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Antihypotensive agent

An antihypotensive agent, also known as a vasopressor agent or simply vasopressor, or pressor, is any substance, whether endogenous or a medication, that tends to raise low blood pressure.[1] Some antihypotensive drugs act as vasoconstrictors to increase total peripheral resistance; some drugs (e.g. glucocorticoids) sensitize adrenoreceptors to catecholamines;[2] and others (e.g. dopamine, dobutamine) increase cardiac output.

If low blood pressure is due to blood loss, then preparations increasing volume of blood circulation—plasma-substituting solutions such as colloid and crystalloid solutions (salt solutions)[3]—will raise the blood pressure without any direct vasopressor activity. Packed red blood cells, plasma or whole blood should not be used solely for volume expansion or to increase oncotic pressure of circulating blood.[medical citation needed] Blood products should only be used if reduced oxygen carrying capacity or coagulopathy is present.[medical citation needed] Other causes of either absolute (dehydration, loss of plasma via wound/burns) or relative (third space losses) vascular volume depletion also respond, although blood products are only indicated if significantly anemic.

Classification edit

Antihypotensive agents can be classified as follows:[citation needed]

References edit

  1. ^ . Drugs.com. Archived from the original on 2014-06-06. Retrieved 2014-06-10.
  2. ^ Farias-Silva, Elisângela; Grassi-Kassisse, Dora Maria; Wolf-Nunes, Valéria; Spadari-Bratfisch, Regina Célia (1999). "Stress-induced alteration in the lipolytic response to β-adrenoceptor agonists in rat white adipocytes". Journal of Lipid Research. JLR.org. 40 (9): 1719–1727. doi:10.1016/S0022-2275(20)33419-2. PMID 10484620. Retrieved 2014-06-10.
  3. ^ "Intravenous fluid therapy in adults in hospital". NICE. May 2017. Retrieved October 19, 2018.

antihypotensive, agent, vasopressor, redirects, here, mistakenly, equated, with, vasopressin, which, hyponymous, antihypotensive, agent, also, known, vasopressor, agent, simply, vasopressor, pressor, substance, whether, endogenous, medication, that, tends, rai. Vasopressor redirects here It is not to be mistakenly equated with vasopressin which is hyponymous An antihypotensive agent also known as a vasopressor agent or simply vasopressor or pressor is any substance whether endogenous or a medication that tends to raise low blood pressure 1 Some antihypotensive drugs act as vasoconstrictors to increase total peripheral resistance some drugs e g glucocorticoids sensitize adrenoreceptors to catecholamines 2 and others e g dopamine dobutamine increase cardiac output If low blood pressure is due to blood loss then preparations increasing volume of blood circulation plasma substituting solutions such as colloid and crystalloid solutions salt solutions 3 will raise the blood pressure without any direct vasopressor activity Packed red blood cells plasma or whole blood should not be used solely for volume expansion or to increase oncotic pressure of circulating blood medical citation needed Blood products should only be used if reduced oxygen carrying capacity or coagulopathy is present medical citation needed Other causes of either absolute dehydration loss of plasma via wound burns or relative third space losses vascular volume depletion also respond although blood products are only indicated if significantly anemic Classification editAntihypotensive agents can be classified as follows citation needed Sympathomimetics Epinephrine Noradrenaline Phenylephrine Dobutamine Dopamine Dopexamine Ephedrine Midodrine Amezinium Metaraminol Vasopressin Angiotensinamide S alkylisothiouronium derivatives Difetur Izoturon Glucocorticoids and mineralocorticoids Hydrocortisone Prednisone Prednisolone Dexamethasone Betamethasone Fludrocortisone Positive inotropic agents Cardiac glycosides Strophantin K Convallatoxin Digoxin PDE3 inhibitors Amrinone Enoximone Milrinone LevosimendanReferences edit Antihypotensive definition Drugs com Archived from the original on 2014 06 06 Retrieved 2014 06 10 Farias Silva Elisangela Grassi Kassisse Dora Maria Wolf Nunes Valeria Spadari Bratfisch Regina Celia 1999 Stress induced alteration in the lipolytic response to b adrenoceptor agonists in rat white adipocytes Journal of Lipid Research JLR org 40 9 1719 1727 doi 10 1016 S0022 2275 20 33419 2 PMID 10484620 Retrieved 2014 06 10 Intravenous fluid therapy in adults in hospital NICE May 2017 Retrieved October 19 2018 Retrieved from https en wikipedia org w index php title Antihypotensive agent amp oldid 1175800403, wikipedia, wiki, book, books, library,

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