The Pribnow box (also known as the Pribnow-Schaller box) is a sequence of TATAAT of six nucleotides (thymine, adenine, thymine, etc.) that is an essential part of a promoter site on DNA for transcription to occur in bacteria.[1][2] It is an idealized or consensus sequence—that is, it shows the most frequently occurring base at each position in many promoters analyzed; individual promoters often vary from the consensus at one or more positions. It is also commonly called the -10 sequence or element, because it is centered roughly ten base pairs upstream from the site of initiation of transcription.
The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes and archaea: it is recognized and bound by a subunit of RNA polymerase during initiation of transcription.[3] This region of the DNA is also the first place where base pairs separate during prokaryotic transcription to allow access to the template strand. The AT-richness is important to allow this separation, since adenine and thymine are easier to break apart (not only due to fewer hydrogen bonds, but also due to weaker base stacking effects).[4]
The term "Pribnow box" is used in episode 13 of Neon Genesis Evangelion, in reference to the chamber holding simulation Evangelions for testing purposes.
^ ab Pribnow, David (March 1975). "Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter". PNAS. 72 (3): 784–788. Bibcode:1975PNAS...72..784P. doi:10.1073/pnas.72.3.784. ISSN 1091-6490. PMC432404. PMID 1093168.
^ ab Schaller, Heinz; Gray, Christopher; Herrman, Karin (February 1975). "Nucleotide sequence of an RNA polymerase binding site from the DNA of Bacteriophage fd". PNAS. 72 (2): 737–741. Bibcode:1975PNAS...72..737S. doi:10.1073/pnas.72.2.737. ISSN 1091-6490. PMC432391. PMID 1054851.
^Feklistov, Andrey; Darst, Seth (2011). "Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit". Cell. 147 (6): 1257–69. doi:10.1016/j.cell.2011.10.041. PMC3245737. PMID 22136875.
^ Yakovchuk, Peter; Protozanova, Ekaterina; Frank-Kamenetskii, Maxim D. (January 2006). "Base-stacking and base-pairing contributions into thermal stability of the DNA double helix". Nucleic Acids Research. 34 (2): 564–574. doi:10.1093/nar/gkj454. ISSN 0305-1048. PMC1360284. PMID 16449200.
^Harley, Calvin B.; Reynolds, Robert P. (March 1987). "Analysis of E. coli promoter sequences" (PDF, 0.9 MB). Nucleic Acids Research. 15 (5): 2343–2361. doi:10.1093/nar/15.5.2343. ISSN 0305-1048. PMC340638. PMID 3550697.
This genetics article is a stub. You can help Wikipedia by expanding it.
pribnow, also, known, pribnow, schaller, sequence, tataat, nucleotides, thymine, adenine, thymine, that, essential, part, promoter, site, transcription, occur, bacteria, idealized, consensus, sequence, that, shows, most, frequently, occurring, base, each, posi. The Pribnow box also known as the Pribnow Schaller box is a sequence of TATAAT of six nucleotides thymine adenine thymine etc that is an essential part of a promoter site on DNA for transcription to occur in bacteria 1 2 It is an idealized or consensus sequence that is it shows the most frequently occurring base at each position in many promoters analyzed individual promoters often vary from the consensus at one or more positions It is also commonly called the 10 sequence or element because it is centered roughly ten base pairs upstream from the site of initiation of transcription The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes and archaea it is recognized and bound by a subunit of RNA polymerase during initiation of transcription 3 This region of the DNA is also the first place where base pairs separate during prokaryotic transcription to allow access to the template strand The AT richness is important to allow this separation since adenine and thymine are easier to break apart not only due to fewer hydrogen bonds but also due to weaker base stacking effects 4 It is named after David Pribnow and Heinz Schaller citation needed 1 2 Contents 1 Probability of occurrence of each nucleotide in E coli 2 In fiction 3 See also 4 ReferencesProbability of occurrence of each nucleotide in E coli editT A T A A T 82 89 52 59 49 89 From Harley et al 5 In fiction editThe term Pribnow box is used in episode 13 of Neon Genesis Evangelion in reference to the chamber holding simulation Evangelions for testing purposes See also editTATA boxReferences edit a b Pribnow David March 1975 Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter PNAS 72 3 784 788 Bibcode 1975PNAS 72 784P doi 10 1073 pnas 72 3 784 ISSN 1091 6490 PMC 432404 PMID 1093168 a b Schaller Heinz Gray Christopher Herrman Karin February 1975 Nucleotide sequence of an RNA polymerase binding site from the DNA of Bacteriophage fd PNAS 72 2 737 741 Bibcode 1975PNAS 72 737S doi 10 1073 pnas 72 2 737 ISSN 1091 6490 PMC 432391 PMID 1054851 Feklistov Andrey Darst Seth 2011 Structural Basis for Promoter 10 Element Recognition by the Bacterial RNA Polymerase s Subunit Cell 147 6 1257 69 doi 10 1016 j cell 2011 10 041 PMC 3245737 PMID 22136875 Yakovchuk Peter Protozanova Ekaterina Frank Kamenetskii Maxim D January 2006 Base stacking and base pairing contributions into thermal stability of the DNA double helix Nucleic Acids Research 34 2 564 574 doi 10 1093 nar gkj454 ISSN 0305 1048 PMC 1360284 PMID 16449200 Harley Calvin B Reynolds Robert P March 1987 Analysis of E coli promoter sequences PDF 0 9 MB Nucleic Acids Research 15 5 2343 2361 doi 10 1093 nar 15 5 2343 ISSN 0305 1048 PMC 340638 PMID 3550697 nbsp This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Pribnow box amp oldid 1217773587, wikipedia, wiki, book, books, library,
