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Pleasantine Mill

April 12, 2024

Pleasantine Mill is a cell biologist and group leader at the MRC Human Genetics Unit at the University of Edinburgh.[1][3] She won the 2018 British Society for Cell Biology Women in Cell Biology Early Career Medal.[4]

Pleasantine Mill
Mill in 2016
Alma materMcGill University (BSc)
University of Toronto (PhD)
Occupation(s)Developmental and cell biologist
Scientific career
FieldsCilia
Genetics
Disease mechanisms
Cell biology
Imaging[1]
InstitutionsUniversity of Edinburgh
The Hospital for Sick Children
ThesisThe role of Shh-dependent Gli activator and repressor functions in epidermal development and disease (2004)
Doctoral advisorChi-chung Hui[2]
Websitewww.ed.ac.uk/profile/pleasantine-mill

Early life and education edit

Mill completed her bachelor's degree at McGill University in 1999.[5] She joined University of Toronto for her PhD, working on transcription factors in the Hedgehog signaling pathway in skin development and tumorigenesis supervised by Chi-chung Hui.[2][5][6][7] Her work contributed to the book Hedgehog-Gli Signaling in Human Disease.[8] She worked at the Hospital for Sick Children and earned her PhD in 2004.[4]

Career and research edit

Mill was awarded a Canadian Natural Sciences and Engineering Research Council (NSERC) postdoctoral research fellowship to join the Medical Research Council (MRC) Human Genetics Unit (HGU). She worked on mouse mutagenesis.[5] During her postdoctoral work she identified several novel mutant lines that disrupted developmental signalling.[4] Mill was appointed a Caledonian Research Foundation Fellow at the University of Edinburgh.[5] Since 2014 Mill has established a cilia-focussed programme that uses Small interfering RNA screening.[5] She works with clinical geneticists to understand the molecular phenotypes that underlie ciliopathies in humans.[4] She was awarded a £1.5 million grant from UK Research and Innovation (UKRI) to explore mammalian cilia in development and disease.[9]

Mill examined the influence of the Retinitis pigmentosa GTPase regulator (RPGR) gene on the cells in the eye and how they can cause X-linked retinitis pigmentosa, a condition which causes blindness in middle age.[10] Photoreceptors decay in retinitis pigmentosa patients due to a flaw in the RPGR gene.[10] In 2018 Mill identified a new therapeutic technique for primary ciliary dyskinesia (PCD).[11] She proposed that drugs which make dynein motor proteins functional could improve the quality of life of patients with primary ciliary dyskinesia.[11][12] In October 2018 Mill chaired the first PCD awareness day.[13] She proposed that the Government of the United Kingdom introduced early genetic diagnosis of PCD for babies with no identified causes of neonatal respiratory distress.[14] She hopes that genome editing will be able to treat PCD.[14] She collaborated with Richard Mort at Lancaster University to develop a fluorescent biosensor that illuminates dividing cilia and cells.[15] The technique allows the study of the interactions between cilia and cells in development, regeneration and disease.[16] It investigates how cilia length and dynamics impact the speed of cell division and tissue development.[17]

Awards and honours edit

In 2018 Mill was awarded the British Society for Cell Biology Women in Cell Biology Early Career Medal.[4]

