This article is about polymer containing propyl linker between guanidine groups. For PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide, see Polyhexanide.
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[citation needed]
Disinfectantedit
PAPB solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[citation needed] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).
Contact lens solutionedit
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[citation needed]
polyaminopropyl, biguanide, this, article, about, polymer, containing, propyl, linker, between, guanidine, groups, phmb, antimicrobial, polymer, incorectly, named, polyhexanide, papb, disinfectant, preservative, used, disinfection, skin, cleaning, solutions, c. This article is about polymer containing propyl linker between guanidine groups For PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide see Polyhexanide Polyaminopropyl biguanide PAPB is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses citation needed It is also an ingredient in many deodorant bodysprays citation needed It is a polymer or oligomer where biguanide functional groups are connected by propyl hydrocarbon chains PAPB is specifically bactericidal at very low concentrations 10 mg L and is also fungicidal citation needed Polyaminopropyl biguanide Names Other names Polyamine propyl biguanidine Identifiers CAS Number 133029 32 0 Y Abbreviations PAPB ChemSpider none ECHA InfoCard 100 118 649 UNII DT9D8Z79ET Y Properties Chemical formula C5H11N5 n Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references Contents 1 Biocidal activity 2 Disinfectant 3 Contact lens solution 4 See alsoBiocidal activity editIt has a unique method of action the polymer strands are incorporated into the bacterial cell membrane which disrupts the membrane and reduces its permeability which has a lethal effect to bacteria It is also known to bind to bacterial DNA alter its transcription and cause lethal DNA damage citation needed Disinfectant editPAPB solutions are sold for use as a general disinfectant solution to be applied onto skin As it is not cytotoxic it can be applied directly into wounds citation needed It is also not irritating like more traditional disinfectants such as alcohols ethanol isopropanol and oxidizers iodine Contact lens solution editA contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented citation needed See also editAntimicrobial resistance Polyhexanide a related biguanide disinfectant Benzalkonium chloride Stearalkonium chloride Ethylenediaminetetraacetic acid Triclosan Thiomersal Retrieved from https en wikipedia org w index php title Polyaminopropyl biguanide amp oldid 1222680609, wikipedia, wiki, book, books, library,
