This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glutathione:protein-disulfide oxidoreductase. Other names in common use include glutathione-insulin transhydrogenase, insulin reductase, reductase, protein disulfide (glutathione), protein disulfide transhydrogenase, glutathione-protein disulfide oxidoreductase, protein disulfide reductase (glutathione), GSH-insulin transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, thiol:protein-disulfide oxidoreductase, and thiol-protein disulphide oxidoreductase. This enzyme participates in glutathione metabolism.
Structural studiesEdit
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2IJY.
ReferencesEdit
KATZEN HM, TIETZE F, STETTEN D (1963). "Further studies on the properties of hepatic glutathione-insulin transhydro-genase". J. Biol. Chem. 238: 1006–11. PMID 14031343.
Kohnert KD, Hahn HJ, Zuhlke H, Schmidt S, Fiedler H (1974). "Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro". Biochim. Biophys. Acta. 338: 68–77. doi:10.1016/0304-4165(74)90336-5.
protein, disulfide, reductase, glutathione, enzymology, protein, disulfide, reductase, glutathione, enzyme, that, catalyzes, chemical, reactionprotein, disulfide, reductase, glutathione, identifiersec, 2cas, 9082, 5databasesintenzintenz, viewbrendabrenda, entr. In enzymology a protein disulfide reductase glutathione EC 1 8 4 2 is an enzyme that catalyzes the chemical reactionprotein disulfide reductase glutathione IdentifiersEC no 1 8 4 2CAS no 9082 53 5DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins 2 glutathione protein disulfide displaystyle rightleftharpoons glutathione disulfide protein dithiolThus the two substrates of this enzyme are glutathione and protein disulfide whereas its two products are glutathione disulfide and protein dithiol This enzyme belongs to the family of oxidoreductases specifically those acting on a sulfur group of donors with a disulfide as acceptor The systematic name of this enzyme class is glutathione protein disulfide oxidoreductase Other names in common use include glutathione insulin transhydrogenase insulin reductase reductase protein disulfide glutathione protein disulfide transhydrogenase glutathione protein disulfide oxidoreductase protein disulfide reductase glutathione GSH insulin transhydrogenase protein disulfide interchange enzyme protein disulfide isomerase oxidoreductase thiol protein disulfide oxidoreductase and thiol protein disulphide oxidoreductase This enzyme participates in glutathione metabolism Structural studies EditAs of late 2007 only one structure has been solved for this class of enzymes with the PDB accession code 2IJY References EditKATZEN HM TIETZE F STETTEN D 1963 Further studies on the properties of hepatic glutathione insulin transhydro genase J Biol Chem 238 1006 11 PMID 14031343 Kohnert KD Hahn HJ Zuhlke H Schmidt S Fiedler H 1974 Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro Biochim Biophys Acta 338 68 77 doi 10 1016 0304 4165 74 90336 5 Portal Biology This EC 1 8 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Protein disulfide reductase glutathione amp oldid 918610085, wikipedia, wiki, book, books, library,
