The R1 Plasmid is a plasmid that was first isolated from Salmonella paratyphibacteria in 1963.[1] It is a short plasmid, composed of 97,566 nucleotides and 120 genes, that belongs to the IncFII plasmid group.[2]
Figure 1. Map of the R1 Plasmid isolated by Katherine E. L. Cox and Joel F. Schildbach.
It's known as a "low copy" plasmid, meaning that it exists in relatively few copies in any given bacteria. This characteristic allows the R1 plasmid to have an efficient plasmid stabilization system, that aids in stabilizing medium copy number plasmids.[4] R1 must rely on "Type II" segregation system. This plasmid system ensures that at least one copy is contained in each daughter cell after cell division.
Partitioning System
The R1 plasmid partitioning is a mechanism needed for the inheritance of the R1 plasmid. The par system is composed of the ParR and the parC regions, that interact together. The par system determines the position of the replicon, ensuring that at the end of DNA Replication, the plasmid copies are well-positioned to start cell division. The par system also allows for the initiation of ParM formation. ParM produces two important cytoskeletal proteins, MreB, and actin. ParM is directed to move the plasmid copies to opposite cell poles. Cell division takes place, resulting in the partitioned plasmids in two daughter cells.[5]
Some genes on the R1 plasmid are:
ParM is a prokaryotic actin homologue which provides the force to drive copies of the R1 plasmid to opposite ends of rod shaped bacteria before division.
The Hok/sok system a post-segregational killing system of the plasmid.
CopA-like RNA, an antisense RNA involved in replication control of the plasmid.
References
^N. Datta & P. Kontomichalou, Nature 208 (1965) 239-241.
plasmid, plasmid, plasmid, that, first, isolated, from, salmonella, paratyphi, bacteria, 1963, short, plasmid, composed, nucleotides, genes, that, belongs, incfii, plasmid, group, figure, plasmid, isolated, katherine, joel, schildbach, imparts, multi, drug, an. The R1 Plasmid is a plasmid that was first isolated from Salmonella paratyphi bacteria in 1963 1 It is a short plasmid composed of 97 566 nucleotides and 120 genes that belongs to the IncFII plasmid group 2 Figure 1 Map of the R1 Plasmid isolated by Katherine E L Cox and Joel F Schildbach The R1 plasmid imparts multi drug antibiotic resistance to its host bacteria 3 It s known as a low copy plasmid meaning that it exists in relatively few copies in any given bacteria This characteristic allows the R1 plasmid to have an efficient plasmid stabilization system that aids in stabilizing medium copy number plasmids 4 R1 must rely on Type II segregation system This plasmid system ensures that at least one copy is contained in each daughter cell after cell division Partitioning System EditThe R1 plasmid partitioning is a mechanism needed for the inheritance of the R1 plasmid The par system is composed of the ParR and the parC regions that interact together The par system determines the position of the replicon ensuring that at the end of DNA Replication the plasmid copies are well positioned to start cell division The par system also allows for the initiation of ParM formation ParM produces two important cytoskeletal proteins MreB and actin ParM is directed to move the plasmid copies to opposite cell poles Cell division takes place resulting in the partitioned plasmids in two daughter cells 5 Some genes on the R1 plasmid are ParM is a prokaryotic actin homologue which provides the force to drive copies of the R1 plasmid to opposite ends of rod shaped bacteria before division The Hok sok system a post segregational killing system of the plasmid CopA like RNA an antisense RNA involved in replication control of the plasmid References Edit N Datta amp P Kontomichalou Nature 208 1965 239 241 Nordstrom K Plasmid 2006 1 26 C S Campbell and R D Mullins Journal of Cell Biology 179 2007 1059 Biopharmaceutical production technology Subramanian G 1935 Weinheim Wiley VCH 2012 ISBN 978 3 527 65312 6 OCLC 794328715 a href Template Cite book html title Template Cite book cite book a CS1 maint others link Moller Jensen Jakob Borch Jonas Dam Mette Jensen Rasmus B Roepstorff Peter Gerdes Kenn 2003 12 01 Bacterial Mitosis ParM of Plasmid R1 Moves Plasmid DNA by an Actin like Insertional Polymerization Mechanism Molecular Cell 12 6 1477 1487 doi 10 1016 S1097 2765 03 00451 9 ISSN 1097 2765 PMID 14690601 This cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title R1 plasmid amp oldid 1136798192, wikipedia, wiki, book, books, library,
