Pancolitis, in its most general sense, refers to inflammation of the entire colon. This can be caused by a variety of things. Pancolitis or universal colitis is frequently used in a more specific fashion to denote a very severe form of ulcerative colitis. This form of ulcerative colitis is spread throughout the entire large intestine including the right colon, the left colon, the transverse colon, descending colon, and the rectum. A diagnosis can be made using a number of techniques but the most accurate method is direct visualization via a colonoscopy.[1] Symptoms are similar to those of ulcerative colitis but more severe and affect the entire large intestine. Patients with ulcerative colitis generally exhibit symptoms including rectal bleeding as a result of ulcers, pain in the abdominal region, inflammation in varying degrees, and diarrhea (often containing blood). Pancolitis patients exhibit these symptoms and may also experience fatigue, fever, and night sweats.[2][3] Due to the loss of function in the large intestine patients may lose large amounts of weight from being unable to procure nutrients from food.[4] In other cases the blood loss from ulcers can result in anemia which can be treated with iron supplements. Additionally, due to the chronic nature of most cases of pancolitis, patients have a higher chance of developing colon cancer.[citation needed]
Pancolitis
This condition affects the large intestine.
Pancolitis is a kind of inflammatory bowel disease (IBD) that affects the entire internal lining of the colon. The precise causes of this inflammatory disorder are unclear, although physicians currently believe that autoimmune diseases and genetic predispositions might play a role in its progress. Genes that are known to put individuals at risk for Crohn’s disease have been shown to also increase risk of other IBD including pancolitis.[5] Furthermore, an individual may also develop pancolitis if ulcerative colitis of only a small portion of the colon is left untreated or worsens.[3] Current treatment of pancolitis is focused on forcing the disease into remission, a state where the majority of the symptoms subside. Ultimately, the goal is to reach an improved quality of life, reduction in need for medicine, and minimization of the risk of cancer.[3][6] Medication utilized in treatment includes anti-inflammatory agents and corticosteroids to alleviate inflammation and immunomodulators which act to suppress the immune system. Immunomodulators are used in severe cases of ulcerative colitis and often utilized to treat patients with pancolitis who have shown little improvement with anti-inflammatories and corticosteroids.[2][3][5] However, in this case it can further expose the patient to other diseases due to the compromised immune system. A final option of treatment is available in the form of surgery. Generally, this option is reserved for only the cases in which cancer development is highly suspected or major hemorrhaging from ulcers occurs. In this case the entire colon and rectum are removed which both cures the pancolitis and prevents any chance of colon cancer. Patients who undergo surgery either must have their stool collect in a reservoir made in place of the rectum or have the end of the small intestine attached to the anus. In the latter case the diseased portion of the anus must be removed, but the muscles are left intact, allowing bowel movement to still take place.[7]
Referencesedit
^Bennett, A. L.; Buckton, S.; Lawrance, I.; Leong, R. W.; Moore, G.; Andrews, J. M. (2015-12-01). "Ulcerative colitis outpatient management: development and evaluation of tools to support primary care practitioners". Internal Medicine Journal. 45 (12): 1254–1266. doi:10.1111/imj.12872. ISSN 1445-5994. PMID 26256445. S2CID 21182584.
^ abHoy, Sheridan M. (2015-04-29). "Budesonide MMX®: A Review of Its Use in Patients with Mild to Moderate Ulcerative Colitis". Drugs. 75 (8): 879–886. doi:10.1007/s40265-015-0396-8. ISSN 0012-6667. PMID 25920500. S2CID 20149154.
^ abFranke, Andre; Balschun, Tobias; Sina, Christian; Ellinghaus, David; Häsler, Robert; Mayr, Gabriele; Albrecht, Mario; Wittig, Michael; Buchert, Eva (2010). "Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)". Nature Genetics. 42 (4): 292–294. doi:10.1038/ng.553. PMID 20228798. S2CID 205356523.
^Rubin, D. T.; Ananthakrishnan, A. N.; Siegel, C. A.; Sauer, B. G.; Long, M. D. (2019). "Ulcerative Colitis in Adults | American College of Gastroenterology". The American Journal of Gastroenterology. 114 (3): 384–413. doi:10.14309/ajg.0000000000000152. PMID 30840605. S2CID 73473272. Retrieved 2016-06-27.
^Vella, M., Masood, M. R., & Hendry, W. S. (2007). Surgery for ulcerative colitis. Surgeon (Edinburgh University Press), 5(6), 356-362.
