flexuresOther namesKitamura reticulate acropigmentation 1 SpecialtyDermatology Dark dot disease is associated with KRT5 4 See also editList of cutaneous conditions List of cutaneous conditions caused by mutations in keratins Skin lesionReferences edit Dowling Degos disease Genetic and Rare Diseases Information Center GARD an NCATS Program rarediseases info nih gov Retrieved 23 April 2019 James William Berger Timothy Elston Dirk 2005 Andrews Diseases of the Skin Clinical Dermatology 10th ed Saunders ISBN 0 7216 2921 0 Rapini Ronald P Bolognia Jean L Jorizzo Joseph L 2007 Dermatology 2 Volume Set St Louis Mosby ISBN 978 1 4160 2999 1 Betz RC Planko L Eigelshoven S et al March 2006 Loss of function mutations in the keratin 5 gene lead to Dowling Degos disease Am J Hum Genet 78 3 510 9 doi 10 1086 500850 PMC 1380294 PMID 16465624 External links edit nbsp This cutaneous condition article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Reticular pigmented anomaly of the flexures amp oldid 1035360555, wikipedia, wiki, book, books, library,
