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Wikipedia

RARRES3

January 01, 1970

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.[3][4]

PLAAT4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPLAAT4, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3, retinoic acid receptor responder 3, PLAAT-4, RARRES3, phospholipase A and acyltransferase 4
External IDsOMIM: 605092 HomoloGene: 48290 GeneCards: PLAAT4
Orthologs
SpeciesHumanMouse
Entrez

5920

n/a

Ensembl

ENSG00000133321

n/a

UniProt

Q9UL19

n/a

RefSeq (mRNA)

NM_004585

n/a

RefSeq (protein)

NP_004576

n/a

Location (UCSC)Chr 11: 63.54 – 63.55 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.[4]

Interactions edit

RARRES3 has been shown to interact with RNF135.[5]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133321 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
  4. ^ a b "Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3".
  5. ^ Oshiumi, Hiroyuki; Matsumoto Misako; Hatakeyama Shigetsugu; Seya Tsukasa (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J. Biol. Chem. 284 (2). United States: 807–17. doi:10.1074/jbc.M804259200. ISSN 0021-9258. PMID 19017631.

Further reading edit

  • Nagpal S, Patel S, Jacobe H, et al. (1997). "Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin". J. Invest. Dermatol. 109 (1): 91–5. doi:10.1111/1523-1747.ep12276660. PMID 9204961.
  • DiSepio D, Ghosn C, Eckert RL, et al. (1999). "Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14811–5. Bibcode:1998PNAS...9514811D. doi:10.1073/pnas.95.25.14811. PMC 24531. PMID 9843971.
  • Huang SL, Shyu RY, Yeh MY, Jiang SY (2000). "Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells". Mol. Cell. Endocrinol. 159 (1–2): 15–24. doi:10.1016/S0303-7207(99)00207-5. PMID 10687848. S2CID 11139637.
  • Duvic M, Helekar B, Schulz C, et al. (2000). "Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer". Clin. Cancer Res. 6 (8): 3249–59. PMID 10955811.
  • Deucher A, Nagpal S, Chandraratna RA, et al. (2001). "The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity". Int. J. Oncol. 17 (6): 1195–203. doi:10.3892/ijo.17.6.1195. PMID 11078805.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Higuchi E, Chandraratna RA, Hong WK, Lotan R (2003). "Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype". Oncogene. 22 (30): 4627–35. doi:10.1038/sj.onc.1206235. PMID 12879006. S2CID 20142546.
  • Sturniolo MT, Dashti SR, Deucher A, et al. (2004). "A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase". J. Biol. Chem. 278 (48): 48066–73. doi:10.1074/jbc.M307215200. PMID 12928434.
  • Yoneyama M, Kikuchi M, Natsukawa T, et al. (2004). "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses". Nat. Immunol. 5 (7): 730–7. doi:10.1038/ni1087. PMID 15208624. S2CID 34876422.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jiang SY, Chou JM, Leu FJ, et al. (2005). "Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma". World J. Gastroenterol. 11 (7): 948–53. doi:10.3748/wjg.v11.i7.948. PMC 4250783. PMID 15742394.
  • Sturniolo MT, Chandraratna RA, Eckert RL (2005). "A novel transglutaminase activator forms a complex with type 1 transglutaminase". Oncogene. 24 (18): 2963–72. doi:10.1038/sj.onc.1208392. PMID 15846304.
  • Jiang SY, Wu MS, Chen LM, et al. (2005). "Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter". Biochem. Biophys. Res. Commun. 331 (2): 630–9. doi:10.1016/j.bbrc.2005.03.214. PMID 15850806.
  • Lotz K, Kellner T, Heitmann M, et al. (2005). "Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms". Int. J. Cancer. 116 (6): 894–902. doi:10.1002/ijc.21127. PMID 15856468. S2CID 19064264.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Guo Z, Chen LM, Zeng H, et al. (2007). "NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I". Am. J. Respir. Cell Mol. Biol. 36 (3): 263–9. doi:10.1165/rcmb.2006-0283RC. PMID 17053203.
  • Chen Z, Benureau Y, Rijnbrand R, et al. (2007). "GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS". J. Virol. 81 (2): 964–76. doi:10.1128/JVI.02076-06. PMC 1797450. PMID 17093192.
  • Tsai FM, Shyu RY, Jiang SY (2007). "RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus". Cell. Signal. 19 (5): 989–99. doi:10.1016/j.cellsig.2006.11.005. PMID 17196792.
 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
rarres3, retinoic, acid, receptor, responder, protein, protein, that, humans, encoded, gene, plaat4available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes2lkt, 2my9identifiersaliasesplaat4, hrasls4, hrsl4, pla1, rig1, tig3, retinoic, acid, recept. Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene 3 4 PLAAT4Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes2LKT 2MY9IdentifiersAliasesPLAAT4 HRASLS4 HRSL4 PLA1 2 3 RIG1 TIG3 retinoic acid receptor responder 3 PLAAT 4 RARRES3 phospholipase A and acyltransferase 4External IDsOMIM 605092 HomoloGene 48290 GeneCards PLAAT4Gene location Human Chr Chromosome 11 human 1 Band11q12 3Start63 536 808 bp 1 End63 546 462 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inpalpebral conjunctivabronchial epithelial cellupper lobe of left lungright uterine tubelymph noderight lungduodenumgallbladderjejunal mucosamonocyten aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding hydrolase activity phospholipase A2 activity acyltransferase activity phospholipase A1 activity N acyltransferase activity phosphatidylserine 1 acylhydrolase activity 1 acyl 2 lysophosphatidylserine acylhydrolase activityCellular componentintegral component of membrane membrane cytosolBiological processlipid catabolic process lipid metabolism negative regulation of cell population proliferation phospholipid metabolic process phosphatidylethanolamine acyl chain remodeling N acylphosphatidylethanolamine metabolic process positive regulation of keratinocyte differentiation positive regulation of protein glutamine gamma glutamyltransferase activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5920n aEnsemblENSG00000133321n aUniProtQ9UL19n aRefSeq mRNA NM 004585n aRefSeq protein NP 004576n aLocation UCSC Chr 11 63 54 63 55 Mbn aPubMed search 2 n aWikidataView Edit Human Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators RARRES1 RARRES2 and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene RARRES3 is thought act as a tumor suppressor or growth regulator 4 Interactions editRARRES3 has been shown to interact with RNF135 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000133321 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Duvic M Nagpal S Asano AT Chandraratna RA Sep 1997 Molecular mechanisms of tazarotene action in psoriasis J Am Acad Dermatol 37 2 Pt 3 S18 24 doi 10 1016 s0190 9622 97 80396 9 PMID 9270552 a b Entrez Gene RARRES3 retinoic acid receptor responder tazarotene induced 3 Oshiumi Hiroyuki Matsumoto Misako Hatakeyama Shigetsugu Seya Tsukasa Jan 2009 Riplet RNF135 a RING finger protein ubiquitinates RIG I to promote interferon beta induction during the early phase of viral infection J Biol Chem 284 2 United States 807 17 doi 10 1074 jbc M804259200 ISSN 0021 9258 PMID 19017631 Further reading editNagpal S Patel S Jacobe H et al 1997 Tazarotene induced gene 2 TIG2 a novel retinoid responsive gene in skin J Invest Dermatol 109 1 91 5 doi 10 1111 1523 1747 ep12276660 PMID 9204961 DiSepio D Ghosn C Eckert RL et al 1999 Identification and characterization of a retinoid induced class II tumor suppressor growth regulatory gene Proc Natl Acad Sci U S A 95 25 14811 5 Bibcode 1998PNAS 9514811D doi 10 1073 pnas 95 25 14811 PMC 24531 PMID 9843971 Huang SL Shyu RY Yeh MY Jiang SY 2000 Cloning and characterization of a novel retinoid inducible gene 1 RIG1 deriving from human gastric cancer cells Mol Cell Endocrinol 159 1 2 15 24 doi 10 1016 S0303 7207 99 00207 5 PMID 10687848 S2CID 11139637 Duvic M Helekar B Schulz C et al 2000 Expression of a retinoid inducible tumor suppressor Tazarotene inducible gene 3 is decreased in psoriasis and skin cancer Clin Cancer Res 6 8 3249 59 PMID 10955811 Deucher A Nagpal S Chandraratna RA et al 2001 The carboxy terminal hydrophobic domain of TIG3 a class II tumor suppressor protein is required for appropriate cellular localization and optimal biological activity Int J Oncol 17 6 1195 203 doi 10 3892 ijo 17 6 1195 PMID 11078805 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Higuchi E Chandraratna RA Hong WK Lotan R 2003 Induction of TIG3 a putative class II tumor suppressor gene by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype Oncogene 22 30 4627 35 doi 10 1038 sj onc 1206235 PMID 12879006 S2CID 20142546 Sturniolo MT Dashti SR Deucher A et al 2004 A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase J Biol Chem 278 48 48066 73 doi 10 1074 jbc M307215200 PMID 12928434 Yoneyama M Kikuchi M Natsukawa T et al 2004 The RNA helicase RIG I has an essential function in double stranded RNA induced innate antiviral responses Nat Immunol 5 7 730 7 doi 10 1038 ni1087 PMID 15208624 S2CID 34876422 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Jiang SY Chou JM Leu FJ et al 2005 Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma World J Gastroenterol 11 7 948 53 doi 10 3748 wjg v11 i7 948 PMC 4250783 PMID 15742394 Sturniolo MT Chandraratna RA Eckert RL 2005 A novel transglutaminase activator forms a complex with type 1 transglutaminase Oncogene 24 18 2963 72 doi 10 1038 sj onc 1208392 PMID 15846304 Jiang SY Wu MS Chen LM et al 2005 Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter Biochem Biophys Res Commun 331 2 630 9 doi 10 1016 j bbrc 2005 03 214 PMID 15850806 Lotz K Kellner T Heitmann M et al 2005 Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen activated kinase dependent and independent mechanisms Int J Cancer 116 6 894 902 doi 10 1002 ijc 21127 PMID 15856468 S2CID 19064264 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Guo Z Chen LM Zeng H et al 2007 NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor RIG I Am J Respir Cell Mol Biol 36 3 263 9 doi 10 1165 rcmb 2006 0283RC PMID 17053203 Chen Z Benureau Y Rijnbrand R et al 2007 GB virus B disrupts RIG I signaling by NS3 4A mediated cleavage of the adaptor protein MAVS J Virol 81 2 964 76 doi 10 1128 JVI 02076 06 PMC 1797450 PMID 17093192 Tsai FM Shyu RY Jiang SY 2007 RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus Cell Signal 19 5 989 99 doi 10 1016 j cellsig 2006 11 005 PMID 17196792 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title RARRES3 amp oldid 1174278046, wikipedia, wiki, book, books, library,

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