Phenylpyrazole insecticides are a class of chemically-related broad-spectrum insecticides. The chemical structures of these insecticides are characterized by a central pyrazole ring with a phenyl group attached to one of the nitrogen atoms of the pyrazole.
Chemical structure of fipronil, a common phenylpyrazole insecticide
Phenylpyrazole insecticides were developed in response to increasing pesticide resistance to other chemicals. Now, along with neonicotinoids, they are some of the most widely-used pesticides.[1]
Mode of Actionedit
Phenylpyrazole insecticides function by blocking glutamate-activated chloride channels in insects. Mammals do not have this type of chloride channel, making them much less susceptible to its effects. However, they do have the capacity to disrupt epithelial cells in the human intestine and adversely impact human health.[1]
^ abVidau, C.; Brunet, J. L.; Badiou, A.; Belzunces, L. P. (2009). "Phenylpyrazole insecticides induce cytotoxicity by altering mechanisms involved in cellular energy supply in the human epithelial cell model Caco-2". Toxicology in Vitro. 23 (4): 589–597. doi:10.1016/j.tiv.2009.01.017.
External linksedit
Media related to phenylpyrazole insecticides at Wikimedia Commons
January 01, 1970
phenylpyrazole, insecticides, class, chemically, related, broad, spectrum, insecticides, chemical, structures, these, insecticides, characterized, central, pyrazole, ring, with, phenyl, group, attached, nitrogen, atoms, pyrazole, chemical, structure, fipronil,. Phenylpyrazole insecticides are a class of chemically related broad spectrum insecticides The chemical structures of these insecticides are characterized by a central pyrazole ring with a phenyl group attached to one of the nitrogen atoms of the pyrazole Chemical structure of fipronil a common phenylpyrazole insecticide Contents 1 History 2 Mode of Action 3 Examples 4 References 5 External linksHistory editPhenylpyrazole insecticides were developed in response to increasing pesticide resistance to other chemicals Now along with neonicotinoids they are some of the most widely used pesticides 1 Mode of Action editPhenylpyrazole insecticides function by blocking glutamate activated chloride channels in insects Mammals do not have this type of chloride channel making them much less susceptible to its effects However they do have the capacity to disrupt epithelial cells in the human intestine and adversely impact human health 1 Examples editExamples include acetoprole ethiprole fipronil flufiprole pyraclofos pyrafluprole pyriprole pyrolan vaniliproleReferences edit a b Vidau C Brunet J L Badiou A Belzunces L P 2009 Phenylpyrazole insecticides induce cytotoxicity by altering mechanisms involved in cellular energy supply in the human epithelial cell model Caco 2 Toxicology in Vitro 23 4 589 597 doi 10 1016 j tiv 2009 01 017 External links edit nbsp Media related to phenylpyrazole insecticides at Wikimedia Commons Retrieved from https en wikipedia org w index php title Phenylpyrazole insecticides amp oldid 1096291038, wikipedia, wiki, book, books, library,
