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Ottawa Hospital Research Institute

February 25, 2023

The Ottawa Hospital Research Institute (OHRI), formerly Ottawa Health Research Institute,[1] is a non-profit academic health research institute located in the city of Ottawa. It was formed in 2001 following the merger of three Ottawa hospitals. The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and affiliated with the University of Ottawa.

As of 2022, the Ottawa Hospital Research Institute houses approximately 2,200 scientists, clinician investigators, students, research fellows, and support staff.[2][3] It has five research programs: Cancer Therapeutics; Chronic Disease; Clinical Epidemiology; Regenerative Medicine; and Neurosciences.[4] Its researchers are studying more than a hundred different diseases, conditions and specialties with an overall focus on translating discoveries and knowledge into better health.[5]

Ronald G. Worton was the research institute's founding CEO and Scientific Director in 2001.[6] In 2007, Duncan Stewart, formerly Chief Cardiologist of St. Michael's Hospital in Toronto and Director of Cardiology of University of Toronto, took over as CEO and Scientific Director.[7][8]

Notable Discoveries and Accomplishments

  • Dr. Harold Atkins and Dr. Mark Freedman pioneered the use of autologous hematopoietic stem cell transplantation for the treatment of multiple sclerosis.[9]
  • Dr. Michael Rudnicki was the first to characterize adult skeletal muscle stem cells.[10]
  • Dr. Ian Stiell developed the Ottawa Ankle Rules.
  • Dr. David Moher led the development of the CONSORT reporting guidelines for clinical trials and the PRISMA reporting guidelines for systematic reviews and meta-analyses.
  • Dr. Doug Manuel developed ProjectBigLife, a life expectancy calculator that helps educate people about healthy lifestyle choices.
  • Dr. John Bell and his colleagues demonstrated for the first time that an intravenously-delivered viral therapy can selectively infect and spread within tumours in humans.[11]
  • Dr. Dean Fergusson and Dr. Paul Hebert discovered that aprotinin is associated with an increased risk of death compared to other drugs routinely used to prevent blood loss during heart surgery.[12]
  • Dr. Annette O'Connor pioneered the use of Patient Decision Aids.
  • Dr. Natasha Kekre is leading the first clinical trial of made-in-Canada CAR-T cells for the treatment of cancer.[1]

