Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).[1]
^Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". EMBO J. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC2752028. PMID 19779456.
phosphatidylinositol, kinase, related, kinase, pikks, family, protein, kinases, with, sequence, similarity, phosphatidylinositol, kinases, pi3ks, contents, members, structure, references, external, linksmembers, editthe, human, pikk, family, includes, members,. Phosphatidylinositol 3 kinase related kinases PIKKs are a family of Ser Thr protein kinases with sequence similarity to phosphatidylinositol 3 kinases PI3Ks 1 Contents 1 Members 2 Structure 3 References 4 External linksMembers EditThe human PIKK family includes six members Gene Protein FunctionATM ataxia telangiectasia mutated response to DNA damageATR ataxia and Rad3 related PRKDC DNA dependent protein kinase catalytic subunit DNA PKcs MTOR mammalian target of rapamycin mTOR nutrient regulated kinase that controls metabolism and cell growthSMG1 suppressor of morphogenesis in genitalia regulates nonsense mediated mRNA decayTRRAP transformation transcription domain associated protein transcription factor co activatorStructure EditPIKKs proteins contain the following four domains N terminus FRAP ATM TRRAP FAT domain Pfam PF02259 kinase domain KD PI3 PI4 kinase PIKK regulatory domain PRD and C terminus FAT C terminal FATC domain Pfam PF02260References Edit Lempiainen H Halazonetis TD October 2009 Emerging common themes in regulation of PIKKs and PI3Ks EMBO J 28 20 3067 73 doi 10 1038 emboj 2009 281 PMC 2752028 PMID 19779456 External links EditKinase Family PIKK at WikiKinome Portal Biology This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Phosphatidylinositol 3 kinase related kinase amp oldid 1117740159, wikipedia, wiki, book, books, library,
