PROSITE's uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. Properties from well-studied genes can be propagated to biologically related organisms, and for different or poorly known genes biochemical functions can be predicted from similarities. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif, PROSITE patterns). It is part of the ExPASyproteomics analysis servers.
The database ProRule builds on the domain descriptions of PROSITE.[3] It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
As of 26 February 2022[update], release 2022_01 has 1,902 documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 ProRules.
See alsoEdit
Uniprot — the universal protein database, a central resource on protein information - PROSITE adds data to it.
InterPro — a centralized database, grouping data from databases of protein families, domains and functional sites - part of the data come from PROSITE.
^De Castro E, Sigrist CJA, Gattiker A, Bulliard V, Langendijk-Genevaux PS, Gasteiger E, Bairoch A, Hulo N (2006). "ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins". Nucleic Acids Res. 34 (Web Server issue): W362–365. doi:10.1093/nar/gkl124. PMC1538847. PMID 16845026.
^Hulo N, Bairoch A, Bulliard V, Cerutti L, Cuche B, De Castro E, Lachaize C, Langendijk-Genevaux PS, Sigrist CJA (2007). "The 20 years of PROSITE". Nucleic Acids Res. 36 (Database issue): D245–9. doi:10.1093/nar/gkm977. PMC2238851. PMID 18003654.
^Sigrist CJ, De Castro E, Langendijk-Genevaux PS, Le Saux V, Bairoch A, Hulo N (2005). "ProRule: a new database containing functional and structural information on PROSITE profiles". Bioinformatics. 21 (21): 4060–4066. doi:10.1093/bioinformatics/bti614. PMID 16091411.
External linksEdit
Official website
ProRule — database of rules based on PROSITE predictors
September 13, 2023
prosite, protein, database, consists, entries, describing, protein, families, domains, functional, sites, well, amino, acid, patterns, profiles, them, these, manually, curated, team, swiss, institute, bioinformatics, tightly, integrated, into, swiss, prot, pro. PROSITE is a protein database 1 2 It consists of entries describing the protein families domains and functional sites as well as amino acid patterns and profiles in them These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss Prot protein annotation PROSITE was created in 1988 by Amos Bairoch who directed the group for more than 20 years Since July 2018 the director of PROSITE and Swiss Prot is Alan Bridge PROSITEContentDescriptionPROSITE a protein domain database for functional characterization and annotation ContactResearch centerSwiss Institute of BioinformaticsLaboratoryStructural Biology and Bioinformatics DepartmentPrimary citationPMID 19858104Release date1988 1988 AccessWebsiteprosite wbr expasy wbr orgPROSITE s uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity Properties from well studied genes can be propagated to biologically related organisms and for different or poorly known genes biochemical functions can be predicted from similarities PROSITE offers tools for protein sequence analysis and motif detection see sequence motif PROSITE patterns It is part of the ExPASy proteomics analysis servers The database ProRule builds on the domain descriptions of PROSITE 3 It provides additional information about functionally or structurally critical amino acids The rules contain information about biologically meaningful residues like active sites substrate or co factor binding sites posttranslational modification sites or disulfide bonds to help function determination These can automatically generate annotation based on PROSITE motifs Contents 1 Statistics 2 See also 3 References 4 External linksStatistics EditAs of 26 February 2022 update release 2022 01 has 1 902 documentation entries 1 311 patterns 1 336 profiles and 1 352 ProRules See also EditUniprot the universal protein database a central resource on protein information PROSITE adds data to it InterPro a centralized database grouping data from databases of protein families domains and functional sites part of the data come from PROSITE Protein subcellular localization prediction another example of use of PROSITE References Edit De Castro E Sigrist CJA Gattiker A Bulliard V Langendijk Genevaux PS Gasteiger E Bairoch A Hulo N 2006 ScanProsite detection of PROSITE signature matches and ProRule associated functional and structural residues in proteins Nucleic Acids Res 34 Web Server issue W362 365 doi 10 1093 nar gkl124 PMC 1538847 PMID 16845026 Hulo N Bairoch A Bulliard V Cerutti L Cuche B De Castro E Lachaize C Langendijk Genevaux PS Sigrist CJA 2007 The 20 years of PROSITE Nucleic Acids Res 36 Database issue D245 9 doi 10 1093 nar gkm977 PMC 2238851 PMID 18003654 Sigrist CJ De Castro E Langendijk Genevaux PS Le Saux V Bairoch A Hulo N 2005 ProRule a new database containing functional and structural information on PROSITE profiles Bioinformatics 21 21 4060 4066 doi 10 1093 bioinformatics bti614 PMID 16091411 External links EditOfficial website ProRule database of rules based on PROSITE predictors Retrieved from https en wikipedia org w index php title PROSITE amp oldid 1166578679, wikipedia, wiki, book, books, library,