References edit

  1. ^ a b Pleasantine Mill publications indexed by Google Scholar  
  2. ^ a b Mill, Pleasantine (2004). The role of Shh-dependent Gli activator and repressor functions in epidermal development and disease (PhD thesis). University of Toronto. OCLC 61300528. ProQuest 305068261. (subscription required)
  3. ^ Pleasantine Mill publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ a b c d e "WICB Medal Winner 2019: Pleasantine Mill". British Society for Cell Biology. Retrieved 2018-12-17.
  5. ^ a b c d e "Dr Pleasantine Mill". ed.ac.uk. University of Edinburgh. Retrieved 2018-12-17.
  6. ^ Nicolas, Michael; Wolfer, Anita; Raj, Kenneth; Kummer, J. Alain; Mill, Pleasantine; van Noort, Mascha; Hui, Chi-chung; Clevers, Hans; Dotto, G. Paolo; Radtke, Freddy (2003). "Notch1 functions as a tumor suppressor in mouse skin". Nature Genetics. 33 (3): 416–421. doi:10.1038/ng1099. ISSN 1061-4036. PMID 12590261. S2CID 12359172.  
  7. ^ Fernandes, Karl J. L.; McKenzie, Ian A.; Mill, Pleasantine; Smith, Kristen M.; Akhavan, Mahnaz; Barnabé-Heider, Fanie; Biernaskie, Jeff; Junek, Adrienne; Kobayashi, Nao R.; Toma, Jean G.; Kaplan, David R.; Labosky, Patricia A.; Rafuse, Victor; Hui, Chi-Chung; Miller, Freda D. (2004). "A dermal niche for multipotent adult skin-derived precursor cells". Nature Cell Biology. 6 (11): 1082–1093. doi:10.1038/ncb1181. ISSN 1465-7392. PMID 15517002. S2CID 34420816.  
  8. ^ Ruiz i Altaba, Ariel (2006). Hedgehog-Gli Signaling in Human Disease. doi:10.1007/0-387-33777-6. ISBN 9781489989765.
  9. ^ "Molecular Genetics of Mammalian Cilia in Development and Disease". ukri.org. Retrieved 2018-12-17.
  10. ^ a b "Blindness study shows how gene causes middle-age sight loss". ScienceDaily.com. Retrieved 2018-12-17.
  11. ^ a b "Molecular motor clue to rare genetic disorder". The University of Edinburgh. Retrieved 2018-12-17.
  12. ^ Mali, Girish R.; Yeyati, Patricia L.; Mizuno, Seiya; Dodd, Daniel O.; Tennant, Peter A.; Keighren, Margaret A.; Lage, Petra zur; Shoemark, Amelia; Garcia-Munoz, Amaya (2018). "ZMYND10 functions in a chaperone relay during axonemal dynein assembly". eLife. 7. doi:10.7554/elife.34389. PMC 6044906. PMID 29916806.
  13. ^ "Scottish PCD Awareness Day – PCD Support". pcdsupport.org.uk. Retrieved 2018-12-17.
  14. ^ a b "Written evidence - Pleasantine Mill and Jane Lucas, MRC Human Genetics Unit". data.parliament.uk. Retrieved 2018-12-17.
  15. ^ "Monitoring real time changes during cell division". phys.org. Retrieved 2018-12-17.
  16. ^ Mill, Pleasantine; Lockhart, Paul J.; Fitzpatrick, Elizabeth; Mountford, Hayley S.; Hall, Emma A.; Reijns, Martin A.M.; Keighren, Margaret; Bahlo, Melanie; Bromhead, Catherine J.; Budd, Peter; Aftimos, Salim; Delatycki, Martin B.; Savarirayan, Ravi; Jackson, Ian J.; Amor, David J. (2011). "Human and Mouse Mutations in WDR35 Cause Short-Rib Polydactyly Syndromes Due to Abnormal Ciliogenesis". American Journal of Human Genetics. 88 (4): 508–515. doi:10.1016/j.ajhg.2011.03.015. ISSN 0002-9297. PMC 3071922. PMID 21473986.
  17. ^ "Seeing is believing: monitoring real time changes during cell division". lancaster.ac.uk. Retrieved 2018-12-17.