External linksedit
Medscape UC
Patient UK UC
January 05, 2024
pancolitis, most, general, sense, refers, inflammation, entire, colon, this, caused, variety, things, universal, colitis, frequently, used, more, specific, fashion, denote, very, severe, form, ulcerative, colitis, this, form, ulcerative, colitis, spread, throu. Pancolitis in its most general sense refers to inflammation of the entire colon This can be caused by a variety of things Pancolitis or universal colitis is frequently used in a more specific fashion to denote a very severe form of ulcerative colitis This form of ulcerative colitis is spread throughout the entire large intestine including the right colon the left colon the transverse colon descending colon and the rectum A diagnosis can be made using a number of techniques but the most accurate method is direct visualization via a colonoscopy 1 Symptoms are similar to those of ulcerative colitis but more severe and affect the entire large intestine Patients with ulcerative colitis generally exhibit symptoms including rectal bleeding as a result of ulcers pain in the abdominal region inflammation in varying degrees and diarrhea often containing blood Pancolitis patients exhibit these symptoms and may also experience fatigue fever and night sweats 2 3 Due to the loss of function in the large intestine patients may lose large amounts of weight from being unable to procure nutrients from food 4 In other cases the blood loss from ulcers can result in anemia which can be treated with iron supplements Additionally due to the chronic nature of most cases of pancolitis patients have a higher chance of developing colon cancer citation needed PancolitisThis condition affects the large intestine Pancolitis is a kind of inflammatory bowel disease IBD that affects the entire internal lining of the colon The precise causes of this inflammatory disorder are unclear although physicians currently believe that autoimmune diseases and genetic predispositions might play a role in its progress Genes that are known to put individuals at risk for Crohn s disease have been shown to also increase risk of other IBD including pancolitis 5 Furthermore an individual may also develop pancolitis if ulcerative colitis of only a small portion of the colon is left untreated or worsens 3 Current treatment of pancolitis is focused on forcing the disease into remission a state where the majority of the symptoms subside Ultimately the goal is to reach an improved quality of life reduction in need for medicine and minimization of the risk of cancer 3 6 Medication utilized in treatment includes anti inflammatory agents and corticosteroids to alleviate inflammation and immunomodulators which act to suppress the immune system Immunomodulators are used in severe cases of ulcerative colitis and often utilized to treat patients with pancolitis who have shown little improvement with anti inflammatories and corticosteroids 2 3 5 However in this case it can further expose the patient to other diseases due to the compromised immune system A final option of treatment is available in the form of surgery Generally this option is reserved for only the cases in which cancer development is highly suspected or major hemorrhaging from ulcers occurs In this case the entire colon and rectum are removed which both cures the pancolitis and prevents any chance of colon cancer Patients who undergo surgery either must have their stool collect in a reservoir made in place of the rectum or have the end of the small intestine attached to the anus In the latter case the diseased portion of the anus must be removed but the muscles are left intact allowing bowel movement to still take place 7 References edit Bennett A L Buckton S Lawrance I Leong R W Moore G Andrews J M 2015 12 01 Ulcerative colitis outpatient management development and evaluation of tools to support primary care practitioners Internal Medicine Journal 45 12 1254 1266 doi 10 1111 imj 12872 ISSN 1445 5994 PMID 26256445 S2CID 21182584 a b Hoy Sheridan M 2015 04 29 Budesonide MMX A Review of Its Use in Patients with Mild to Moderate Ulcerative Colitis Drugs 75 8 879 886 doi 10 1007 s40265 015 0396 8 ISSN 0012 6667 PMID 25920500 S2CID 20149154 a b c d Ulcerative Colitis Symptoms Diet Treatment amp Medication Retrieved 2016 06 27 Ulcerative colitis 2016 03 17 Retrieved 2016 06 27 a b Franke Andre Balschun Tobias Sina Christian Ellinghaus David Hasler Robert Mayr Gabriele Albrecht Mario Wittig Michael Buchert Eva 2010 Genome wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 IL17REL Nature Genetics 42 4 292 294 doi 10 1038 ng 553 PMID 20228798 S2CID 205356523 Rubin D T Ananthakrishnan A N Siegel C A Sauer B G Long M D 2019 Ulcerative Colitis in Adults American College of Gastroenterology The American Journal of Gastroenterology 114 3 384 413 doi 10 14309 ajg 0000000000000152 PMID 30840605 S2CID 73473272 Retrieved 2016 06 27 Vella M Masood M R amp Hendry W S 2007 Surgery for ulcerative colitis Surgeon Edinburgh University Press 5 6 356 362 External links editMedscape UC Patient UK UC Retrieved from https en wikipedia org w index php title Pancolitis amp oldid 1169981974, wikipedia, wiki, book, books, library,
