Plasmodium helical interspersed subtelomeric protein
December 18, 2023
The Plasmodium helical interspersed subtelomeric proteins (PHIST) or ring-infected erythrocyte surface antigens (RESA) are a family of protein domains found in the malaria-causing Plasmodium species. It was initially identified as a short four-helical conserved region in the single-domain export proteins,[1] but the identification of this part associated with a DnaJ domain in P. falciparum RESA (named after the ring stage of the parasite) has led to its reclassification as the RESA N-terminal domain. This domain has been classified into three subfamilies, PHISTa, PHISTb, and PHISTc.[2]
Also IPR006526. The structure is chain-swapped: each side of the blue line is a "solution" monomer.
The PHIST proteins are exported to the cytoplasm of the infected erythrocyte. The human malaria parasites P. falciparum and P. vivax have shown a lineage-specific expansion of proteins with this domain.[1] Of the two PHIST genes in the mouse parasite P. berghei, only one is required for infection.[3] The PHIST domain folds into three long helices (forming a bundle) and two smaller N-terminal helices, and is monomeric in solution. It binds PfEMP1 ATS C-terminus and plays a role in "knob" formation.[4]
The full RESA protein in P. falciparum also contains a few other domains, namely the DnaJ domain and the DnaJ-associated X domain. A part of the X-domain, RESA/P13830663-670, appears to bind and reinforce spectrin cytoskeleton so that each erythrocyte only hosts one parasite.[5]
P. falciparum isolate 3D7 encodes three RESA-family proteins, RESA-1 (P13830/Q8I0U6/PF3D7_0102200), RESA-2 (M91672.1/UPI0000084FE4/PF3D7_1149500), RESA-3 (Q8IHN1/PF3D7_1149200). RESA-2 is usually considered a transcribed pseudogene due to a premature stop codon. However, a missense mutation T1526G or T1526C in RESA-2 that removes this stop codon is commly found. It is associated with increased severity of disease.[6][7]
Notesedit
Referencesedit
^ abSargeant TJ, Marti M, Caler E, Carlton JM, Simpson K, Speed TP, Cowman AF (2006). "Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites". Genome Biology. 7 (2): R12. doi:10.1186/gb-2006-7-2-r12. PMC1431722. PMID 16507167.
^Oakley MS, Kumar S, Anantharaman V, Zheng H, Mahajan B, Haynes JD, et al. (April 2007). "Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites". Infection and Immunity. 75 (4): 2012–25. doi:10.1128/IAI.01236-06. PMC1865691. PMID 17283083.
^Moreira CK, Naissant B, Coppi A, Bennett BL, Aime E, Franke-Fayard B, et al. (29 March 2016). "The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites". PLOS ONE. 11 (3): e0152510. Bibcode:2016PLoSO..1152510M. doi:10.1371/journal.pone.0152510. PMC4811531. PMID 27022937.
^Oberli A, Slater LM, Cutts E, Brand F, Mundwiler-Pachlatko E, Rusch S, et al. (October 2014). "A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface". FASEB Journal. 28 (10): 4420–33. doi:10.1096/fj.14-256057. PMC4202109. PMID 24983468.
^Pei X, Guo X, Coppel R, Bhattacharjee S, Haldar K, Gratzer W, et al. (August 2007). "The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion". Blood. 110 (3): 1036–42. doi:10.1182/blood-2007-02-076919. PMC1924765. PMID 17468340.
^Badaut C, Guyonnet L, Milet J, Renard E, Durand R, Viwami F, et al. (July 2015). "Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria". Malaria Journal. 14: 278. doi:10.1186/s12936-015-0799-8. PMC4502540. PMID 26178656.
^Durand R, Migot-Nabias F, Andriantsoanirina V, Seringe E, Viwami F, Sagbo G, et al. (April 2012). "Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria". Malaria Journal. 11 (1): 128. doi:10.1186/1475-2875-11-128. PMC3422168. PMID 22533816.
