Respiratory bronchiolitis is a lung disease associated with tobacco smoking.[1] In pathology, it is defined by the presence of "smoker's macrophages".[1] When manifesting significant clinical symptoms it is referred to as respiratory bronchiolitis interstitial lung disease (RB-ILD).[1]
Respiratory bronchiolitis
Other names
RB-ILD
A "smoker's macrophage", with yellow to light brown and finely granular cytoplasmic pigment.
Pathologic: Lung biopsy with "smoker's macrophages" limited to distal airspaces and peribronchiolar airspaces, and minimal to absent peribronchiolar interstitial fibrotic thickening
It is a histological finding, not a pathological description. When associated with disease, it is known as "Respiratory bronchiolitis-associated interstitial lung disease" or "RB-ILD".[4] Also, this disease is predominantly found in the upper lobe with centrilobar ground glass nodules. Importantly, no fibrosis is involved, just bronchial wall thickening. Treatment is to stop smoking.
^ abcdeWilliam Perry, M.D., M.P.H., Kristine Konopka, M.D. "Respiratory bronchiolitis". Pathology Outlines.{{cite web}}: CS1 maint: multiple names: authors list (link) Topic Completed: 1 July 2020. Minor changes: 1 July 2020
^Sousa, Célia; Rodrigues, Márcio; Carvalho, André; Viamonte, Bárbara; Cunha, Rui; Guimarães, Susana; de Moura, Conceição Souto; Morais, António; Pereira, José Miguel (2019). "Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation". Insights into Imaging. 10 (1): 73. doi:10.1186/s13244-019-0765-z. ISSN 1869-4101. PMC6635572. PMID 31312909. - This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
^Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 741. ISBN0-7216-0187-1.
^Heyneman LE, Ward S, Lynch DA, Remy-Jardin M, Johkoh T, Müller NL (December 1999). "Respiratory bronchiolitis, respiratory bronchiolitis-associated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?". AJR Am J Roentgenol. 173 (6): 1617–22. doi:10.2214/ajr.173.6.10584810. PMID 10584810.
External linksedit
December 15, 2023
respiratory, bronchiolitis, lung, disease, associated, with, tobacco, smoking, pathology, defined, presence, smoker, macrophages, when, manifesting, significant, clinical, symptoms, referred, respiratory, bronchiolitis, interstitial, lung, disease, other, name. Respiratory bronchiolitis is a lung disease associated with tobacco smoking 1 In pathology it is defined by the presence of smoker s macrophages 1 When manifesting significant clinical symptoms it is referred to as respiratory bronchiolitis interstitial lung disease RB ILD 1 Respiratory bronchiolitisOther namesRB ILDA smoker s macrophage with yellow to light brown and finely granular cytoplasmic pigment SpecialtyPulmonology Contents 1 Diagnosis 2 Respiratory bronchiolitis interstitial lung disease 3 See also 4 References 5 External linksDiagnosis edit nbsp Histopathology of respiratory bronchiolitis Smoker s macrophages arrow mild interstitial lymphocytic infiltrate and mild fibrosis arrowhead 2 Diagnosis of respiratory bronchiolitis requires a correlation of clinical radiologic and pathologic findings 1 Clinical Symptoms and pulmonary function testing Radiologic Chest radiograph and high resolution computed tomography Pathologic Lung biopsy with smoker s macrophages limited to distal airspaces and peribronchiolar airspaces and minimal to absent peribronchiolar interstitial fibrotic thickeningRespiratory bronchiolitis interstitial lung disease edit nbsp Histopathology of smoker s macrophages with anthracotic stippling indicating the presence of both respiratory bronchiolitis and anthracosis Respiratory bronchiolitis interstitial lung disease is respiratory bronchiolitis that manifests as a clinically significant interstitial lung disease 1 It is a form of idiopathic interstitial pneumonia associated with smoking 3 It is a histological finding not a pathological description When associated with disease it is known as Respiratory bronchiolitis associated interstitial lung disease or RB ILD 4 Also this disease is predominantly found in the upper lobe with centrilobar ground glass nodules Importantly no fibrosis is involved just bronchial wall thickening Treatment is to stop smoking The appearance is similar to desquamative interstitial pneumonia and some have suggested that the two conditions are caused by the same processes 5 See also editBronchiolitisReferences edit a b c d e William Perry M D M P H Kristine Konopka M D Respiratory bronchiolitis Pathology Outlines a href Template Cite web html title Template Cite web cite web a CS1 maint multiple names authors list link Topic Completed 1 July 2020 Minor changes 1 July 2020 Sousa Celia Rodrigues Marcio Carvalho Andre Viamonte Barbara Cunha Rui Guimaraes Susana de Moura Conceicao Souto Morais Antonio Pereira Jose Miguel 2019 Diffuse smoking related lung diseases insights from a radiologic pathologic correlation Insights into Imaging 10 1 73 doi 10 1186 s13244 019 0765 z ISSN 1869 4101 PMC 6635572 PMID 31312909 This article is distributed under the terms of the Creative Commons Attribution 4 0 International License http creativecommons org licenses by 4 0 Idiopathic Interstitial Pneumonias Interstitial Lung Diseases Merck Manual Professional Retrieved 2008 12 09 Cotran Ramzi S Kumar Vinay Fausto Nelson Nelso Fausto Robbins Stanley L Abbas Abul K 2005 Robbins and Cotran pathologic basis of disease St Louis Mo Elsevier Saunders p 741 ISBN 0 7216 0187 1 Heyneman LE Ward S Lynch DA Remy Jardin M Johkoh T Muller NL December 1999 Respiratory bronchiolitis respiratory bronchiolitis associated interstitial lung disease and desquamative interstitial pneumonia different entities or part of the spectrum of the same disease process AJR Am J Roentgenol 173 6 1617 22 doi 10 2214 ajr 173 6 10584810 PMID 10584810 External links edit Retrieved from https en wikipedia org w index php title Respiratory bronchiolitis amp oldid 1183568237, wikipedia, wiki, book, books, library,