Notable Faculty and Alumni


References

  1. ^ Ottawa Hospital Research Institute (April 22, 2009). "Ottawa Health Research Institute changes name to Ottawa Hospital Research Institute". Retrieved June 5, 2014.
  2. ^ "Ottawa Hospital Research Institute". www.ohri.ca. Retrieved 2022-11-02.
  3. ^ . Ottawa Hospital Research Institute. Archived from the original on 2013-07-02.
  4. ^ "Research Programs". Ottawa Hospital Research Institute.
  5. ^ "Ottawa Hospital Research Institute". www.ohri.ca. Retrieved 2022-11-02.
  6. ^ "Dr. Ronald Worton, Founding CEO of the Ottawa Hospital Research Institute, to be inducted into the Canadian Medical Hall of Fame". Ottawa Hospital Research Institute. September 24, 2013.
  7. ^ "Dr. Duncan Stewart, science director at the Ottawa Hospital Research Institute, has been named to head up the Canadian Vascular Network". Ottawa Citizen. February 23, 2014. Archived from the original on June 9, 2014.
  8. ^ "Ottawa Health Research Institute holds Annual General Meeting and welcomes new CEO". Ottawa Hospital Research Institute. September 24, 2007.
  9. ^ Atkins, Harold L.; Bowman, Marjorie; Allan, David; Anstee, Grizel; Arnold, Douglas L.; Bar-Or, Amit; Bence-Bruckler, Isabelle; Birch, Paul; Bredeson, Christopher; Chen, Jacqueline; Fergusson, Dean; Halpenny, Mike; Hamelin, Linda; Huebsch, Lothar; Hutton, Brian (2016-08-06). "Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial". The Lancet. 388 (10044): 576–585. doi:10.1016/S0140-6736(16)30169-6. ISSN 0140-6736. PMID 27291994. S2CID 4530484.
  10. ^ Kuang, Shihuan; Kuroda, Kazuki; Le Grand, Fabien; Rudnicki, Michael A. (2007-06-01). "Asymmetric self-renewal and commitment of satellite stem cells in muscle". Cell. 129 (5): 999–1010. doi:10.1016/j.cell.2007.03.044. ISSN 0092-8674. PMC 2718740. PMID 17540178.
  11. ^ Breitbach, Caroline J.; Burke, James; Jonker, Derek; Stephenson, Joe; Haas, Andrew R.; Chow, Laura Q. M.; Nieva, Jorge; Hwang, Tae-Ho; Moon, Anne; Patt, Richard; Pelusio, Adina; Le Boeuf, Fabrice; Burns, Joe; Evgin, Laura; De Silva, Naomi (2011-08-31). "Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans". Nature. 477 (7362): 99–102. doi:10.1038/nature10358. ISSN 1476-4687. PMID 21886163. S2CID 4365604.
  12. ^ Fergusson, Dean A.; Hébert, Paul C.; Mazer, C. David; Fremes, Stephen; MacAdams, Charles; Murkin, John M.; Teoh, Kevin; Duke, Peter C.; Arellano, Ramiro; Blajchman, Morris A.; Bussières, Jean S.; Côté, Dany; Karski, Jacek; Martineau, Raymond; Robblee, James A. (2008-05-29). "A comparison of aprotinin and lysine analogues in high-risk cardiac surgery". The New England Journal of Medicine. 358 (22): 2319–2331. doi:10.1056/NEJMoa0802395. ISSN 1533-4406. PMID 18480196.

