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Wikipedia

Osteosclerosis

April 12, 2024

Not to be confused with Osteoporosis or Pachyostosis.

Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone. Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders.[1][2] It can manifest in localized or generalized osteosclerosis. Localized osteosclerosis can be caused by Legg–Calvé–Perthes disease, sickle-cell disease and osteoarthritis among others. Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary.[2][1]

Osteosclerosis
Sclerosis of the bones of the pelvis due to prostate cancer metastases
SpecialtyMedical genetics 

Types edit

Acquired osteosclerosis edit

Skeletal fluorosis

Hereditary osteosclerosis edit

  •  
    Sclerosis of the bones of the thoracic spine due to prostate cancer metastases (CT image)
  •  
    Sclerosis of the bones of the thoracic spine due to prostate cancer metastases (CT image)

Diagnosis edit

Osteosclerosis can be detected with a simple radiography. There are white portions of the bone which appear due to the increased number of bone trabeculae.[citation needed]

Animals edit

In the animal kingdom, there also exists a non-pathological form of osteosclerosis, resulting in unusually solid bone structure with little to no marrow. It is often seen in aquatic vertebrates, especially those living in shallow waters,[8] providing ballast as an adaptation for an aquatic lifestyle. It makes bones heavier, but also more fragile. In those animal groups, osteosclerosis often occurs together with bone thickening (pachyostosis). This joint occurrence is called pachyosteosclerosis.[9]

See also edit

References edit

  1. ^ a b EL-Sobky TA, Elsobky E, Sadek I, Elsayed SM, Khattab MF (2016). "A case of infantile osteopetrosis: The radioclinical features with literature update". Bone Rep. 4: 11–16. doi:10.1016/j.bonr.2015.11.002. PMC 4926827. PMID 28326337.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b c d e f Ihde LL, Forrester DM, Gottsegen CJ, Masih S, Patel DB, Vachon LA; et al. (2011). "Sclerosing bone dysplasias: Review and differentiation from other causes of osteosclerosis". RadioGraphics. 31 (7): 1865–82. doi:10.1148/rg.317115093. PMID 22084176.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Niederhauser, BD; Dingli, D; Kyle, RA; Ringler, MD (July 2014). "Imaging findings in 22 cases of Schnitzler syndrome: characteristic para-articular osteosclerosis, and the "hot knees" sign differential diagnosis". Skeletal Radiology. 43 (7): 905–15. doi:10.1007/s00256-014-1857-y. PMID 24652142. S2CID 1597002.
  4. ^ Orsolini, Giovanni; Viapiana, Ombretta; Rossini, Maurizio; Bonifacio, Massimiliano; Zanotti, Roberta (August 2018). "Bone Disease in Mastocytosis". Immunology and Allergy Clinics of North America. 38 (3): 443–454. doi:10.1016/j.iac.2018.04.013. PMID 30007462. S2CID 51628281.
  5. ^ Soubrier, M; Dubost, JJ; Jouanel, P; Tridon, A; Flori, B; Leguille, C; Ristori, JM; Bussière, JL (1994). "[Multiple complications of monoclonal IgM]". La Revue de Médecine Interne. 15 (7): 484–6. doi:10.1016/s0248-8663(05)81474-2. PMID 7938961.
  6. ^ Fiore CE, Riccobene S, Mangiafico R, Santoro F, Pennisi P (2005). "Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system" (PDF). Osteoporos Int. 16 (12): 2180–4. doi:10.1007/s00198-005-1858-8. PMID 15983730. S2CID 39008572.
  7. ^ EL-Sobky TA, El-Haddad A, Elsobky E, Elsayed SM, Sakr HM (2017). "Reversal of skeletal radiographic pathology in a case of malignant infantile osteopetrosis following hematopoietic stem cell transplantation". Egypt J Radiol Nucl Med. 48 (1): 237–43. doi:10.1016/j.ejrnm.2016.12.013.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Houssaye, A. (2009). "Pachyostosis" in aquatic amniotes: a review. Integrative Zoology 4(4): 325-340.
  9. ^ Crowell, Madelyn Galimore; Rahmat, Sulman; Koretsky, Irina (2020). "Correlation of Bone Density in Semi‐Aquatic and Aquatic Animals with Ecological and Dietary Specializations". The FASEB Journal. 34 (S1). Wiley: 1. doi:10.1096/fasebj.2020.34.s1.01860. ISSN 0892-6638. S2CID 218789355.

