This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Proarrhythmia" – news · newspapers · books · scholar · JSTOR(May 2019)
Proarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias.
Roden DM (August 1998). "Mechanisms and management of proarrhythmia". Am. J. Cardiol. 82 (4A): 49I–57I. doi:10.1016/S0002-9149(98)00472-X. PMID 9737654.
December 18, 2023
proarrhythmia, this, article, needs, more, reliable, medical, references, verification, relies, heavily, primary, sources, please, review, contents, article, appropriate, references, unsourced, poorly, sourced, material, challenged, removed, find, sources, new. This article needs more reliable medical references for verification or relies too heavily on primary sources Please review the contents of the article and add the appropriate references if you can Unsourced or poorly sourced material may be challenged and removed Find sources Proarrhythmia news newspapers books scholar JSTOR May 2019 Proarrhythmia is a new or more frequent occurrence of pre existing arrhythmias paradoxically precipitated by antiarrhythmic therapy which means it is a side effect associated with the administration of some existing antiarrhythmic drugs as well as drugs for other indications In other words it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias Contents 1 Types of proarrhythmia 1 1 Ventricular proarrhythmia 1 2 Atrial proarrhythmia 1 3 Abnormalities of conduction or impulse formation 2 Increased risk 3 Clinical pointers 3 1 Class IA drugs 3 2 Class IC drugs 3 3 Class III drugs 4 References 5 External linksTypes of proarrhythmia editAccording to the Vaughan Williams classification VW of antiarrhythmic drugs there are 3 main types of Proarrhythmia during treatment with various antiarrhythmic drugs for Atrial Fibrillation or Atrial flutter Ventricular proarrhythmia edit Torsades de pointes VW type IA and type III drugs Sustained monomorphic ventricular tachycardia usually VW type IC drugs Sustained polymorphic ventricular tachycardia ventricular fibrillation without long QT VW types IA IC and III drugs Atrial proarrhythmia edit Conversion of atrial fibrillation to flutter usually VW type IC drugs or amiodarone May be a desired effect Increase of defibrillation threshold a potential problem with VW type IC drugs Provocation of recurrence probably VW types IA IC and III drugs It is rare Abnormalities of conduction or impulse formation edit Sinus node dysfunction atrioventricular block almost all drugs Accelerate conduction over accessory pathway digoxin intravenous verapamil or diltiazem Acceleration of ventricular rate during atrial fibrillation VW type IA and type IC drugs Increased risk editPresence of structural heart disease especially LV systolic dysfunction Class IC agents Increased age Females Clinical pointers editClass IA drugs edit Dose independent occurring at normal levels Follow QT interval keep ms Class IC drugs edit May be provoked by increased heart rate Exercise stress tests after loading Class III drugs edit Dose dependent Follow bradycardia prolonged QT closely References editExternal links editRoden DM August 1998 Mechanisms and management of proarrhythmia Am J Cardiol 82 4A 49I 57I doi 10 1016 S0002 9149 98 00472 X PMID 9737654 Retrieved from https en wikipedia org w index php title Proarrhythmia amp oldid 1005663598, wikipedia, wiki, book, books, library,