External links

  • Official Site

Coordinates: 45°23′35″N 75°43′26″W / 45.39307°N 75.72391°W / 45.39307; -75.72391

February 25, 2023
ottawa, hospital, research, institute, this, article, relies, excessively, references, primary, sources, please, improve, this, article, adding, secondary, tertiary, sources, find, sources, news, newspapers, books, scholar, jstor, june, 2014, learn, when, remo. This article relies excessively on references to primary sources Please improve this article by adding secondary or tertiary sources Find sources Ottawa Hospital Research Institute news newspapers books scholar JSTOR June 2014 Learn how and when to remove this template message The Ottawa Hospital Research Institute OHRI formerly Ottawa Health Research Institute 1 is a non profit academic health research institute located in the city of Ottawa It was formed in 2001 following the merger of three Ottawa hospitals The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and affiliated with the University of Ottawa As of 2022 the Ottawa Hospital Research Institute houses approximately 2 200 scientists clinician investigators students research fellows and support staff 2 3 It has five research programs Cancer Therapeutics Chronic Disease Clinical Epidemiology Regenerative Medicine and Neurosciences 4 Its researchers are studying more than a hundred different diseases conditions and specialties with an overall focus on translating discoveries and knowledge into better health 5 Ronald G Worton was the research institute s founding CEO and Scientific Director in 2001 6 In 2007 Duncan Stewart formerly Chief Cardiologist of St Michael s Hospital in Toronto and Director of Cardiology of University of Toronto took over as CEO and Scientific Director 7 8 Contents 1 Notable Discoveries and Accomplishments 2 Notable Faculty and Alumni 3 References 4 External linksNotable Discoveries and Accomplishments EditDr Harold Atkins and Dr Mark Freedman pioneered the use of autologous hematopoietic stem cell transplantation for the treatment of multiple sclerosis 9 Dr Michael Rudnicki was the first to characterize adult skeletal muscle stem cells 10 Dr Ian Stiell developed the Ottawa Ankle Rules Dr David Moher led the development of the CONSORT reporting guidelines for clinical trials and the PRISMA reporting guidelines for systematic reviews and meta analyses Dr Doug Manuel developed ProjectBigLife a life expectancy calculator that helps educate people about healthy lifestyle choices Dr John Bell and his colleagues demonstrated for the first time that an intravenously delivered viral therapy can selectively infect and spread within tumours in humans 11 Dr Dean Fergusson and Dr Paul Hebert discovered that aprotinin is associated with an increased risk of death compared to other drugs routinely used to prevent blood loss during heart surgery 12 Dr Annette O Connor pioneered the use of Patient Decision Aids Dr Natasha Kekre is leading the first clinical trial of made in Canada CAR T cells for the treatment of cancer 1 Notable Faculty and Alumni EditJohn Cameron Bell Dean Fergusson Ian Graham Jeremy Grimshaw Michael McBurney David Moher Annette O Connor Michael RudnickiReferences Edit Ottawa Hospital Research Institute April 22 2009 Ottawa Health Research Institute changes name to Ottawa Hospital Research Institute Retrieved June 5 2014 Ottawa Hospital Research Institute www ohri ca Retrieved 2022 11 02 Our People Ottawa Hospital Research Institute Archived from the original on 2013 07 02 Research Programs Ottawa Hospital Research Institute Ottawa Hospital Research Institute www ohri ca Retrieved 2022 11 02 Dr Ronald Worton Founding CEO of the Ottawa Hospital Research Institute to be inducted into the Canadian Medical Hall of Fame Ottawa Hospital Research Institute September 24 2013 Dr Duncan Stewart science director at the Ottawa Hospital Research Institute has been named to head up the Canadian Vascular Network Ottawa Citizen February 23 2014 Archived from the original on June 9 2014 Ottawa Health Research Institute holds Annual General Meeting and welcomes new CEO Ottawa Hospital Research Institute September 24 2007 Atkins Harold L Bowman Marjorie Allan David Anstee Grizel Arnold Douglas L Bar Or Amit Bence Bruckler Isabelle Birch Paul Bredeson Christopher Chen Jacqueline Fergusson Dean Halpenny Mike Hamelin Linda Huebsch Lothar Hutton Brian 2016 08 06 Immunoablation and autologous haemopoietic stem cell transplantation for aggressive multiple sclerosis a multicentre single group phase 2 trial The Lancet 388 10044 576 585 doi 10 1016 S0140 6736 16 30169 6 ISSN 0140 6736 PMID 27291994 S2CID 4530484 Kuang Shihuan Kuroda Kazuki Le Grand Fabien Rudnicki Michael A 2007 06 01 Asymmetric self renewal and commitment of satellite stem cells in muscle Cell 129 5 999 1010 doi 10 1016 j cell 2007 03 044 ISSN 0092 8674 PMC 2718740 PMID 17540178 Breitbach Caroline J Burke James Jonker Derek Stephenson Joe Haas Andrew R Chow Laura Q M Nieva Jorge Hwang Tae Ho Moon Anne Patt Richard Pelusio Adina Le Boeuf Fabrice Burns Joe Evgin Laura De Silva Naomi 2011 08 31 Intravenous delivery of a multi mechanistic cancer targeted oncolytic poxvirus in humans Nature 477 7362 99 102 doi 10 1038 nature10358 ISSN 1476 4687 PMID 21886163 S2CID 4365604 Fergusson Dean A Hebert Paul C Mazer C David Fremes Stephen MacAdams Charles Murkin John M Teoh Kevin Duke Peter C Arellano Ramiro Blajchman Morris A Bussieres Jean S Cote Dany Karski Jacek Martineau Raymond Robblee James A 2008 05 29 A comparison of aprotinin and lysine analogues in high risk cardiac surgery The New England Journal of Medicine 358 22 2319 2331 doi 10 1056 NEJMoa0802395 ISSN 1533 4406 PMID 18480196 External links EditOfficial Site Coordinates 45 23 35 N 75 43 26 W 45 39307 N 75 72391 W 45 39307 75 72391 Retrieved from https en wikipedia org w index php title Ottawa Hospital Research Institute amp oldid 1131309102, wikipedia, wiki, book, books, library,

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