External links edit

April 12, 2024
osteosclerosis, confused, with, osteoporosis, pachyostosis, disorder, that, characterized, abnormal, hardening, bone, elevation, bone, density, predominantly, affect, medullary, portion, cortex, bone, plain, radiographs, valuable, tool, detecting, classifying,. Not to be confused with Osteoporosis or Pachyostosis Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density It may predominantly affect the medullary portion and or cortex of bone Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders 1 2 It can manifest in localized or generalized osteosclerosis Localized osteosclerosis can be caused by Legg Calve Perthes disease sickle cell disease and osteoarthritis among others Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary 2 1 OsteosclerosisSclerosis of the bones of the pelvis due to prostate cancer metastasesSpecialtyMedical genetics Contents 1 Types 1 1 Acquired osteosclerosis 1 2 Hereditary osteosclerosis 2 Diagnosis 3 Animals 4 See also 5 References 6 External linksTypes editAcquired osteosclerosis edit Osteogenic bone metastasis caused by carcinoma of prostate and breast Paget s disease of bone Myelofibrosis primary disorder or secondary to intoxication or malignancy Osteosclerosing types of chronic osteomyelitis Hypervitaminosis D hyperparathyroidism Schnitzler syndrome 3 Mastocytosis 4 Skeletal fluorosis Monoclonal IgM Kappa cryoglobulinemia 5 Hepatitis C 6 Hereditary osteosclerosis edit Malignant infantile osteopetrosis 7 Neuropathic infantile osteopetrosis Infantile osteopetrosis with renal tubular acidosis Infantile osteopetrosis with immunodeficiency IO with leukocyte adhesion deficiency syndrome LAD III Intermediate osteopetrosis Autosomal dominant osteopetrosis Albers Schonberg Pyknodysostosis osteopetrosis acro osteolytica 2 Osteopoikilosis Buschke Ollendorff syndrome 2 Osteopathia striata with cranial sclerosis 2 Mixed sclerosing bone dysplasia Progressive diaphyseal dysplasia Camurati Engelmann disease 2 SOST related sclerosing bone dysplasias nbsp Sclerosis of the bones of the thoracic spine due to prostate cancer metastases CT image nbsp Sclerosis of the bones of the thoracic spine due to prostate cancer metastases CT image Diagnosis editOsteosclerosis can be detected with a simple radiography There are white portions of the bone which appear due to the increased number of bone trabeculae citation needed Animals editIn the animal kingdom there also exists a non pathological form of osteosclerosis resulting in unusually solid bone structure with little to no marrow It is often seen in aquatic vertebrates especially those living in shallow waters 8 providing ballast as an adaptation for an aquatic lifestyle It makes bones heavier but also more fragile In those animal groups osteosclerosis often occurs together with bone thickening pachyostosis This joint occurrence is called pachyosteosclerosis 9 See also editAxial osteomalacia Pachyostosis Pachyosteosclerosis Heinrich Albers SchonbergReferences edit a b EL Sobky TA Elsobky E Sadek I Elsayed SM Khattab MF 2016 A case of infantile osteopetrosis The radioclinical features with literature update Bone Rep 4 11 16 doi 10 1016 j bonr 2015 11 002 PMC 4926827 PMID 28326337 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link a b c d e f Ihde LL Forrester DM Gottsegen CJ Masih S Patel DB Vachon LA et al 2011 Sclerosing bone dysplasias Review and differentiation from other causes of osteosclerosis RadioGraphics 31 7 1865 82 doi 10 1148 rg 317115093 PMID 22084176 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Niederhauser BD Dingli D Kyle RA Ringler MD July 2014 Imaging findings in 22 cases of Schnitzler syndrome characteristic para articular osteosclerosis and the hot knees sign differential diagnosis Skeletal Radiology 43 7 905 15 doi 10 1007 s00256 014 1857 y PMID 24652142 S2CID 1597002 Orsolini Giovanni Viapiana Ombretta Rossini Maurizio Bonifacio Massimiliano Zanotti Roberta August 2018 Bone Disease in Mastocytosis Immunology and Allergy Clinics of North America 38 3 443 454 doi 10 1016 j iac 2018 04 013 PMID 30007462 S2CID 51628281 Soubrier M Dubost JJ Jouanel P Tridon A Flori B Leguille C Ristori JM Bussiere JL 1994 Multiple complications of monoclonal IgM La Revue de Medecine Interne 15 7 484 6 doi 10 1016 s0248 8663 05 81474 2 PMID 7938961 Fiore CE Riccobene S Mangiafico R Santoro F Pennisi P 2005 Hepatitis C associated osteosclerosis HCAO report of a new case with involvement of the OPG RANKL system PDF Osteoporos Int 16 12 2180 4 doi 10 1007 s00198 005 1858 8 PMID 15983730 S2CID 39008572 EL Sobky TA El Haddad A Elsobky E Elsayed SM Sakr HM 2017 Reversal of skeletal radiographic pathology in a case of malignant infantile osteopetrosis following hematopoietic stem cell transplantation Egypt J Radiol Nucl Med 48 1 237 43 doi 10 1016 j ejrnm 2016 12 013 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Houssaye A 2009 Pachyostosis in aquatic amniotes a review Integrative Zoology 4 4 325 340 Crowell Madelyn Galimore Rahmat Sulman Koretsky Irina 2020 Correlation of Bone Density in Semi Aquatic and Aquatic Animals with Ecological and Dietary Specializations The FASEB Journal 34 S1 Wiley 1 doi 10 1096 fasebj 2020 34 s1 01860 ISSN 0892 6638 S2CID 218789355 External links edit Retrieved from https en wikipedia org w index php title Osteosclerosis amp oldid 1187661239, wikipedia, wiki, book, books, library,

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