PSK is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer.[3]
Preliminary studies examining PSK include its use in conjunction with chemotherapy for colorectal cancer,[4][5] non-small cell lung carcinoma,[6] breast cancer,[7] liver cancer,[8] and leukemia.[9]
Chemistryedit
PSK is a protein polysaccharide consisting of a beta-glucan β-1,4 main chain with β-1,3 and β-1,6 side chains. The approximate molecular weight of PSK is 100,000 Da, and the protein component is reported at the β-1,6 side chain.[10] PSK is isolated from the "CM-101" strain of Trametes versicolor. The analogous compound PSP, is derived from the "COV-1" strain of Trametes versicolor.[11]
^Yang, Dandan; Zhou, Zijing; Zhang, Lijuan (2019). Progress in Molecular Biology and Translational Science. Chapter Eight - An overview of fungal glycan-based therapeutics: Academic Press. pp. 135–163. ISBN9780128177402. Retrieved 24 January 2023.
^Habtemariam, Solomon (2020). "Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy". Biomedicines. 8 (5): 135. doi:10.3390/biomedicines8050135. PMC7277906. PMID 32466253.
^M, Fisher; LX, Yang. "Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy". Anticancer Research. Anticancer Res. 22 (3). ISSN 0250-7005. PMID 12168863. Retrieved 2023-12-22.
^Oba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (June 2007). "Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer". Cancer Immunology, Immunotherapy. 56 (6): 905–11. doi:10.1007/s00262-006-0248-1. PMID 17106715. S2CID 161680.
^Mitomi T, Tsuchiya S, Iijima N, et al. (February 1992). "Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa)". Diseases of the Colon and Rectum. 35 (2): 123–30. doi:10.1007/BF02050666. PMID 1735313. S2CID 68080825.
^Hayakawa K, Mitsuhashi N, Saito Y, et al. (1997). "Effect of Krestin as adjuvant treatment following radical radiotherapy in non-small cell lung cancer patients". Cancer Detection and Prevention. 21 (1): 71–7. PMID 9043766.
^Iino Y, Yokoe T, Maemura M, et al. (1995). "Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer". Anticancer Research. 15 (6B): 2907–11. PMID 8669887.
^Suto T, Fukuda S, Moriya N, et al. (1994). "Clinical study of biological response modifiers as maintenance therapy for hepatocellular carcinoma". Cancer Chemotherapy and Pharmacology. 33 Suppl: S145–8. doi:10.1007/BF00686688. PMID 8137477. S2CID 25538345.
^Ohno R, Yamada K, Masaoka T, et al. (1984). "A randomized trial of chemoimmunotherapy of acute nonlymphocytic leukemia in adults using a protein-bound polysaccharide preparation". Cancer Immunology, Immunotherapy. 18 (3): 149–54. doi:10.1007/BF00205503. PMID 6391658. S2CID 24000083.
^Kobayashi H, Matsunaga K, Oguchi Y (1995). "Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview". Cancer Epidemiology, Biomarkers & Prevention. 4 (3): 275–81. PMID 7606203.
^Fisher M, Yang LX (2002). "Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy". Anticancer Research. 22 (3): 1737–54. PMID 12168863.
External linksedit
American Cancer Society's page for .
Memorial Sloan-Kettering Cancer Center's page for Trametes versicolor and Polysaccharide-K.
A by the MD Anderson Cancer Center.
Trametes versicolor and Polysaccharide-K information from Drugs.com.
