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Peptaibol

February 24, 2023

Peptaibols are biologically active peptides containing between seven and twenty amino acid residues, some of which are non-proteinogenic amino acids. In particular, they contain α-aminoisobutyric acid along with other unusual aminoacids such as ethylnorvaline, isovaline and hydroxyproline; the N-terminus is acetylated, and the C-terminal amino acid is hydroxylated to an acid alcohol. They are named pebtaibols due to them being peptides containing α-aminoisobutyric acid (Aib) and ending in an alcohol.[1] They are produced by certain fungi, mainly in the genus Trichoderma, as secondary metabolites which function as antibiotics and antifungal agents.[1][2] Some are referred to as trichorzianines.[3] They are amphipathic which allows them to form voltage-dependent ion channels in cell membranes which create holes in the membrane making them leaky and leading to the death of the cells. As of 2001, over 317 peptaibols had been identified.[1] The most widely known peptaibol is alamethicin.

Identifiers
SymbolN/A
TCDB1.D.5
OPM superfamily44
OPM protein1ob7

References

  1. ^ a b c Chugh JK, Wallace BA (August 2001). "Peptaibols: models for ion channels". Biochemical Society Transactions. 29 (Pt 4): 565–70. doi:10.1042/bst0290565. PMID 11498029.
  2. ^ Stoppacher N, Reithner B, Omann M, Zeilinger S, Krska R, Schuhmacher R (2007). "Profiling of trichorzianines in culture samples of Trichoderma atroviride by liquid chromatography/tandem mass spectrometry". Rapid Communications in Mass Spectrometry. 21 (24): 3963–70. Bibcode:2007RCMS...21.3963S. doi:10.1002/rcm.3301. PMID 18008385.
  3. ^ Schirmbock M, Lorito M, Wang Y, Hayes CK, Arisan-Atac I, Scala F, Harman GE, Kubicek CP (December 1994). "Parallel Formation and Synergism of Hydrolytic Enzymes and Peptaibol Antibiotics, Molecular Mechanisms Involved in the Antagonistic Action of Trichoderma harzianum against Phytopathogenic Fungi". Applied and Environmental Microbiology. 60 (12): 4364–70. Bibcode:1994ApEnM..60.4364S. doi:10.1128/AEM.60.12.4364-4370.1994. PMC 201994. PMID 7811076.

External links

  • Petaibol database

February 24, 2023
peptaibol, biologically, active, peptides, containing, between, seven, twenty, amino, acid, residues, some, which, proteinogenic, amino, acids, particular, they, contain, aminoisobutyric, acid, along, with, other, unusual, aminoacids, such, ethylnorvaline, iso. Peptaibols are biologically active peptides containing between seven and twenty amino acid residues some of which are non proteinogenic amino acids In particular they contain a aminoisobutyric acid along with other unusual aminoacids such as ethylnorvaline isovaline and hydroxyproline the N terminus is acetylated and the C terminal amino acid is hydroxylated to an acid alcohol They are named pebtaibols due to them being peptides containing a aminoisobutyric acid Aib and ending in an alcohol 1 They are produced by certain fungi mainly in the genus Trichoderma as secondary metabolites which function as antibiotics and antifungal agents 1 2 Some are referred to as trichorzianines 3 They are amphipathic which allows them to form voltage dependent ion channels in cell membranes which create holes in the membrane making them leaky and leading to the death of the cells As of 2001 over 317 peptaibols had been identified 1 The most widely known peptaibol is alamethicin IdentifiersSymbolN ATCDB1 D 5OPM superfamily44OPM protein1ob7References Edit a b c Chugh JK Wallace BA August 2001 Peptaibols models for ion channels Biochemical Society Transactions 29 Pt 4 565 70 doi 10 1042 bst0290565 PMID 11498029 Stoppacher N Reithner B Omann M Zeilinger S Krska R Schuhmacher R 2007 Profiling of trichorzianines in culture samples of Trichoderma atroviride by liquid chromatography tandem mass spectrometry Rapid Communications in Mass Spectrometry 21 24 3963 70 Bibcode 2007RCMS 21 3963S doi 10 1002 rcm 3301 PMID 18008385 Schirmbock M Lorito M Wang Y Hayes CK Arisan Atac I Scala F Harman GE Kubicek CP December 1994 Parallel Formation and Synergism of Hydrolytic Enzymes and Peptaibol Antibiotics Molecular Mechanisms Involved in the Antagonistic Action of Trichoderma harzianum against Phytopathogenic Fungi Applied and Environmental Microbiology 60 12 4364 70 Bibcode 1994ApEnM 60 4364S doi 10 1128 AEM 60 12 4364 4370 1994 PMC 201994 PMID 7811076 External links EditPetaibol database Retrieved from https en wikipedia org w index php title Peptaibol amp oldid 1132984751, wikipedia, wiki, book, books, library,

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