Physiological agonism describes the action of a substance which ultimately produces the same effects in the body as another substance—as if they were both agonists at the same receptor—without actually binding to the same receptor. Physiological antagonism describes the behavior of a substance that produces effects counteracting those of another substance (a result similar to that produced by an antagonist blocking the action of an agonist at the same receptor) using a mechanism that does not involve binding to the same receptor.
There are several substances that have antihistaminergic action despite not being ligands for the histamine receptor. For instance, epinephrine raises arterial pressure through vasoconstriction mediated by A1-adrenergic receptor activation, in contrast to histamine, which lowers arterial pressure. Thus, despite not being true antihistamines because they do not bind to and block the histamine receptor, epinephrine and other such substances are physiological antagonists to histamine.
Referencesedit
^Pietrapiana, D; Sala, M; Prat, M; Sinigaglia, F (Aug 15, 2005). "Met identification on human platelets: role of hepatocyte growth factor in the modulation of platelet activation". FEBS Letters. 579 (20): 4550–4. doi:10.1016/j.febslet.2005.06.072. PMID 16083876. S2CID 39722975.
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physiological, agonism, antagonism, physiological, agonism, describes, action, substance, which, ultimately, produces, same, effects, body, another, substance, they, were, both, agonists, same, receptor, without, actually, binding, same, receptor, physiologica. Physiological agonism describes the action of a substance which ultimately produces the same effects in the body as another substance as if they were both agonists at the same receptor without actually binding to the same receptor Physiological antagonism describes the behavior of a substance that produces effects counteracting those of another substance a result similar to that produced by an antagonist blocking the action of an agonist at the same receptor using a mechanism that does not involve binding to the same receptor Contents 1 Examples 1 1 Physiological agonists 1 2 Physiological antagonists 2 ReferencesExamples editPhysiological agonists edit Epinephrine induces platelet aggregation and so does hepatocyte growth factor HGF 1 Thus they are physiological agonists to each other Physiological antagonists edit There are several substances that have antihistaminergic action despite not being ligands for the histamine receptor For instance epinephrine raises arterial pressure through vasoconstriction mediated by A1 adrenergic receptor activation in contrast to histamine which lowers arterial pressure Thus despite not being true antihistamines because they do not bind to and block the histamine receptor epinephrine and other such substances are physiological antagonists to histamine References edit Pietrapiana D Sala M Prat M Sinigaglia F Aug 15 2005 Met identification on human platelets role of hepatocyte growth factor in the modulation of platelet activation FEBS Letters 579 20 4550 4 doi 10 1016 j febslet 2005 06 072 PMID 16083876 S2CID 39722975 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Physiological agonism and antagonism amp oldid 984705464, wikipedia, wiki, book, books, library,