February 15, 2024
polysaccharide, krestin, protein, bound, polysaccharide, isolated, from, mycelium, trametes, versicolor, trametes, versicolor, mushroom, from, which, isolated, contents, research, chemistry, also, references, external, linksresearch, editpsk, most, commonly, u. Polysaccharide K Krestin PSK is a protein bound polysaccharide isolated from the mycelium 1 2 of Trametes versicolor Trametes versicolor the mushroom from which PSK was isolated Contents 1 Research 2 Chemistry 3 See also 4 References 5 External linksResearch editPSK is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia especially in Japan PSK has a documented anti tumor activity both in vitro and in vitro in various types of cancers including colorectal gastric breast liver pancreatic and lung cancer 3 Preliminary studies examining PSK include its use in conjunction with chemotherapy for colorectal cancer 4 5 non small cell lung carcinoma 6 breast cancer 7 liver cancer 8 and leukemia 9 Chemistry editPSK is a protein polysaccharide consisting of a beta glucan b 1 4 main chain with b 1 3 and b 1 6 side chains The approximate molecular weight of PSK is 100 000 Da and the protein component is reported at the b 1 6 side chain 10 PSK is isolated from the CM 101 strain of Trametes versicolor The analogous compound PSP is derived from the COV 1 strain of Trametes versicolor 11 See also edit nbsp Fungi portalMedicinal mushrooms Polysaccharide peptideReferences edit Yang Dandan Zhou Zijing Zhang Lijuan 2019 Progress in Molecular Biology and Translational Science Chapter Eight An overview of fungal glycan based therapeutics Academic Press pp 135 163 ISBN 9780128177402 Retrieved 24 January 2023 Habtemariam Solomon 2020 Trametes versicolor Synn Coriolus versicolor Polysaccharides in Cancer Therapy Targets and Efficacy Biomedicines 8 5 135 doi 10 3390 biomedicines8050135 PMC 7277906 PMID 32466253 M Fisher LX Yang Anticancer effects and mechanisms of polysaccharide K PSK implications of cancer immunotherapy Anticancer Research Anticancer Res 22 3 ISSN 0250 7005 PMID 12168863 Retrieved 2023 12 22 Oba K Teramukai S Kobayashi M Matsui T Kodera Y Sakamoto J June 2007 Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer Cancer Immunology Immunotherapy 56 6 905 11 doi 10 1007 s00262 006 0248 1 PMID 17106715 S2CID 161680 Mitomi T Tsuchiya S Iijima N et al February 1992 Randomized controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum Kanagawa Diseases of the Colon and Rectum 35 2 123 30 doi 10 1007 BF02050666 PMID 1735313 S2CID 68080825 Hayakawa K Mitsuhashi N Saito Y et al 1997 Effect of Krestin as adjuvant treatment following radical radiotherapy in non small cell lung cancer patients Cancer Detection and Prevention 21 1 71 7 PMID 9043766 Iino Y Yokoe T Maemura M et al 1995 Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer Anticancer Research 15 6B 2907 11 PMID 8669887 Suto T Fukuda S Moriya N et al 1994 Clinical study of biological response modifiers as maintenance therapy for hepatocellular carcinoma Cancer Chemotherapy and Pharmacology 33 Suppl S145 8 doi 10 1007 BF00686688 PMID 8137477 S2CID 25538345 Ohno R Yamada K Masaoka T et al 1984 A randomized trial of chemoimmunotherapy of acute nonlymphocytic leukemia in adults using a protein bound polysaccharide preparation Cancer Immunology Immunotherapy 18 3 149 54 doi 10 1007 BF00205503 PMID 6391658 S2CID 24000083 Kobayashi H Matsunaga K Oguchi Y 1995 Antimetastatic effects of PSK Krestin a protein bound polysaccharide obtained from basidiomycetes an overview Cancer Epidemiology Biomarkers amp Prevention 4 3 275 81 PMID 7606203 Fisher M Yang LX 2002 Anticancer effects and mechanisms of polysaccharide K PSK implications of cancer immunotherapy Anticancer Research 22 3 1737 54 PMID 12168863 External links editAmerican Cancer Society s page for Trametes versicolor and Polysaccharide K Memorial Sloan Kettering Cancer Center s page for Trametes versicolor and Polysaccharide K A Detailed Scientific Review of Trametes versicolor and Polysaccharide K by the MD Anderson Cancer Center Trametes versicolor and Polysaccharide K information from Drugs com Retrieved from https en wikipedia org w index php title Polysaccharide K amp oldid 1194126791, wikipedia, wiki, book, books, library,