December 18, 2023
plasmodium, helical, interspersed, subtelomeric, protein, phist, ring, infected, erythrocyte, surface, antigens, resa, family, protein, domains, found, malaria, causing, plasmodium, species, initially, identified, short, four, helical, conserved, region, singl. The Plasmodium helical interspersed subtelomeric proteins PHIST or ring infected erythrocyte surface antigens RESA are a family of protein domains found in the malaria causing Plasmodium species It was initially identified as a short four helical conserved region in the single domain export proteins 1 but the identification of this part associated with a DnaJ domain in P falciparum RESA named after the ring stage of the parasite has led to its reclassification as the RESA N terminal domain This domain has been classified into three subfamilies PHISTa PHISTb and PHISTc 2 Plasmodium RESA N terminalIdentifiersSymbolPRESANPfamPF09687InterProIPR019111CATH4jleAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryAlso IPR006526 The structure is chain swapped each side of the blue line is a solution monomer The PHIST proteins are exported to the cytoplasm of the infected erythrocyte The human malaria parasites P falciparum and P vivax have shown a lineage specific expansion of proteins with this domain 1 Of the two PHIST genes in the mouse parasite P berghei only one is required for infection 3 The PHIST domain folds into three long helices forming a bundle and two smaller N terminal helices and is monomeric in solution It binds PfEMP1 ATS C terminus and plays a role in knob formation 4 RESA editRing infected erythrocyte surface antigenIdentifiersOrganismPlasmodium falciparum FC27 Papua New GuineaSymbolRESAAlt symbolsPf155 RESA 1UniProtP13830Search forStructuresSwiss modelDomainsInterProThe full RESA protein in P falciparum also contains a few other domains namely the DnaJ domain and the DnaJ associated X domain A part of the X domain RESA P13830663 670 appears to bind and reinforce spectrin cytoskeleton so that each erythrocyte only hosts one parasite 5 P falciparum isolate 3D7 encodes three RESA family proteins RESA 1 P13830 wbr Q8I0U6 wbr PF3D7 0102200 RESA 2 M91672 1 wbr UPI0000084FE4 wbr PF3D7 1149500 RESA 3 Q8IHN1 wbr PF3D7 1149200 RESA 2 is usually considered a transcribed pseudogene due to a premature stop codon However a missense mutation T1526G or T1526C in RESA 2 that removes this stop codon is commly found It is associated with increased severity of disease 6 7 Notes editReferences edit a b Sargeant TJ Marti M Caler E Carlton JM Simpson K Speed TP Cowman AF 2006 Lineage specific expansion of proteins exported to erythrocytes in malaria parasites Genome Biology 7 2 R12 doi 10 1186 gb 2006 7 2 r12 PMC 1431722 PMID 16507167 Oakley MS Kumar S Anantharaman V Zheng H Mahajan B Haynes JD et al April 2007 Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites Infection and Immunity 75 4 2012 25 doi 10 1128 IAI 01236 06 PMC 1865691 PMID 17283083 Moreira CK Naissant B Coppi A Bennett BL Aime E Franke Fayard B et al 29 March 2016 The Plasmodium PHIST and RESA Like Protein Families of Human and Rodent Malaria Parasites PLOS ONE 11 3 e0152510 Bibcode 2016PLoSO 1152510M doi 10 1371 journal pone 0152510 PMC 4811531 PMID 27022937 Oberli A Slater LM Cutts E Brand F Mundwiler Pachlatko E Rusch S et al October 2014 A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface FASEB Journal 28 10 4420 33 doi 10 1096 fj 14 256057 PMC 4202109 PMID 24983468 Pei X Guo X Coppel R Bhattacharjee S Haldar K Gratzer W et al August 2007 The ring infected erythrocyte surface antigen RESA of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion Blood 110 3 1036 42 doi 10 1182 blood 2007 02 076919 PMC 1924765 PMID 17468340 Badaut C Guyonnet L Milet J Renard E Durand R Viwami F et al July 2015 Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria Malaria Journal 14 278 doi 10 1186 s12936 015 0799 8 PMC 4502540 PMID 26178656 Durand R Migot Nabias F Andriantsoanirina V Seringe E Viwami F Sagbo G et al April 2012 Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria Malaria Journal 11 1 128 doi 10 1186 1475 2875 11 128 PMC 3422168 PMID 22533816 Retrieved from https en wikipedia org w index php title Plasmodium helical interspersed subtelomeric protein amp oldid 1188169622, wikipedia, wiki, book, books, library,
