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Wikipedia

PGA5

August 27, 2023

Pepsinogen A is a protein that in humans is encoded by the PGA5 gene.[3]

PGA5
Identifiers
AliasesPGA5, Pg5, pepsinogen 5, group I (pepsinogen A), pepsinogen A5
External IDsOMIM: 169730 HomoloGene: 68135 GeneCards: PGA5
Orthologs
SpeciesHumanMouse
Entrez

5222

n/a

Ensembl

ENSG00000256713

n/a

UniProt

P0DJD9

n/a

RefSeq (mRNA)

NM_014224

n/a

RefSeq (protein)

NP_055039

n/a

Location (UCSC)Chr 11: 61.24 – 61.25 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000256713 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: PGA5 pepsinogen 5, group I (pepsinogen A)".

Further reading Edit

  • Ichinose M, Miki K, Wong RN, et al. (1991). "Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer". Jpn. J. Cancer Res. 82 (6): 686–92. doi:10.1111/j.1349-7006.1991.tb01904.x. PMC 5918501. PMID 1906854.
  • Ichihara Y, Sogawa K, Takahashi K (1986). "Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences". J. Biochem. 98 (2): 483–92. doi:10.1093/oxfordjournals.jbchem.a135303. PMID 2415509.
  • Athauda SB, Tanji M, Kageyama T, Takahashi K (1990). "A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins". J. Biochem. 106 (5): 920–7. doi:10.1093/oxfordjournals.jbchem.a122952. PMID 2515193.
  • Hengels KJ, Strohmeyer G (1990). "Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays". Zeitschrift für Gastroenterologie. 27 (8): 406–11. PMID 2609705.
  • Evers MP, Zelle B, Bebelman JP, et al. (1989). "Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family". Genomics. 4 (3): 232–9. doi:10.1016/0888-7543(89)90325-X. PMID 2714789.
  • ten Kate RW, Pals G, Donker AJ, et al. (1989). "Tubular handling of pepsinogen A and C in man: evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man". Nephron. 53 (3): 223–8. doi:10.1159/000185748. PMID 2797342.
  • ten Kate RW, Pals G, Eriksson AW, et al. (1989). "The renal metabolism of pepsinogen A and C in man". Clin. Nephrol. 31 (2): 103–6. PMID 2920466.
  • Evers MP, Zelle B, Peeper DS, et al. (1987). "Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide". Hum. Genet. 77 (2): 182–7. doi:10.1007/BF00272389. PMID 3115885. S2CID 24813698.
  • Pals G, Eriksson AW, Pronk JC, et al. (1989). "Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus". Clin. Genet. 34 (2): 90–7. doi:10.1111/j.1399-0004.1988.tb02842.x. PMID 3191614. S2CID 24053431.
  • Foltmann B (1989). "Activation of human pepsinogens". FEBS Lett. 241 (1–2): 69–72. doi:10.1016/0014-5793(88)81033-0. PMID 3197840. S2CID 29212503.
  • Westerveld BD, Pals G, Bosma A, et al. (1987). "Gastric proteases in Barrett's esophagus". Gastroenterology. 93 (4): 774–8. doi:10.1016/0016-5085(87)90439-2. PMID 3305135.
  • Nakai H, Byers MG, Shows TB, Taggart RT (1987). "Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization". Cytogenet. Cell Genet. 43 (3–4): 215–7. doi:10.1159/000132324. PMID 3467902.
  • Sogawa K, Fujii-Kuriyama Y, Mizukami Y, et al. (1983). "Primary structure of human pepsinogen gene". J. Biol. Chem. 258 (8): 5306–11. doi:10.1016/S0021-9258(18)32572-9. PMID 6300126.
  • Fujinaga M, Chernaia MM, Tarasova NI, et al. (1995). "Crystal structure of human pepsin and its complex with pepstatin". Protein Sci. 4 (5): 960–72. doi:10.1002/pro.5560040516. PMC 2143119. PMID 7663352.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Zwiers A, ten Dam MA, Crusius JB, et al. (1994). "The renal handling of pepsinogen A isozymogens in man". Clin. Nephrol. 41 (3): 153–8. PMID 8187358.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Plebani M, Basso D, Navaglia F, DiMario F (1998). "Helicobacter pylori genotypes influence serum pepsinogen C levels". Helicobacter. 2 (4): 172–5. doi:10.1111/j.1523-5378.1997.tb00082.x. PMID 9421118. S2CID 23419977.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
 

