Phenylpyruvate tautomerase has also been found to exhibit the same keto-enol tautomerism for 4-Hydroxyphenylpyruvic acid, which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring.[1]
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.
Structural studiesedit
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.
Referencesedit
^Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Björk P, Jacobsson L, Rorsman H (1997). "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase". FEBS Lett. 417 (1): 85–8. doi:10.1016/s0014-5793(97)01261-1. PMID 9395080. S2CID 27800700.
Blasi F, Fragomele F, Covelli I (1969). "Thyroidal phenylpyruvate tautomerase. Isolation and characterization". J. Biol. Chem. 244 (18): 4864–70. PMID 5824560.
phenylpyruvate, tautomerase, enzymology, phenylpyruvate, tautomerase, macrophage, migration, inhibitory, factor, enzyme, that, catalyzes, chemical, reactionphenylpyruvate, tautomeraseidentifiersec, 1cas, 9023, 5databasesintenzintenz, viewbrendabrenda, entryexp. In enzymology phenylpyruvate tautomerase or Macrophage migration inhibitory factor EC 5 3 2 1 is an enzyme that catalyzes the chemical reactionphenylpyruvate tautomeraseIdentifiersEC no 5 3 2 1CAS no 9023 54 5DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins keto phenylpyruvate displaystyle rightleftharpoons enol phenylpyruvate Phenylpyruvate tautomerase has also been found to exhibit the same keto enol tautomerism for 4 Hydroxyphenylpyruvic acid which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring 1 This enzyme belongs to the family of isomerases specifically those intramolecular oxidoreductases interconverting keto and enol groups The systematic name of this enzyme class is phenylpyruvate keto enol isomerase This enzyme is also called phenylpyruvic keto enol isomerase This enzyme participates in tyrosine metabolism and phenylalanine metabolism Structural studies editAs of late 2007 7 structures have been solved for this class of enzymes with PDB accession codes 1GYJ 1GYX 1GYY 2GDG 2OOH 2OOW and 2OOZ References edit Rosengren E Aman P Thelin S Hansson C Ahlfors S Bjork P Jacobsson L Rorsman H 1997 The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase FEBS Lett 417 1 85 8 doi 10 1016 s0014 5793 97 01261 1 PMID 9395080 S2CID 27800700 Blasi F Fragomele F Covelli I 1969 Thyroidal phenylpyruvate tautomerase Isolation and characterization J Biol Chem 244 18 4864 70 PMID 5824560 Knox WE 1955 p Hydroxyphenylpyruvate enol keto tautomerase Methods Enzymol 2 289 295 doi 10 1016 s0076 6879 55 02202 7 KNOX WE PITT BM 1957 Enzymic catalysis of the keto enol tautomerization of phenylpyruvic acids J Biol Chem 225 2 675 88 PMID 13416270 Portal nbsp Biology This isomerase article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Phenylpyruvate tautomerase amp oldid 1187352282, wikipedia, wiki, book, books, library,