April 12, 2024
pleasantine, mill, cell, biologist, group, leader, human, genetics, unit, university, edinburgh, 2018, british, society, cell, biology, women, cell, biology, early, career, medal, mill, 2016alma, matermcgill, university, university, toronto, occupation, develo. Pleasantine Mill is a cell biologist and group leader at the MRC Human Genetics Unit at the University of Edinburgh 1 3 She won the 2018 British Society for Cell Biology Women in Cell Biology Early Career Medal 4 Pleasantine MillMill in 2016Alma materMcGill University BSc University of Toronto PhD Occupation s Developmental and cell biologistScientific careerFieldsCiliaGeneticsDisease mechanismsCell biologyImaging 1 InstitutionsUniversity of EdinburghThe Hospital for Sick ChildrenThesisThe role of Shh dependent Gli activator and repressor functions in epidermal development and disease 2004 Doctoral advisorChi chung Hui 2 Websitewww wbr ed wbr ac wbr uk wbr profile wbr pleasantine mill Contents 1 Early life and education 2 Career and research 2 1 Awards and honours 3 ReferencesEarly life and education editMill completed her bachelor s degree at McGill University in 1999 5 She joined University of Toronto for her PhD working on transcription factors in the Hedgehog signaling pathway in skin development and tumorigenesis supervised by Chi chung Hui 2 5 6 7 Her work contributed to the book Hedgehog Gli Signaling in Human Disease 8 She worked at the Hospital for Sick Children and earned her PhD in 2004 4 Career and research editMill was awarded a Canadian Natural Sciences and Engineering Research Council NSERC postdoctoral research fellowship to join the Medical Research Council MRC Human Genetics Unit HGU She worked on mouse mutagenesis 5 During her postdoctoral work she identified several novel mutant lines that disrupted developmental signalling 4 Mill was appointed a Caledonian Research Foundation Fellow at the University of Edinburgh 5 Since 2014 Mill has established a cilia focussed programme that uses Small interfering RNA screening 5 She works with clinical geneticists to understand the molecular phenotypes that underlie ciliopathies in humans 4 She was awarded a 1 5 million grant from UK Research and Innovation UKRI to explore mammalian cilia in development and disease 9 Mill examined the influence of the Retinitis pigmentosa GTPase regulator RPGR gene on the cells in the eye and how they can cause X linked retinitis pigmentosa a condition which causes blindness in middle age 10 Photoreceptors decay in retinitis pigmentosa patients due to a flaw in the RPGR gene 10 In 2018 Mill identified a new therapeutic technique for primary ciliary dyskinesia PCD 11 She proposed that drugs which make dynein motor proteins functional could improve the quality of life of patients with primary ciliary dyskinesia 11 12 In October 2018 Mill chaired the first PCD awareness day 13 She proposed that the Government of the United Kingdom introduced early genetic diagnosis of PCD for babies with no identified causes of neonatal respiratory distress 14 She hopes that genome editing will be able to treat PCD 14 She collaborated with Richard Mort at Lancaster University to develop a fluorescent biosensor that illuminates dividing cilia and cells 15 The technique allows the study of the interactions between cilia and cells in development regeneration and disease 16 It investigates how cilia length and dynamics impact the speed of cell division and tissue development 17 Awards and honours edit In 2018 Mill was awarded the British Society for Cell Biology Women in Cell Biology Early Career Medal 4 References edit a b Pleasantine Mill publications indexed by Google Scholar nbsp a b Mill Pleasantine 2004 The role of Shh dependent Gli activator and repressor functions in epidermal development and disease PhD thesis University of Toronto OCLC 61300528 ProQuest 305068261 subscription required Pleasantine Mill publications indexed by the Scopus bibliographic database subscription required a b c d e WICB Medal Winner 2019 Pleasantine Mill British Society for Cell Biology Retrieved 2018 12 17 a b c d e Dr Pleasantine Mill ed ac uk University of Edinburgh Retrieved 2018 12 17 Nicolas Michael Wolfer Anita Raj Kenneth Kummer J Alain Mill Pleasantine van Noort Mascha Hui Chi chung Clevers Hans Dotto G Paolo Radtke Freddy 2003 Notch1 functions as a tumor suppressor in mouse skin Nature Genetics 33 3 416 421 doi 10 1038 ng1099 ISSN 1061 4036 PMID 12590261 S2CID 12359172 nbsp Fernandes Karl J L McKenzie Ian A Mill Pleasantine Smith Kristen M Akhavan Mahnaz Barnabe Heider Fanie Biernaskie Jeff Junek Adrienne Kobayashi Nao R Toma Jean G Kaplan David R Labosky Patricia A Rafuse Victor Hui Chi Chung Miller Freda D 2004 A dermal niche for multipotent adult skin derived precursor cells Nature Cell Biology 6 11 1082 1093 doi 10 1038 ncb1181 ISSN 1465 7392 PMID 15517002 S2CID 34420816 nbsp Ruiz i Altaba Ariel 2006 Hedgehog Gli Signaling in Human Disease doi 10 1007 0 387 33777 6 ISBN 9781489989765 Molecular Genetics of Mammalian Cilia in Development and Disease ukri org Retrieved 2018 12 17 a b Blindness study shows how gene causes middle age sight loss ScienceDaily com Retrieved 2018 12 17 a b Molecular motor clue to rare genetic disorder The University of Edinburgh Retrieved 2018 12 17 Mali Girish R Yeyati Patricia L Mizuno Seiya Dodd Daniel O Tennant Peter A Keighren Margaret A Lage Petra zur Shoemark Amelia Garcia Munoz Amaya 2018 ZMYND10 functions in a chaperone relay during axonemal dynein assembly eLife 7 doi 10 7554 elife 34389 PMC 6044906 PMID 29916806 Scottish PCD Awareness Day PCD Support pcdsupport org uk Retrieved 2018 12 17 a b Written evidence Pleasantine Mill and Jane Lucas MRC Human Genetics Unit data parliament uk Retrieved 2018 12 17 Monitoring real time changes during cell division phys org Retrieved 2018 12 17 Mill Pleasantine Lockhart Paul J Fitzpatrick Elizabeth Mountford Hayley S Hall Emma A Reijns Martin A M Keighren Margaret Bahlo Melanie Bromhead Catherine J Budd Peter Aftimos Salim Delatycki Martin B Savarirayan Ravi Jackson Ian J Amor David J 2011 Human and Mouse Mutations in WDR35 Cause Short Rib Polydactyly Syndromes Due to Abnormal Ciliogenesis American Journal of Human Genetics 88 4 508 515 doi 10 1016 j ajhg 2011 03 015 ISSN 0002 9297 PMC 3071922 PMID 21473986 Seeing is believing monitoring real time changes during cell division lancaster ac uk Retrieved 2018 12 17 Retrieved from https en wikipedia org w index php title Pleasantine Mill amp oldid 1170383239, wikipedia, wiki, book, books, library,

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