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

August 27, 2023
pga5, pepsinogen, protein, that, humans, encoded, gene, identifiersaliases, pepsinogen, group, pepsinogen, pepsinogen, a5external, idsomim, 169730, homologene, 68135, genecards, gene, location, human, chromosome, human, band11q12, 2start61, end61, expression, . Pepsinogen A is a protein that in humans is encoded by the PGA5 gene 3 PGA5IdentifiersAliasesPGA5 Pg5 pepsinogen 5 group I pepsinogen A pepsinogen A5External IDsOMIM 169730 HomoloGene 68135 GeneCards PGA5Gene location Human Chr Chromosome 11 human 1 Band11q12 2Start61 241 175 bp 1 End61 251 444 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inbody of stomachright uterine tubefundusright coronary arterycanal of the cervixleft uterine tubebody of pancreasright adrenal glandright lobe of liverspleenn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionhydrolase activity aspartic type endopeptidase activity peptidase activityCellular componentextracellular region extracellular exosome multivesicular body lumenBiological processdigestion protein catabolic process proteolysis autophagySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5222n aEnsemblENSG00000256713n aUniProtP0DJD9n aRefSeq mRNA NM 014224n aRefSeq protein NP 055039n aLocation UCSC Chr 11 61 24 61 25 Mbn aPubMed search 2 n aWikidataView Edit HumanReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000256713 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PGA5 pepsinogen 5 group I pepsinogen A Further reading EditIchinose M Miki K Wong RN et al 1991 Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer Jpn J Cancer Res 82 6 686 92 doi 10 1111 j 1349 7006 1991 tb01904 x PMC 5918501 PMID 1906854 Ichihara Y Sogawa K Takahashi K 1986 Isolation of human swine and rat prepepsinogens and calf preprochymosin and determination of the primary structures of their NH2 terminal signal sequences J Biochem 98 2 483 92 doi 10 1093 oxfordjournals jbchem a135303 PMID 2415509 Athauda SB Tanji M Kageyama T Takahashi K 1990 A comparative study on the NH2 terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins J Biochem 106 5 920 7 doi 10 1093 oxfordjournals jbchem a122952 PMID 2515193 Hengels KJ Strohmeyer G 1990 Pepsinogens A and C purification from human gastric mucosa and determination in serum by optimized radioimmunoassays Zeitschrift fur Gastroenterologie 27 8 406 11 PMID 2609705 Evers MP Zelle B Bebelman JP et al 1989 Nucleotide sequence comparison of five human pepsinogen A PGA genes evolution of the PGA multigene family Genomics 4 3 232 9 doi 10 1016 0888 7543 89 90325 X PMID 2714789 ten Kate RW Pals G Donker AJ et al 1989 Tubular handling of pepsinogen A and C in man evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man Nephron 53 3 223 8 doi 10 1159 000185748 PMID 2797342 ten Kate RW Pals G Eriksson AW et al 1989 The renal metabolism of pepsinogen A and C in man Clin Nephrol 31 2 103 6 PMID 2920466 Evers MP Zelle B Peeper DS et al 1987 Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu Lys mutation in the activation peptide Hum Genet 77 2 182 7 doi 10 1007 BF00272389 PMID 3115885 S2CID 24813698 Pals G Eriksson AW Pronk JC et al 1989 Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus Clin Genet 34 2 90 7 doi 10 1111 j 1399 0004 1988 tb02842 x PMID 3191614 S2CID 24053431 Foltmann B 1989 Activation of human pepsinogens FEBS Lett 241 1 2 69 72 doi 10 1016 0014 5793 88 81033 0 PMID 3197840 S2CID 29212503 Westerveld BD Pals G Bosma A et al 1987 Gastric proteases in Barrett s esophagus Gastroenterology 93 4 774 8 doi 10 1016 0016 5085 87 90439 2 PMID 3305135 Nakai H Byers MG Shows TB Taggart RT 1987 Assignment of the pepsinogen gene complex PGA to human chromosome region 11q13 by in situ hybridization Cytogenet Cell Genet 43 3 4 215 7 doi 10 1159 000132324 PMID 3467902 Sogawa K Fujii Kuriyama Y Mizukami Y et al 1983 Primary structure of human pepsinogen gene J Biol Chem 258 8 5306 11 doi 10 1016 S0021 9258 18 32572 9 PMID 6300126 Fujinaga M Chernaia MM Tarasova NI et al 1995 Crystal structure of human pepsin and its complex with pepstatin Protein Sci 4 5 960 72 doi 10 1002 pro 5560040516 PMC 2143119 PMID 7663352 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Zwiers A ten Dam MA Crusius JB et al 1994 The renal handling of pepsinogen A isozymogens in man Clin Nephrol 41 3 153 8 PMID 8187358 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Plebani M Basso D Navaglia F DiMario F 1998 Helicobacter pylori genotypes influence serum pepsinogen C levels Helicobacter 2 4 172 5 doi 10 1111 j 1523 5378 1997 tb00082 x PMID 9421118 S2CID 23419977 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PGA5 amp oldid 1170089023, wikipedia, wiki, book, books, library,

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