Rakesh K. Jain (born 1950) is the Andrew Werk Cook Professor of Tumor Biology at Massachusetts General Hospital in the Harvard Medical School and director of the E.L. Steele Laboratories for Tumor Biology at the Massachusetts General Hospital. [1]
He has mentored more than 200 graduate and postdoctoral students from over a dozen different disciplines. Jain's research findings are summarized in more than 600 publications, which have been cited more than 200,000 times (as of November, 2023). He was among the top 1% cited researchers in Clinical Medicine in 2014-15.[2] He serves or has served on advisory panels to government, industry and academia, and is a member of editorial advisory boards of 22 journals, including Nature Reviews Cancer and Nature Reviews Clinical Oncology.
He has received more than 75 awards from engineering and medical professional societies/institutions. He was elected a member of the National Academy of Engineering in 2004 for the integration of bioengineering with tumor biology and imaging gene expression and functions in vivo for drug delivery in tumors. He is also a member of the National Academy of Medicine, the National Academy of Sciences and the American Academy of Arts and Sciences. In 2014, he was chosen as one of 50 Oncology Luminaries on the occasion of the 50th anniversary of the American Society of Clinical Oncology.[3] In 2015, Jain received honorary doctorates from Duke University, KU Leuven, Belgium and IIT-Kanpur, India. In 2013, he was awarded the National Medal of Science.[4]
Jain received his bachelor's degree in 1972 from IIT Kanpur, and his MS and PhD degrees in 1974 and 1976 from the University of Delaware, all in chemical engineering. He served as assistant professor of chemical engineering at Columbia University (1976 to 1978), and as assistant (1978–79), associate (1979–83) and full professor (1983-1991) of chemical engineering at Carnegie Mellon University. He spent his 1983-84 sabbatical year as a Guggenheim Fellow in the departments of chemical engineering at MIT, bioengineering at UCSD and radiation oncology at Stanford, and his 1990-91 sabbatical as a Humboldt Senior Scientist-Awardee at the Institute of Pathophysiology of University of Mainz, and the Institute of Experimental Surgery of University of Munich. In 1991, Jain became the Andrew Werk Cook Professor of Radiation Oncology (Tumor Biology) at Harvard Medical School, and Director of Edwin L. Steele Laboratories of Tumor Biology at Massachusetts General Hospital.
Researchedit
Jain is regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology, drug delivery, in vivo imaging, bioengineering, and bench-to-bedside translation.[5][6][7][8] These include uncovering the barriers to the delivery and efficacy of molecular and nano-medicines in tumors, developing new strategies to overcome these barriers, and then translating these strategies from bench to bedside.[9][10] He is most celebrated for proposing a new principle – normalization of vasculature – for treatment of malignant and non-malignant diseases characterized by abnormal vessels that afflict more than 500 million people worldwide.[11][12][13] This concept has fundamentally changed the thinking of scientists and clinicians about how antiangiogenic agents work, and how to combine them optimally with other therapies to improve the treatment outcome in patients.[3]
^Jain, RK. An indirect way to tame cancer. Sci Am, 310: 46-53, 2014
^Jain, RK and PF Carmeliet. Vessels of death or life. Sci Am, 285: 38-45, 2001
^Jain, RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol, 31: 2205-18, 2013
^Video of the award lecture, Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers; 2012 ASCO Annual Meeting
^Jain, RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell, 26: 605-22, 2014
^Jain, RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med, 7: 987-9, 2001
^Jain, RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 307: 58-62, 2005
External linksedit
Curriculum Vitae at Harvard Medical School
May 13, 2024
rakesh, jain, rakesh, jain, born, 1950, andrew, werk, cook, professor, tumor, biology, massachusetts, general, hospital, harvard, medical, school, director, steele, laboratories, tumor, biology, massachusetts, general, hospital, rakesh, jainborndecember, 1950a. Rakesh K Jain born 1950 is the Andrew Werk Cook Professor of Tumor Biology at Massachusetts General Hospital in the Harvard Medical School and director of the E L Steele Laboratories for Tumor Biology at the Massachusetts General Hospital 1 Rakesh K JainBornDecember 18 1950Alma materUniversity of Delaware Indian Institute of Technology KanpurKnown forTumor pathophysiology Tumor normalizationAwardsGuggenheim Fellowship 1983 Founding Fellow American Institute for Medical and Biological Engineering 1992 Outstanding Investigator Grant NIH 1993 2015 Whitaker Distinguished Lecturer Biomedical Engineering Society 1995 Eugene M Landis Award Microcirculatory Society 1996 National Academy of Medicine 2003 National Academy of Engineering 2004 Academic Scientist of the Year 2005 Pharmaceutical Achievement Awards 2005 Benjamin Zweifach Distinguished Lecture The City College New York 2006 Elected to American Academy of Arts and Sciences 2008 National Academy of Sciences 2009 ASCO Science of Oncology Award and Lecture 2012 Princess Takamatsu Lecture Award National Medal of Science 2013 American Association for Cancer Research 2014 Earl P Benditt Award 2018 Scientific careerFieldsChemical Engineering Bioengineering Tumor BiologyInstitutionsHarvard Medical School Massachusetts General HospitalDoctoral advisorJames WeiOther academic advisorsPietro M Gullino He has mentored more than 200 graduate and postdoctoral students from over a dozen different disciplines Jain s research findings are summarized in more than 600 publications which have been cited more than 200 000 times as of November 2023 He was among the top 1 cited researchers in Clinical Medicine in 2014 15 2 He serves or has served on advisory panels to government industry and academia and is a member of editorial advisory boards of 22 journals including Nature Reviews Cancer and Nature Reviews Clinical Oncology He has received more than 75 awards from engineering and medical professional societies institutions He was elected a member of the National Academy of Engineering in 2004 for the integration of bioengineering with tumor biology and imaging gene expression and functions in vivo for drug delivery in tumors He is also a member of the National Academy of Medicine the National Academy of Sciences and the American Academy of Arts and Sciences In 2014 he was chosen as one of 50 Oncology Luminaries on the occasion of the 50th anniversary of the American Society of Clinical Oncology 3 In 2015 Jain received honorary doctorates from Duke University KU Leuven Belgium and IIT Kanpur India In 2013 he was awarded the National Medal of Science 4 Contents 1 Training and career path 2 Research 3 References 4 External linksTraining and career path editJain received his bachelor s degree in 1972 from IIT Kanpur and his MS and PhD degrees in 1974 and 1976 from the University of Delaware all in chemical engineering He served as assistant professor of chemical engineering at Columbia University 1976 to 1978 and as assistant 1978 79 associate 1979 83 and full professor 1983 1991 of chemical engineering at Carnegie Mellon University He spent his 1983 84 sabbatical year as a Guggenheim Fellow in the departments of chemical engineering at MIT bioengineering at UCSD and radiation oncology at Stanford and his 1990 91 sabbatical as a Humboldt Senior Scientist Awardee at the Institute of Pathophysiology of University of Mainz and the Institute of Experimental Surgery of University of Munich In 1991 Jain became the Andrew Werk Cook Professor of Radiation Oncology Tumor Biology at Harvard Medical School and Director of Edwin L Steele Laboratories of Tumor Biology at Massachusetts General Hospital Research editJain is regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology drug delivery in vivo imaging bioengineering and bench to bedside translation 5 6 7 8 These include uncovering the barriers to the delivery and efficacy of molecular and nano medicines in tumors developing new strategies to overcome these barriers and then translating these strategies from bench to bedside 9 10 He is most celebrated for proposing a new principle normalization of vasculature for treatment of malignant and non malignant diseases characterized by abnormal vessels that afflict more than 500 million people worldwide 11 12 13 This concept has fundamentally changed the thinking of scientists and clinicians about how antiangiogenic agents work and how to combine them optimally with other therapies to improve the treatment outcome in patients 3 References edit Steele Laboratories web site Thomson Reuters list of highly cited researchers a b ASCO Post August 15 2014 Vol 5 Issue 13 National Science amp Technology Medals Foundation Jain RK Barriers to drug delivery in solid tumors Sci Am 271 58 65 1994 Jain RK Taming vessels to treat cancer Sci Am 298 56 63 2008 Jain RK An indirect way to tame cancer Sci Am 310 46 53 2014 Jain RK and PF Carmeliet Vessels of death or life Sci Am 285 38 45 2001 Jain RK Normalizing tumor microenvironment to treat cancer bench to bedside to biomarkers J Clin Oncol 31 2205 18 2013 Video of the award lecture Normalizing Tumor Microenvironment to Treat Cancer Bench to Bedside to Biomarkers 2012 ASCO Annual Meeting Jain RK Antiangiogenesis strategies revisited from starving tumors to alleviating hypoxia Cancer Cell 26 605 22 2014 Jain RK Normalizing tumor vasculature with anti angiogenic therapy a new paradigm for combination therapy Nat Med 7 987 9 2001 Jain RK Normalization of tumor vasculature an emerging concept in antiangiogenic therapy Science 307 58 62 2005External links editCurriculum Vitae at Harvard Medical School Retrieved from https en wikipedia org w index php title Rakesh Jain amp oldid 1223418594, wikipedia, wiki, book, books, library,
